中华整形外科杂志
中華整形外科雜誌
중화정형외과잡지
CHINESE JOURNAL OF PLASTIC SURGERY
2011年
5期
359-361
,共3页
赵忠芳%吕仁荣%霍然%傅洪滨%徐广琪%马少林
趙忠芳%呂仁榮%霍然%傅洪濱%徐廣琪%馬少林
조충방%려인영%곽연%부홍빈%서엄기%마소림
婴幼儿血管瘤%普萘洛尔%血管内皮生长因子%基质金属蛋白酶-9
嬰幼兒血管瘤%普萘洛爾%血管內皮生長因子%基質金屬蛋白酶-9
영유인혈관류%보내락이%혈관내피생장인자%기질금속단백매-9
Infantile hemangioma%Propranolol%Vascular endothelial growth factor%Matrix metalloproteinases-9
目的 研究普萘洛尔口服治疗增生期血管瘤，及对血清中血管内皮生长因子（vascular endothelial growth factor，VEGF）、基质金属蛋白酶-9(matrix metalloproteinase-9，MMP-9)水平的影响。方法 采用ELISA法检测患者服药4、8周后血清VEGF、MMP-9水平，并分析其与预后的关系。结果 治疗前血清VEGF水平最高，而服药后4周(255.7±130.4)和服药后8周(224.2±120.6)VEGF水平呈逐渐下降趋势，治疗后8周VEGF水平显著低于治疗前(P＜0.05)。MMP-9的表达变化与VEGF一致，并与VEGF呈正相关。结论 普萘洛尔可以通过降低患者血清VEGF和MMP-9水平，从而治疗增生期血管瘤。
目的 研究普萘洛爾口服治療增生期血管瘤，及對血清中血管內皮生長因子（vascular endothelial growth factor，VEGF）、基質金屬蛋白酶-9(matrix metalloproteinase-9，MMP-9)水平的影響。方法 採用ELISA法檢測患者服藥4、8週後血清VEGF、MMP-9水平，併分析其與預後的關繫。結果 治療前血清VEGF水平最高，而服藥後4週(255.7±130.4)和服藥後8週(224.2±120.6)VEGF水平呈逐漸下降趨勢，治療後8週VEGF水平顯著低于治療前(P＜0.05)。MMP-9的錶達變化與VEGF一緻，併與VEGF呈正相關。結論 普萘洛爾可以通過降低患者血清VEGF和MMP-9水平，從而治療增生期血管瘤。
목적 연구보내락이구복치료증생기혈관류，급대혈청중혈관내피생장인자（vascular endothelial growth factor，VEGF）、기질금속단백매-9(matrix metalloproteinase-9，MMP-9)수평적영향。방법 채용ELISA법검측환자복약4、8주후혈청VEGF、MMP-9수평，병분석기여예후적관계。결과 치료전혈청VEGF수평최고，이복약후4주(255.7±130.4)화복약후8주(224.2±120.6)VEGF수평정축점하강추세，치료후8주VEGF수평현저저우치료전(P＜0.05)。MMP-9적표체변화여VEGF일치，병여VEGF정정상관。결론 보내락이가이통과강저환자혈청VEGF화MMP-9수평，종이치료증생기혈관류。
Objective To study the level of serum vascular endothelial growth factor, matrix metalloproteinases-9 in the proliferative hemangioma before and after propranolol treatment. Methods The serum VEGF, MMP-9 was detected with ELISA assay before treatment and after 4 weeks and 8 weeks of propranolol treatment. The relationship between the serum VEGF, MMP-9 and the prognosis was analyzed. Results The serum VEGF(295.4 ± 158.1 ) pg/ml was high before treatment, then decreased after 4 weeks and 8 weeks of treatment (255.7 ± 130.4) pg/ml, (224.2 ± 120.6) pg/ml. The serum VEGF was significantly lower after 8 weeks of treatment( P ＜ 0.05 ). The serum MMP-9 was also decreased after treatment, showing a positive relationship with VEGF. Conclusions Propranolol can treat the proliferative hemangioma through decreasing the serum VEGF and MMP-9.
