CAJ | 학술논문

2009年中国12家教学医院革兰阳性球菌耐药性研究
2009년중국12가교학의원혁란양성구균내약성연구
An antimicrobial resistance surveillance of gram-positive cocci isolated from 12 teaching hospitals in China in 2009

万方数据

中华内科杂志中華內科雜誌 중화내과잡지
CHINESE JOURNAL OF INTERNAL MEDICINE
2010年 9期 735-740 ,共6页

孙宏莉%王辉%陈民钧%刘颖梅%胡志东%廖康%褚云卓%雷金娥%张兵%俞云松%胡必杰%孙自镛%张正%何启勇

손굉리%왕휘%진민균%류영매%호지동%료강%저운탁%뢰금아%장병%유운송%호필걸%손자용%장정%하계용

抗药性,细菌%抗菌药%革兰阳性球菌抗藥性,細菌%抗菌藥%革蘭暘性毬菌
항약성,세균%항균약%혁란양성구균
Drug resistance,bacterial%Anti-bacterial agents%Gram-positive cocci

目的调查2009年我国革兰阳性球菌临床分离株的耐药性.方法收集2009年6-12月9个城市12家教学医院临床分离的1169株非重复革兰阳性球菌.采用琼脂稀释法测定抗菌药物的最低抑菌浓度(MIC)值.结果金黄色葡萄球菌和凝固酶阴性葡萄球菌中耐苯唑西林菌株分别占45.3%(211/466)和89.5%(214/239);不同标本苯唑西林耐药金黄色葡萄球菌(MRSA)分离率为33.3%～68.1%.未发现对替考拉宁、万古霉素和利奈唑胺耐药的葡萄球菌.5.5%(7/128)的屎肠球菌对万古霉素耐药,未发现万古霉素耐药的粪肠球菌;粪肠球菌和屎肠球菌对利奈唑胺的敏感率约为99.1%(108/109).肺炎链球菌中青霉素中介株(P1SP)分离率为21.6%(48/222),仅发现1株青霉素耐药株(PRSP),占0.5%(1/222);未发现对替考拉宁、万古霉素和利奈唑胺耐药的肺炎链球菌.结论葡萄球菌中苯唑西林耐药菌株仍有较高的分离率,不同标本类型MRSA的分离率有所不同.替考拉宁、万古霉素和利奈唑胺对葡萄球菌、粪肠球菌、屎肠球菌和肺炎链球菌具有很好的抗菌活性.
목적 조사2009년아국혁란양성구균림상분리주적내약성.방법 수집2009년6-12월9개성시12가교학의원림상분리적1169주비중복혁란양성구균.채용경지희석법측정항균약물적최저억균농도(MIC)치.결과 금황색포도구균화응고매음성포도구균중내분서서림균주분별점45.3%(211/466)화89.5%(214/239);불동표본분서서림내약금황색포도구균(MRSA)분리솔위33.3%～68.1%.미발현대체고랍저、만고매소화리내서알내약적포도구균.5.5%(7/128)적시장구균대만고매소내약,미발현만고매소내약적분장구균;분장구균화시장구균대리내서알적민감솔약위99.1%(108/109).폐염련구균중청매소중개주(P1SP)분리솔위21.6%(48/222),부발현1주청매소내약주(PRSP),점0.5%(1/222);미발현대체고랍저、만고매소화리내서알내약적폐염련구균.결론 포도구균중분서서림내약균주잉유교고적분리솔,불동표본류형MRSA적분리솔유소불동.체고랍저、만고매소화리내서알대포도구균、분장구균、시장구균화폐염련구균구유흔호적항균활성.
Objective To investigate antimicrobial resistance among gram-positive cocci in China in 2009. Methods From June to December 2009, 1169 consecutive and non-repetitive gram-positive cocci were collected from 12 teaching hospitals at 9 cities. The minimal inhibitory concentration (MIC) of antibacterial agents was determined by agar dilution method. Results The prevalences of methicillinresistant Staphylococcus aureus (MRSA) and methicillin-resistant coagulase-negative Staphylococci (MRCoNS) were 45.3% (211/466) and 89. 5% (214/239), respectively. The isolation rate of MRSA was 33. 3%-68. 1% from different samples. All Staphylococci isolates were susceptible to vacomycin, teicoplanin and linezolid. Five point five percent (7/128) E. faecium strains were resistant to vacomycin. All E.faecalis strains were susceptible to vacomycin. About 99. 1% (108/109) of E. faecalis and E. faecium were susceptible to linezoild. The prevalence of penicillin-intermediate Streptococcus pneumoniae (PISP) was 21.6% (48/222). Only 1 (0. 5%, 1/222) Streptococcus pneumoniae strain was resistant to penicillin.Teicoplanin, vancomycin, linezolid and tigecycline were the most active agents against Streptococcus pneumoniae (susceptible rate 100% ). Conclusions The high prevalence of methicillin-resistance is among Staphylococcus strains. Different samples show a different MRSA prevalence. Teicoplanin, vancomycin and linezolid show very high activity to Staphylococci,E. faecalis, E. faecium and Streptococcus pneumoniae.