中国医药
中國醫藥
중국의약
CHINA MEDICINE
2010年
11期
976-978
,共3页
高血压%抗抑郁药%可重复性,结果%心理疗法%Meta分析
高血壓%抗抑鬱藥%可重複性,結果%心理療法%Meta分析
고혈압%항억욱약%가중복성,결과%심리요법%Meta분석
Hypertension%Antidepressive agents%Reproducibilty of Results%Psychotherapy%Metaanalysis
目的 了解应用综合疗法(降压药联合抗焦虑、抗抑郁心理治疗)治疗高血压病伴焦虑、抑郁患者的疗效. 方法 系统检索Pubmed,中文期刊全文数据库,万方数据库以及Internet公开发表的文献.检索词为高血压、焦虑、抑郁(主题题与自由词组合).应用Meta分析文献中对于高血压病伴焦虑、抑郁患者,应用综合疗法的有效性进行同质性和异质性检验及合并效应量的估计. 结果 共收集到相关文献76篇,其中符合纳入标准的有20篇;14项研究总有效例数合并OR值为2.85[95% CI2.17～3.73],11项研究的收缩压合并标准化均数差值(SMD)为-1.13[95%CI-1.67～-0.58],舒张压合并SMD为-1.17[95%CI-1.87～-0.46]. 结论 应用综合疗法治疗高血压病伴焦虑、抑郁患者的疗效总体上明显高于单纯降压治疗组.
目的 瞭解應用綜閤療法(降壓藥聯閤抗焦慮、抗抑鬱心理治療)治療高血壓病伴焦慮、抑鬱患者的療效. 方法 繫統檢索Pubmed,中文期刊全文數據庫,萬方數據庫以及Internet公開髮錶的文獻.檢索詞為高血壓、焦慮、抑鬱(主題題與自由詞組閤).應用Meta分析文獻中對于高血壓病伴焦慮、抑鬱患者,應用綜閤療法的有效性進行同質性和異質性檢驗及閤併效應量的估計. 結果 共收集到相關文獻76篇,其中符閤納入標準的有20篇;14項研究總有效例數閤併OR值為2.85[95% CI2.17～3.73],11項研究的收縮壓閤併標準化均數差值(SMD)為-1.13[95%CI-1.67～-0.58],舒張壓閤併SMD為-1.17[95%CI-1.87～-0.46]. 結論 應用綜閤療法治療高血壓病伴焦慮、抑鬱患者的療效總體上明顯高于單純降壓治療組.
목적 료해응용종합요법(강압약연합항초필、항억욱심리치료)치료고혈압병반초필、억욱환자적료효. 방법 계통검색Pubmed,중문기간전문수거고,만방수거고이급Internet공개발표적문헌.검색사위고혈압、초필、억욱(주제제여자유사조합).응용Meta분석문헌중대우고혈압병반초필、억욱환자,응용종합요법적유효성진행동질성화이질성검험급합병효응량적고계. 결과 공수집도상관문헌76편,기중부합납입표준적유20편;14항연구총유효례수합병OR치위2.85[95% CI2.17～3.73],11항연구적수축압합병표준화균수차치(SMD)위-1.13[95%CI-1.67～-0.58],서장압합병SMD위-1.17[95%CI-1.87～-0.46]. 결론 응용종합요법치료고혈압병반초필、억욱환자적료효총체상명현고우단순강압치료조.
Objective To study the efficacy of anti-depression therapy in patients with hypertension and depression and to find the optimized treatment protocol. Methods The efficacy of anti-depression therapy in patients with hypertension and depression were comprehensively evaluated with meta-analysis in homogeneity tests and combined tests in 20 studies. Results Seventy six trials were collected ,20 trials involving 1783 patients were included.Combined OR of efficient rate of 14 trials was 2.85 and its 95% confidence interval(CI)was [95% CI 2.17 ～3.73],and based on 11 trials weighted mean difference(WMD)of systolic blood pressure was -1.13[95% CI -1.67～0.58],WMD of diastolic blood pressure was -1.17[95% CI-1.87 ～ -0.46]. Conclusion Anti-depression therapy has a promising effect in treating hypertension patient with depression.
