国际呼吸杂志
國際呼吸雜誌
국제호흡잡지
INTERNATIONAL JOURNAL OF RESPIRATION
2009年
15期
905-908
,共4页
丁立君%阎锡新%宋贝贝%关继涛
丁立君%閻錫新%宋貝貝%關繼濤
정립군%염석신%송패패%관계도
慢性阻塞性肺疾病%膈肌功能%脂多糖%控制机械通气%被动吸烟
慢性阻塞性肺疾病%膈肌功能%脂多糖%控製機械通氣%被動吸煙
만성조새성폐질병%격기공능%지다당%공제궤계통기%피동흡연
Chronic obstructive pulmonary disease%Diaphragmatic function%Lipopolysaccharide Controlled mechanical ventilation%Passive smoking
目的 以慢性阻塞性肺疾病(chronic obstructive pulmonary disease,COPD)模型大鼠为研究对象,探讨膈肌功能及短期控制性机械通气对膈肌功能的影响.方法 应用气管内滴注脂多糖联合被动吸烟的方法 复制大鼠COPD模型,比较正常大鼠与COPD大鼠跨膈压及膈肌肌电图频谱变化;对COPD模型组大鼠行短期控制机械通气,观察其膈肌功能的变化.结果 COPD模型组大鼠肺功能与正常对照组比较FEV0.3/FVC[(88.05±5.87)%vs(69.41±11.50)%]显著下降(P<0.05).COPD模型组大鼠跨膈压与正常对照组相比[(4.28±1.03)cm H2Ovs(5.36±0.94)cm H20]显著下降(P<0.05),说明COPD模型组大鼠呼吸肌力较正常对照组下降.COPD模型组大鼠较正常对照组大鼠的膈肌肌电高低频比值(%)(4.99±2.36 vs 3.12±1.10)下降显著(P<0.05),低频部分显著增加(P<0.05).COPD模型组大鼠机械通气(6 h)前后跨膈压及肌电图频谱分析结果 差异无统计学意义.结论 COPD模型组大鼠跨膈压较对照组减小,膈肌肌电图频谱分析高低频比值下降.说明其膈肌功能下降.短期(6 h)控制机械通气对COPD大鼠膈肌功能无显著影响.
目的 以慢性阻塞性肺疾病(chronic obstructive pulmonary disease,COPD)模型大鼠為研究對象,探討膈肌功能及短期控製性機械通氣對膈肌功能的影響.方法 應用氣管內滴註脂多糖聯閤被動吸煙的方法 複製大鼠COPD模型,比較正常大鼠與COPD大鼠跨膈壓及膈肌肌電圖頻譜變化;對COPD模型組大鼠行短期控製機械通氣,觀察其膈肌功能的變化.結果 COPD模型組大鼠肺功能與正常對照組比較FEV0.3/FVC[(88.05±5.87)%vs(69.41±11.50)%]顯著下降(P<0.05).COPD模型組大鼠跨膈壓與正常對照組相比[(4.28±1.03)cm H2Ovs(5.36±0.94)cm H20]顯著下降(P<0.05),說明COPD模型組大鼠呼吸肌力較正常對照組下降.COPD模型組大鼠較正常對照組大鼠的膈肌肌電高低頻比值(%)(4.99±2.36 vs 3.12±1.10)下降顯著(P<0.05),低頻部分顯著增加(P<0.05).COPD模型組大鼠機械通氣(6 h)前後跨膈壓及肌電圖頻譜分析結果 差異無統計學意義.結論 COPD模型組大鼠跨膈壓較對照組減小,膈肌肌電圖頻譜分析高低頻比值下降.說明其膈肌功能下降.短期(6 h)控製機械通氣對COPD大鼠膈肌功能無顯著影響.
목적 이만성조새성폐질병(chronic obstructive pulmonary disease,COPD)모형대서위연구대상,탐토격기공능급단기공제성궤계통기대격기공능적영향.방법 응용기관내적주지다당연합피동흡연적방법 복제대서COPD모형,비교정상대서여COPD대서과격압급격기기전도빈보변화;대COPD모형조대서행단기공제궤계통기,관찰기격기공능적변화.결과 COPD모형조대서폐공능여정상대조조비교FEV0.3/FVC[(88.05±5.87)%vs(69.41±11.50)%]현저하강(P<0.05).COPD모형조대서과격압여정상대조조상비[(4.28±1.03)cm H2Ovs(5.36±0.94)cm H20]현저하강(P<0.05),설명COPD모형조대서호흡기력교정상대조조하강.COPD모형조대서교정상대조조대서적격기기전고저빈비치(%)(4.99±2.36 vs 3.12±1.10)하강현저(P<0.05),저빈부분현저증가(P<0.05).COPD모형조대서궤계통기(6 h)전후과격압급기전도빈보분석결과 차이무통계학의의.결론 COPD모형조대서과격압교대조조감소,격기기전도빈보분석고저빈비치하강.설명기격기공능하강.단기(6 h)공제궤계통기대COPD대서격기공능무현저영향.
Objective To explore diaphragmatic function and the influence of controlled mechanical ventilation on diaphragmatic function in chronic obstructive pulmonary disease(COPD) model rats. Methods Dripping lipopolysaccharide applied to trachea and passive smoking were applied to replicate the model of COPD; the changes of trans-diaphragmatic pressure and spectrum analysis of electromyogram of diaphragmatic muscle in normal rats and COPD rats were compared; the effect of short term controlled mechanical ventilation on diaphragmatic function of COPD rats was observed. Results FEVo.s/FVC decreased in rats in model group compared with that in normal group (88. 05±5.87)% vs (69.41± 11.50)% (P <0.05). The transdiaphragmatic pressure of model group was lower than that of control group (4. 28±1.03) cm H2O vs (5.36±0.94) cm H2O (P <0.05). Results of spectral analysis of electromyographic signal of diaphragmatic muscle in ratio by high frequency and low frequency were lower in model group than those in control group (P < 0.05). However, it was increased significantly in low frequency in model group. Results of trans-diaphragmatic pressure and spectrum analysis of etectromyographic signal of diaphragmatic muscle before and after mechanical ventilation in rats of COPD model were of no significant difference ( P < 0.05). Conclusions By trans-diaphragmatic pressure and spectrum analysis of electromyographic signal of diaphragmatic muscle measuring, it is indicated that diaphragmatic function decreases in rats with COPD. Short term (6 hours ) controlled mechanical ventilation has no significant effect on diaphragmatic function in rats with COPD.
