中华心血管病杂志
中華心血管病雜誌
중화심혈관병잡지
Chinese Journal of Cardiology
2010年
11期
1038-1044
,共7页
刘品明%Shailendrasing Dosieah%郑海生%黄至斌%林永青%王景峰
劉品明%Shailendrasing Dosieah%鄭海生%黃至斌%林永青%王景峰
류품명%Shailendrasing Dosieah%정해생%황지빈%림영청%왕경봉
饮酒%冠状动脉疾病%死亡率%Meta分析
飲酒%冠狀動脈疾病%死亡率%Meta分析
음주%관상동맥질병%사망솔%Meta분석
Alcohol drinking%Coronary disease%Mortality%Meta-analysis
目的 探讨东亚男性饮酒对冠心病发病率、病死率和全因死亡率的影响.方法 检索Pubmed等数据库,纳入中国、日本、韩国符合入选条件的前瞻性队列研究.记录研究来源国家,例数,性别,年龄,随访期限,饮酒量,与饮酒相关的冠心病发病率、病死率及全因死亡率的相对风险等资料.应用荟萃分析,系统评价饮酒量与冠心病发病率、病死率及全国死亡率的风险效应.结果 纳入前瞻性队列研究15项;共计汇总冠心病研究对象177 723例,含冠心病患者2406例;全因死亡研究对象216 233例,含各种原因死亡15 462例.与不饮酒者比较,每日饮酒量≤20、21～40、41～60、＞60g/d者冠心病发病风险分别为0.65(95%CI:0.34～1.23,P=0.18)、0.48(95%CI:0.26～0.87,P=0.02)、0.46(95%CI:0.32～0.67,P＜0.01)和0.48(95%CI:0.29～0.78,P＜0.01),冠心病死亡风险分别为0.98(95%CI:0.73～1.31,P=0.87)、0.68(95%CI:0.58～0.79,P＜0.01)、0.64(95%CI:0.43～0.96,P=0.03)和0.75(95%CI:0.54～1.03,P=0.08),全因死亡风险分别为0.83(95%CI:0.79～0.91,P＜0.01)、0.93(95%CI:0.87～0.99,P=0.03)、1.01(95%CI:0.95～1.07,P=0.86)和1.32(95%CI:1.29～1.36,P＜0.01).结论 东亚男性适量饮酒可降低冠心病发病率及病死率.随着饮酒量增加,全因死亡的风险明显增加.每日饮用酒精量不应超过40g.
目的 探討東亞男性飲酒對冠心病髮病率、病死率和全因死亡率的影響.方法 檢索Pubmed等數據庫,納入中國、日本、韓國符閤入選條件的前瞻性隊列研究.記錄研究來源國傢,例數,性彆,年齡,隨訪期限,飲酒量,與飲酒相關的冠心病髮病率、病死率及全因死亡率的相對風險等資料.應用薈萃分析,繫統評價飲酒量與冠心病髮病率、病死率及全國死亡率的風險效應.結果 納入前瞻性隊列研究15項;共計彙總冠心病研究對象177 723例,含冠心病患者2406例;全因死亡研究對象216 233例,含各種原因死亡15 462例.與不飲酒者比較,每日飲酒量≤20、21～40、41～60、＞60g/d者冠心病髮病風險分彆為0.65(95%CI:0.34～1.23,P=0.18)、0.48(95%CI:0.26～0.87,P=0.02)、0.46(95%CI:0.32～0.67,P＜0.01)和0.48(95%CI:0.29～0.78,P＜0.01),冠心病死亡風險分彆為0.98(95%CI:0.73～1.31,P=0.87)、0.68(95%CI:0.58～0.79,P＜0.01)、0.64(95%CI:0.43～0.96,P=0.03)和0.75(95%CI:0.54～1.03,P=0.08),全因死亡風險分彆為0.83(95%CI:0.79～0.91,P＜0.01)、0.93(95%CI:0.87～0.99,P=0.03)、1.01(95%CI:0.95～1.07,P=0.86)和1.32(95%CI:1.29～1.36,P＜0.01).結論 東亞男性適量飲酒可降低冠心病髮病率及病死率.隨著飲酒量增加,全因死亡的風險明顯增加.每日飲用酒精量不應超過40g.
