临床耳鼻咽喉头颈外科杂志
臨床耳鼻嚥喉頭頸外科雜誌
림상이비인후두경외과잡지
JOURNAL OF CLINICAL OTORHINOLARYNGOLOGY HEAD AND NECK SURGERY
2009年
20期
933-935
,共3页
梁锦辉%高山%张剑%敖红敏%魏显林%罗海林
樑錦輝%高山%張劍%敖紅敏%魏顯林%囉海林
량금휘%고산%장검%오홍민%위현림%라해림
鼻肿瘤%内翻性乳头状瘤%Survivin%Bcl-2
鼻腫瘤%內翻性乳頭狀瘤%Survivin%Bcl-2
비종류%내번성유두상류%Survivin%Bcl-2
nose neoplasms%inverted papilloma%Survivin%Bcl-2
目的:探讨细胞凋亡抑制蛋白Survivin在鼻腔鼻窦内翻性乳头状瘤中的表达及其与Bcl-2表达的相关性.方法:采用免疫组织化学Envision二步法检测30例鼻腔鼻窦内翻性乳头状瘤, 10例鼻腔鳞状细胞癌及10例正常下鼻甲黏膜标本中Survivin和Bcl-2的表达.结果:鼻腔鼻窦内翻性乳头状瘤和鼻腔鳞状细胞癌组织中Survivin的表达分别为73.3%和80.0%,均显著高于正常下鼻甲黏膜组织(均P<0.01).鼻腔鳞状细胞癌组织中Bcl-2的表达率为90.0%,显著高于正常下鼻甲黏膜组织的表达率(20.0%)(P<0.01).鼻腔鼻窦内翻性乳头状瘤组织中Bcl-2的表达率为46.7%,高于正常下鼻甲黏膜,但两者之间的差异无统计学意义(P>0.05).Survivin表达与Bcl-2表达呈正相关(P<0.01).结论:Survivin在鼻腔鼻窦内翻性乳头状瘤和鼻腔鳞状细胞癌的发生、发展中起重要作用,可能成为鼻腔鼻窦内翻性乳头状瘤和鼻腔鳞状细胞癌基因治疗的靶点.Survivin可能与Bcl-2在鼻腔内翻性乳头状瘤的发展中起协同作用.
目的:探討細胞凋亡抑製蛋白Survivin在鼻腔鼻竇內翻性乳頭狀瘤中的錶達及其與Bcl-2錶達的相關性.方法:採用免疫組織化學Envision二步法檢測30例鼻腔鼻竇內翻性乳頭狀瘤, 10例鼻腔鱗狀細胞癌及10例正常下鼻甲黏膜標本中Survivin和Bcl-2的錶達.結果:鼻腔鼻竇內翻性乳頭狀瘤和鼻腔鱗狀細胞癌組織中Survivin的錶達分彆為73.3%和80.0%,均顯著高于正常下鼻甲黏膜組織(均P<0.01).鼻腔鱗狀細胞癌組織中Bcl-2的錶達率為90.0%,顯著高于正常下鼻甲黏膜組織的錶達率(20.0%)(P<0.01).鼻腔鼻竇內翻性乳頭狀瘤組織中Bcl-2的錶達率為46.7%,高于正常下鼻甲黏膜,但兩者之間的差異無統計學意義(P>0.05).Survivin錶達與Bcl-2錶達呈正相關(P<0.01).結論:Survivin在鼻腔鼻竇內翻性乳頭狀瘤和鼻腔鱗狀細胞癌的髮生、髮展中起重要作用,可能成為鼻腔鼻竇內翻性乳頭狀瘤和鼻腔鱗狀細胞癌基因治療的靶點.Survivin可能與Bcl-2在鼻腔內翻性乳頭狀瘤的髮展中起協同作用.
목적:탐토세포조망억제단백Survivin재비강비두내번성유두상류중적표체급기여Bcl-2표체적상관성.방법:채용면역조직화학Envision이보법검측30례비강비두내번성유두상류, 10례비강린상세포암급10례정상하비갑점막표본중Survivin화Bcl-2적표체.결과:비강비두내번성유두상류화비강린상세포암조직중Survivin적표체분별위73.3%화80.0%,균현저고우정상하비갑점막조직(균P<0.01).비강린상세포암조직중Bcl-2적표체솔위90.0%,현저고우정상하비갑점막조직적표체솔(20.0%)(P<0.01).비강비두내번성유두상류조직중Bcl-2적표체솔위46.7%,고우정상하비갑점막,단량자지간적차이무통계학의의(P>0.05).Survivin표체여Bcl-2표체정정상관(P<0.01).결론:Survivin재비강비두내번성유두상류화비강린상세포암적발생、발전중기중요작용,가능성위비강비두내번성유두상류화비강린상세포암기인치료적파점.Survivin가능여Bcl-2재비강내번성유두상류적발전중기협동작용.
Objective:To investigate the expression of Survivin and it's relationship with the expression of Bcl-2 in sinonasal inverted papilloma (SNIP).Method:Immunohistochemical method was used to determine the expression of Survivin and Bcl-2 in 30 cases of SNIP,10 cases of sinonasal squamous cell carcinoma(SCC) and 10 cases of normal inferior concha tissues.Result:Survivin was expressed in 22 of 30(73.3%)cases of SNIP,8 of 10(80.0%)cases of SCC and not expressed in 10(0%)cases of normal inferior concha tissues.Expression of Survivin was significantly higher in SNIP and SCC than in normal tissues.Bcl-2 was expressed in 9 of 10(90.0%)cases of SCC and 2 of 10(20.0%)cases of normal inferior concha tissues.Expression of Bcl-2 was significantly higher in SCC than in normal tissues.Bcl-2 was expressed in 14 of 30(46.7%)cases of SNIP,higher than normal tissues.Expression of Bcl-2 was positively related to expression of Survivin.Conclusion:Survivin may play an important role in the pathway of progression of SNIP and SCC.It may be identified as a new therapeutic target.Bcl-2 may play a synergic role with Survivin in progression of SNIP.
