中华内分泌代谢杂志
中華內分泌代謝雜誌
중화내분비대사잡지
CHINESE JOURNAL OF ENDOCRINOLOGY AND METABOLISM
2012年
3期
237-238
,共2页
周海成%赵娟%杜建玲%邢倩%姚俊洁%刘丹%门莉莉
週海成%趙娟%杜建玲%邢倩%姚俊潔%劉丹%門莉莉
주해성%조연%두건령%형천%요준길%류단%문리리
梓醇%糖尿病肾病%胰岛素样生长因子I%蛋白激酶B
梓醇%糖尿病腎病%胰島素樣生長因子I%蛋白激酶B
재순%당뇨병신병%이도소양생장인자I%단백격매B
Catalpol%Diabetic nephropathy%Insulin-like growth factor - I%Protein kinase B
探讨梓醇对糖尿病大鼠肾脏是否具有保护作用及其可能机制.RT-PCR、免疫组化和Western印迹法检测糖尿病大鼠肾脏组织中胰岛素样生长因子I和蛋白激酶B表达,结果发现两者mRNA及蛋白表达均上调,梓醇可下调其表达并减轻肾脏损伤.
探討梓醇對糖尿病大鼠腎髒是否具有保護作用及其可能機製.RT-PCR、免疫組化和Western印跡法檢測糖尿病大鼠腎髒組織中胰島素樣生長因子I和蛋白激酶B錶達,結果髮現兩者mRNA及蛋白錶達均上調,梓醇可下調其錶達併減輕腎髒損傷.
탐토재순대당뇨병대서신장시부구유보호작용급기가능궤제.RT-PCR、면역조화화Western인적법검측당뇨병대서신장조직중이도소양생장인자I화단백격매B표체,결과발현량자mRNA급단백표체균상조,재순가하조기표체병감경신장손상.
This study was designed to explone whether catalpol exerts a protective effects on kidney of diabetic rats and its possible mechanism.Insulin-like growth factor- I ( IGF- I ) and protein kinase B (PKB/Akt)mRNA and protein expression in kidney of diabetic rats were up-regulated as results of assessments by RT-PCR,immunohistochemistry and Western blot.Catalpol could partially reduce IGF- Ⅰ and Akt expressions in kidney of diabetic rats,and thus alleviate the damage of kidney.
