CAJ | 학술논문

目的探讨北京地区已婚妇女生殖道高危型人乳头状瘤病毒(HR-HPV)感染与宫颈上皮内瘤变(CrN)的现患状况及其相关性.方法于2007年3月至2008年9月采用多阶段整群随机抽样的方法,在北京地区抽取12个区县137个社区25～54岁已婚妇女6185名,进行妇科体检、宫颈HR-HPV及细胞学检测,并进行问卷调查.对出现不典型鳞状上皮细胞及以上细胞学异常改变的妇女进行宫颈病理学检查.应用EpiData 3.0软件双次录入、审核数据后,使用SPSS 15.0软件进行统计分析.结果 (1)北京地区25～54岁已婚妇女生殖道HR-HPV感染率为9.9%,宫颈病变患病率为6.0%;(2)HR-HPV感染及宫颈病变患病高峰年龄均为30～34岁组;(3)HR-HPV感染者的宫颈细胞学异常率(40.3%)、宫颈病变患病率(30.4%)均明显高于未感染者;(4)多元logistic同归分析显示,与正常人群相比,HR-HPV感染对宫颈上皮内低度病变(CIN Ⅰ)组和高度病变及癌症(≥CIN Ⅱ)组的OR值分别为8.385和97.416,归因危险度百分比分别为88.1%和99.0%.结论 HR-HPV感染为宫颈病变的主要因素;30～34岁的已婚妇女是生殖道HR-HPV感染和宫颈病变的高发人群.
목적 탐토북경지구이혼부녀생식도고위형인유두상류병독(HR-HPV)감염여궁경상피내류변(CrN)적현환상황급기상관성.방법 우2007년3월지2008년9월채용다계단정군수궤추양적방법,재북경지구추취12개구현137개사구25～54세이혼부녀6185명,진행부과체검、궁경HR-HPV급세포학검측,병진행문권조사.대출현불전형린상상피세포급이상세포학이상개변적부녀진행궁경병이학검사.응용EpiData 3.0연건쌍차록입、심핵수거후,사용SPSS 15.0연건진행통계분석.결과 (1)북경지구25～54세이혼부녀생식도HR-HPV감염솔위9.9%,궁경병변환병솔위6.0%;(2)HR-HPV감염급궁경병변환병고봉년령균위30～34세조;(3)HR-HPV감염자적궁경세포학이상솔(40.3%)、궁경병변환병솔(30.4%)균명현고우미감염자;(4)다원logistic동귀분석현시,여정상인군상비,HR-HPV감염대궁경상피내저도병변(CIN Ⅰ)조화고도병변급암증(≥CIN Ⅱ)조적OR치분별위8.385화97.416,귀인위험도백분비분별위88.1%화99.0%.결론 HR-HPV감염위궁경병변적주요인소;30～34세적이혼부녀시생식도HR-HPV감염화궁경병변적고발인군.
Objective To investigate the prevalence and relationship between high risk human papillomavirus(HR-HPV)and cervical intraepithelial neoplasia(CIN)in married women from Beijing.Methods From March 2007 to September 2008,a total of 6185 married women were sampled,covering 137 communities in 12 districts.The samples were screened by high-risk HPV DNA test(HC2)and cytological test.For those participants with cytological test results≥ASCUS,pathological tests were performed.An interview was also carried out with the same questionnaire.Results from the tests were inputted into the database twice using EpiData 3.0,reviewed,analyzed,using SPSS 15.0.Results(1)The prevalence rates of HR-HPV and CIN were 9.9% and 6.0%,respectively for the age group 25 to 54.(2)The peak age groups for HR-HPV and CIN prevalence rates were 30 to 34 years old.(3)The prevalence rates of positive cytology(40.3%)and CIN (30.4%)in HR-HPV positive female population were significantly higher than that in HR-HPV negative group.(4)Data from unconditional logistic regression analysis showed that,when comparing with the normal subjects,the risk odds ratios of HR-HPV with low grade CIN and cervical cancer/high grade CIN were 8.385 and 97.416 and the attributable risk proportions with these groups were 88.1% and 99.0%,respectively.Conclusion HR-HPV infection seemed to be the main risk factor for CIN.Married women,from age group 30-34,were under the high risk group in both HR-HPV infection and CIN incidence.