CAJ | 학술논문

目的本研究旨在探讨全身性的高频率低能量振动对骨折愈合的作用.方法建立大鼠闭合性股骨骨折髓内固定模型(n=55),并随机分为治疗组(n=28)和对照组(n=27).骨折后第5天开始对治疗组使用高频率低能量振动平台(35 Hz,峰振幅0.3 g)治疗,对照组则行假治疗.采用二维(X线)及三维(显微计算机断层扫描)的影像学方法和生物力学测试对骨折愈合的情况进行评估,并行统计学比较分析.结果治疗后2周治疗组新生的矿化骨痂在上维及三维定量分析中均明显多于对照组,差异有统计学意义(P<0.001和P=0.014).治疗后4周治疗组的骨折愈合率(85.7%)高于对照组(57.1%),骨折愈合的生物力学属性也优于埘照组,差异有统计学意义(P=0.023).结论高频率低能量振动可刺激骨折部位骨痂的生成及矿化,从而促进骨折愈合.
목적 본연구지재탐토전신성적고빈솔저능량진동대골절유합적작용.방법 건립대서폐합성고골골절수내고정모형(n=55),병수궤분위치료조(n=28)화대조조(n=27).골절후제5천개시대치료조사용고빈솔저능량진동평태(35 Hz,봉진폭0.3 g)치료,대조조칙행가치료.채용이유(X선)급삼유(현미계산궤단층소묘)적영상학방법화생물역학측시대골절유합적정황진행평고,병행통계학비교분석.결과 치료후2주치료조신생적광화골가재상유급삼유정량분석중균명현다우대조조,차이유통계학의의(P<0.001화P=0.014).치료후4주치료조적골절유합솔(85.7%)고우대조조(57.1%),골절유합적생물역학속성야우우시조조,차이유통계학의의(P=0.023).결론 고빈솔저능량진동가자격골절부위골가적생성급광화,종이촉진골절유합.
Objective To investigated the effects of whole-body low-magnitude high-frequency vibration (LMHFV), a form of biophysical intervention, on fracture healing. Methods Closed femoral shaft fracture with intramedullary fixation was established in 55 SD rats. Effects of LMHFV treatment on fracture healing were assessed through comparison with the sham control. Assessments included two- and three-dimensional quantification of mineralized callus formation using plain radiography and micro-CT.Mechanical outcomes were checked with four-point-bending tests. Results Radiography as well as micro-CT showed significantly larger amount of mineralized callus in the treatment group, together with a significantly faster remodeling process of the callus into mature bone. The mechanical strength of the healed fracture was significantly greater after 4 weeks of treatment compared with the control. Conclusions LMHFV enhances healing of the closed femoral shaft fracture in rats. Its potential clinical advantages shall be confirmed in the subsequent clinical trials.