中国实用医刊
中國實用醫刊
중국실용의간
CENTRAL PLAINS MEDICAL JOURNAL
2012年
9期
28-29
,共2页
糖尿病肾病%福辛普利%辛伐他汀
糖尿病腎病%福辛普利%辛伐他汀
당뇨병신병%복신보리%신벌타정
Diabetic nephropathy%Fosinopril%Simvastatin
目的 研究福辛普利单用及与辛伐他汀联用对糖尿病肾病患者的肾脏保护作用.方法 将60例糖尿病肾病患者随机分为两组.福辛普利组30例,给予福辛普利10mg,口服,1次/d；联合用药组30例,给予辛伐他汀与福辛普利,辛伐他汀20mg,口服,1次/d,福辛普利用法同前组.疗程均为24周,观察两组治疗前后的尿白蛋白排泄率(UAER)、内生肌酐清除率(Ccr)、血脂、血压等指标.结果 治疗后两组UAER与尿蛋白均降低,血清白蛋白升高(P＜0.01).联合用药组UAER降低,降低幅度大于福辛普利组(P＜0.01),尿蛋白降低与血清蛋白增长幅度联合用药组大于福辛普利组(P＜0.01).两组Ccr与空腹血糖均下降,差异无统计学意义(P＞0.05).两组血脂和血压降低均有所改善(P＜0.01),联合用药组血脂改变程度优于福辛普利组(P＜0.0l).结论 福辛普利与辛伐他汀联用治疗糖尿病肾病,对肾脏保护有协同作用.
目的 研究福辛普利單用及與辛伐他汀聯用對糖尿病腎病患者的腎髒保護作用.方法 將60例糖尿病腎病患者隨機分為兩組.福辛普利組30例,給予福辛普利10mg,口服,1次/d；聯閤用藥組30例,給予辛伐他汀與福辛普利,辛伐他汀20mg,口服,1次/d,福辛普利用法同前組.療程均為24週,觀察兩組治療前後的尿白蛋白排洩率(UAER)、內生肌酐清除率(Ccr)、血脂、血壓等指標.結果 治療後兩組UAER與尿蛋白均降低,血清白蛋白升高(P＜0.01).聯閤用藥組UAER降低,降低幅度大于福辛普利組(P＜0.01),尿蛋白降低與血清蛋白增長幅度聯閤用藥組大于福辛普利組(P＜0.01).兩組Ccr與空腹血糖均下降,差異無統計學意義(P＞0.05).兩組血脂和血壓降低均有所改善(P＜0.01),聯閤用藥組血脂改變程度優于福辛普利組(P＜0.0l).結論 福辛普利與辛伐他汀聯用治療糖尿病腎病,對腎髒保護有協同作用.
목적 연구복신보리단용급여신벌타정련용대당뇨병신병환자적신장보호작용.방법 장60례당뇨병신병환자수궤분위량조.복신보리조30례,급여복신보리10mg,구복,1차/d；연합용약조30례,급여신벌타정여복신보리,신벌타정20mg,구복,1차/d,복신보이용법동전조.료정균위24주,관찰량조치료전후적뇨백단백배설솔(UAER)、내생기항청제솔(Ccr)、혈지、혈압등지표.결과 치료후량조UAER여뇨단백균강저,혈청백단백승고(P＜0.01).연합용약조UAER강저,강저폭도대우복신보리조(P＜0.01),뇨단백강저여혈청단백증장폭도연합용약조대우복신보리조(P＜0.01).량조Ccr여공복혈당균하강,차이무통계학의의(P＞0.05).량조혈지화혈압강저균유소개선(P＜0.01),연합용약조혈지개변정도우우복신보리조(P＜0.0l).결론 복신보리여신벌타정련용치료당뇨병신병,대신장보호유협동작용.
Objective To investigate the renal protective effects of fosinopril used alone and combination with simvastatin on patients with diabetic nephropathy.Methods Sixty patients with diabetic nephropating were randomly divided into two groups:30 patients in fosinopril group were treated with fosinopril 10 mg,po,qd; 30 patients in combination therapy group were treated with simvastation 20 mg,po,qd and fosinopril 10 mg,po,qd.The course of treatment was 24 weeks.The urinary albumin excretion rate (UAER),serum albumin(Alb),creatinine clearance(Ccr),serum creatinine(Scr),blood lipid and blood pressure were observed and recorded before and after the treatment.Results After the treatment,UAER,urine protein(UPT) decreased and the Alb increased in the two groups (P ＜ 0.01).But the UAER decreased in combination therapy group was better than that in fosinopril group group (P ＜ 0.01).Reduction of UPT and the Alb increased in combination therapy group were more than those in the fosinopril group (P ＜ 0.01).The Ccr and fasting blood glucose decreased in all groups,there was no significant difference between them (P ＞ 0.05).The blood lipid and pressure improved in two groups (P ＜ 0.01),especially in combination therapy group.Conclusions The combination treatment of simvastatin and fosinopril has synergestic effect on renal function protection in the treatment of diabetic nephropathy.
