中华结核和呼吸杂志
中華結覈和呼吸雜誌
중화결핵화호흡잡지
Chinese Journal of Tuberculosis and Respiratory Diseases
2011年
1期
13-16
,共4页
慈书平%高义%张希龙%茅建华%赵宁志%倪竞全%沈翔%丁敏%徐新献
慈書平%高義%張希龍%茅建華%趙寧誌%倪競全%瀋翔%丁敏%徐新獻
자서평%고의%장희룡%모건화%조저지%예경전%침상%정민%서신헌
睡眠呼吸暂停综合征%脑血管病%流行病学调查%随访
睡眠呼吸暫停綜閤徵%腦血管病%流行病學調查%隨訪
수면호흡잠정종합정%뇌혈관병%류행병학조사%수방
Sleep apnea syndrome%Cerebrovascular disease%Epidemiological survey%Follow-up
目的 调查随访阻塞性睡眠呼吸暂停综合征(OSAS)与脑血管病的关系.方法 对1989年11月至2009年11月南京军区所属3市及地区军队和地方离退休干部休养所进行体检的人群进行随访调查,随访期间每年进行1次体检,检查血压、血脂、血糖、心电图及X线胸片等,发现存在脑血管病表现时行头颅CT检查,以发生脑血管病为随访终点,随访时间为20年.结果 共纳入患者1868例,年龄53～82岁,平均(63±6)岁,其中男956例,平均(65±7)岁,女912例,平均(60±6)岁.其中确诊OSAS者598例(32.0%),纳入OSAS组,其中男496例(82.9%),女102例(17.1%);其余为对照组.随访终点比较结果显示,OSAS组白天嗜睡、头痛、记忆力减退、痴呆及语言障碍等发生率明显高于对照组(P＜0.05).OSAS组276例(46.2%)发生脑血管病,对照组发生150例(11.8%)(P＜0.01).随访期间死亡患者817例,其中OSAS组396/598例(66.2%),对照组421/1270例(33.1%,P＜0.01).随访结束时OSAS组脑血管病患病率为276/598例(46.2%),对照组170/1270例(13.4%,P＜0.01).结论 OSAS患者发生脑血管病可能性较一般人群高,考虑OSAS与发生脑血管病存在相关性,提示OSAS可能是脑血管病的独立危险因素.
目的 調查隨訪阻塞性睡眠呼吸暫停綜閤徵(OSAS)與腦血管病的關繫.方法 對1989年11月至2009年11月南京軍區所屬3市及地區軍隊和地方離退休榦部休養所進行體檢的人群進行隨訪調查,隨訪期間每年進行1次體檢,檢查血壓、血脂、血糖、心電圖及X線胸片等,髮現存在腦血管病錶現時行頭顱CT檢查,以髮生腦血管病為隨訪終點,隨訪時間為20年.結果 共納入患者1868例,年齡53～82歲,平均(63±6)歲,其中男956例,平均(65±7)歲,女912例,平均(60±6)歲.其中確診OSAS者598例(32.0%),納入OSAS組,其中男496例(82.9%),女102例(17.1%);其餘為對照組.隨訪終點比較結果顯示,OSAS組白天嗜睡、頭痛、記憶力減退、癡呆及語言障礙等髮生率明顯高于對照組(P＜0.05).OSAS組276例(46.2%)髮生腦血管病,對照組髮生150例(11.8%)(P＜0.01).隨訪期間死亡患者817例,其中OSAS組396/598例(66.2%),對照組421/1270例(33.1%,P＜0.01).隨訪結束時OSAS組腦血管病患病率為276/598例(46.2%),對照組170/1270例(13.4%,P＜0.01).結論 OSAS患者髮生腦血管病可能性較一般人群高,攷慮OSAS與髮生腦血管病存在相關性,提示OSAS可能是腦血管病的獨立危險因素.
목적 조사수방조새성수면호흡잠정종합정(OSAS)여뇌혈관병적관계.방법 대1989년11월지2009년11월남경군구소속3시급지구군대화지방리퇴휴간부휴양소진행체검적인군진행수방조사,수방기간매년진행1차체검,검사혈압、혈지、혈당、심전도급X선흉편등,발현존재뇌혈관병표현시행두로CT검사,이발생뇌혈관병위수방종점,수방시간위20년.결과 공납입환자1868례,년령53～82세,평균(63±6)세,기중남956례,평균(65±7)세,녀912례,평균(60±6)세.기중학진OSAS자598례(32.0%),납입OSAS조,기중남496례(82.9%),녀102례(17.1%);기여위대조조.수방종점비교결과현시,OSAS조백천기수、두통、기억력감퇴、치태급어언장애등발생솔명현고우대조조(P＜0.05).OSAS조276례(46.2%)발생뇌혈관병,대조조발생150례(11.8%)(P＜0.01).수방기간사망환자817례,기중OSAS조396/598례(66.2%),대조조421/1270례(33.1%,P＜0.01).수방결속시OSAS조뇌혈관병환병솔위276/598례(46.2%),대조조170/1270례(13.4%,P＜0.01).결론 OSAS환자발생뇌혈관병가능성교일반인군고,고필OSAS여발생뇌혈관병존재상관성,제시OSAS가능시뇌혈관병적독립위험인소.
Objective To explore the correlation between obstructive sleep apnea syndrome (OSAS) and cerebrovascular disease(CVD). Methods A cohort of 1868 people was screened for OSAS,and followed from November 1989 to November 2009. Annual medical examinations including blood pressure,blood fat, serum glucose, electrocardiogram and chest x-ray were performed. Computer tomography was carried out when CVD, the endpoint of the study, was manifested. Results Among the 1868 elderly people, 598 ( 32.0% ) were confirmed to have OSAS, including 496 ( 82.9% ) males and 102 ( 17. 1% )females. Compared with the non-OSAS group, patients with OSAS had more symptoms including daytime somnolence, headache, decreased ability of memory, aphronesia and allolalia( P ＜ 0. 05 ). CVD occurred in 276(46. 2% )patients of the OSAS group, but in 150( 11.8% , P ＜ 0. 01 )subjects of the non-OSAS group.During the 20-year follow-up, 817 people died, 66. 2% (396/598) in the OSAS group, but 33. 1% (421/1270) in the non-OSAS group ( P ＜0. 01 ). Conclusion Patients with OSAS are more likely to suffer from CVD. OSAS may be an independent risk factor for CVD.
