CAJ | 학술논문

目的探讨PTEN基因、基质金属蛋白酶(MMP)-2和MMP-9在胸腺瘤中的表达及其与胸腺瘤临床病理特征的关系.方法应用免疫组织化学SP方法,检测45例胸腺瘤和16例非瘤胸腺(对照组)组织中PTEN、MMP-2和MMP-9的表达.结果 PTEN、MMP-2和MMP-9在胸腺瘤组织中的阳性表达率分别为53.5%、48.9%和62.2%,在对照组中的阳性表达率分别为93.8%、6.3%和25.0%,差异均有统计学意义(P<0.05).PTEN和MMP-2的表达与胸腺瘤的恶性程度(世界卫生组织分型)有关(P<0.05),与胸腺瘤的侵袭性(Masaoka分期)有关(P<0.01).MMP-9的表达与胸腺瘤的恶性程度和侵袭性无关(P>0.05).结论 PTEN、MMP-2和MMP-9与胸腺瘤的发生、发展可能有关,且PTEN和MMP-2与胸腺瘤的恶性程度和侵袭性相关.
목적 탐토PTEN기인、기질금속단백매(MMP)-2화MMP-9재흉선류중적표체급기여흉선류림상병리특정적관계.방법 응용면역조직화학SP방법,검측45례흉선류화16례비류흉선(대조조)조직중PTEN、MMP-2화MMP-9적표체.결과 PTEN、MMP-2화MMP-9재흉선류조직중적양성표체솔분별위53.5%、48.9%화62.2%,재대조조중적양성표체솔분별위93.8%、6.3%화25.0%,차이균유통계학의의(P<0.05).PTEN화MMP-2적표체여흉선류적악성정도(세계위생조직분형)유관(P<0.05),여흉선류적침습성(Masaoka분기)유관(P<0.01).MMP-9적표체여흉선류적악성정도화침습성무관(P>0.05).결론 PTEN、MMP-2화MMP-9여흉선류적발생、발전가능유관,차PTEN화MMP-2여흉선류적악성정도화침습성상관.
Objective To evaluate the expression of PTEN, MMP-2 and MMP-9 in thymomas and their correlation with clinical significance. Methods lmmunohistochemical S-P assay was used to detect the expression of PTEN, MMP-2 and MMP-9 in 45 thymomas and 16 non-neoplastic thymuses. Results The positive rate of PTEN, MMP-2 and MMP-9 expression in 45 thymomas were 53.5% , 48.9% and 62.2% ,respectively. There were significant differences between non-neoplastic thymus and thymomas (P < 0. 05 ).The expression of PTEN, MMP-2 correlated with histological type (P<0. 05) and different clinical stage of the thymoma (P<0.01 ). The expression of MMP-9 was not correlated with histological type and different clinical stages of thymoma (P >0. 05). Conclusion PTEN, MMP-2 and MMP-9 may play an important role in the occurrence and development of thymoma. The expression of PTEN and MMP-2 correlates with the malignance and the aggression of thymoma.