CAJ | 학술논문

目的通过液压脑损伤大鼠行为学和脑电图的研究以探讨其在外伤后癫痫中的研究价值.方法建立液压脑损伤动物模型并进行为期3个月大鼠行为学和脑电图的观察、记录.结果液压脑损伤后50只大鼠死亡19只,存活的31只中有11只出现癫痫.癫痫的发作形式主要表现为面肌痉挛、点头样运动,其次为四肢抽搐、翻转跳起等.液压脑损伤后第2个月为癫痫发生的高峰期.癫痫发作时同期脑电图可见癫痫样放电.液压脑损伤后部分非癫痫大鼠脑电图表现为1～5导联波幅增高、频率增快.结论液压脑损伤后癫痫动物模型与临床外伤后癫痫相似,与其他外伤后癫痫动物模型相比,更具有研究价值.
목적 통과액압뇌손상대서행위학화뇌전도적연구이탐토기재외상후전간중적연구개치.방법 건립액압뇌손상동물모형병진행위기3개월대서행위학화뇌전도적관찰、기록.결과 액압뇌손상후50지대서사망19지,존활적31지중유11지출현전간.전간적발작형식주요표현위면기경련、점두양운동,기차위사지추휵、번전도기등.액압뇌손상후제2개월위전간발생적고봉기.전간발작시동기뇌전도가견전간양방전.액압뇌손상후부분비전간대서뇌전도표현위1～5도련파폭증고、빈솔증쾌.결론 액압뇌손상후전간동물모형여림상외상후전간상사,여기타외상후전간동물모형상비,경구유연구개치.
Objective To investigate the electroencephalogram and ethology in the rat with fluid percussion brain injury and approach its research value in the post traumatic epilepsy. Methods The change of ethology and electroencephalogram of rat in the three months after fluid percussion brain injury were observed and recorded. Results Among the survival 31 rats, there were 11 rats that appeared epilepsy. Epileptic seizure manifestation principally appeared as facial spasm, nod motion, and next limbs convulsion and turnover upspring, et al. The highest epileptic incidence rate appeared in 2 months after lateral fluid percussion brain injury. There were obvious epileptic discharges on the electroencephalogram of epileptic rats and higher wave amplitude and quicker frequency on the lead of 1～5 on the electroencephalogram of some no epileptic rats. Conclusions Post traumatic epilepsy after lateral fluid percussion brain injury in rat is similar with clinical post traumatic epilepsy. It has more research value than the other pest traumatic epileptic animal model.