목적 탐토동아남성음주대관심병발병솔、병사솔화전인사망솔적영향.방법 검색Pubmed등수거고,납입중국、일본、한국부합입선조건적전첨성대렬연구.기록연구래원국가,례수,성별,년령,수방기한,음주량,여음주상관적관심병발병솔、병사솔급전인사망솔적상대풍험등자료.응용회췌분석,계통평개음주량여관심병발병솔、병사솔급전국사망솔적풍험효응.결과 납입전첨성대렬연구15항;공계회총관심병연구대상177 723례,함관심병환자2406례;전인사망연구대상216 233례,함각충원인사망15 462례.여불음주자비교,매일음주량≤20、21～40、41～60、＞60g/d자관심병발병풍험분별위0.65(95%CI:0.34～1.23,P=0.18)、0.48(95%CI:0.26～0.87,P=0.02)、0.46(95%CI:0.32～0.67,P＜0.01)화0.48(95%CI:0.29～0.78,P＜0.01),관심병사망풍험분별위0.98(95%CI:0.73～1.31,P=0.87)、0.68(95%CI:0.58～0.79,P＜0.01)、0.64(95%CI:0.43～0.96,P=0.03)화0.75(95%CI:0.54～1.03,P=0.08),전인사망풍험분별위0.83(95%CI:0.79～0.91,P＜0.01)、0.93(95%CI:0.87～0.99,P=0.03)、1.01(95%CI:0.95～1.07,P=0.86)화1.32(95%CI:1.29～1.36,P＜0.01).결론 동아남성괄량음주가강저관심병발병솔급병사솔.수착음주량증가,전인사망적풍험명현증가.매일음용주정량불응초과40g.
Objective To assess the dose-response relationship between alcohol consumption and relative risk of coronary heart disease (CHD) morbidity, mortality and all-cause mortality among Eastern Asian men. Methods Potential prospective cohort studies were retrieved by searching Pubmed (1966-2000), Biosis Previews (1980-2009), Embase (1980-2009) and ISI Web of Knowledge (1986-2009)using Medical Subject Headings alcohol drinking, ethanol, coronary heart (or artery) disease, myocardial infarction, mortality, etc; and Koreans,or Japanese or Chinese.From the 28 relevant retrieved reports,15 prospective cohort studies met the criteria were included.Information on study design,participant characteristics, level of alcohol consumption, CHD outcome, control for potential confounding factors, and risk estimates were abstracted using a standardized protocol.For each study, relative risks (RR) and 95% confidence intervals (CI) were extracted and pooled with either a fixed effect model or random effect model according to the result of the test of heterogeneity. Results Due to the limited available data for women,this study only comprised of 2406 cases of CHD among 177 723 male subjects.Findings were also pooled from 216 233 male subjects and 15 462 deaths from any cause. Compared with nondrinkers, the RRs on CHD morbidity for those who drank alcohol≤20, 21-40, 41-60,＞60g/d were 0.65 (0.34-1.23,P=0.18), 0.48 (0.26-0.87,P=0.02), 0.46 (0.32-0.67,P＜0.01),and 0.48(0.29-0.78,P＜0.01 ) respectively; the RRs on CHD mortality were 0. 98 (0.73-1.31 ,P=0.87), 0.68 (0.58-0.79,P＜0.01), 0.64 (0.43-0.96,P=0.03), 0.75 (0.54-1.03,P=0.08); and on all-cause mortality were 0.83 (0.79-0.91, P＜0.01), 0.93 (0.87-0.99, P=0.03), 1.01 (0.95-1.07, P=0.86),1.32 (1.29-1.36, P＜ 0.01 ). Conclusion Light-to-moderate alcohol intake was associated with decreased risk of CHD morbidity and mortality, while heavy alcohol intake was associated with increased allcause mortality among Eastern Asian men.
