国际肿瘤学杂志
國際腫瘤學雜誌
국제종류학잡지
JOURNAL OF INTERNATIONAL ONCOLOGY
2011年
5期
323-326
,共4页
肿瘤%受体,血管内皮生长因子%信号转导
腫瘤%受體,血管內皮生長因子%信號轉導
종류%수체,혈관내피생장인자%신호전도
Neoplasms%Receptors,vascular endothelial growth factor%Signal transduction
抗肿瘤血管发生是一种全新的抗肿瘤治疗策略,目前研究最多的是寻找有效抗血管内皮生长因子(VEGF)信号通路的药物.然而VEGF抑制剂并不是对所有肿瘤有效,因此,有必要进一步探索血管发生的其他信号通路.目前,Dll4-Notch信号通路被认为是抗肿瘤血管发生的新靶点,而且VEGF和Dll4-Notch信号通路在多方面相互作用,在调控血管发生过程中发挥重要作用,对这两条通路的探索和研究,将会使治疗肿瘤的手段更为丰富.
抗腫瘤血管髮生是一種全新的抗腫瘤治療策略,目前研究最多的是尋找有效抗血管內皮生長因子(VEGF)信號通路的藥物.然而VEGF抑製劑併不是對所有腫瘤有效,因此,有必要進一步探索血管髮生的其他信號通路.目前,Dll4-Notch信號通路被認為是抗腫瘤血管髮生的新靶點,而且VEGF和Dll4-Notch信號通路在多方麵相互作用,在調控血管髮生過程中髮揮重要作用,對這兩條通路的探索和研究,將會使治療腫瘤的手段更為豐富.
항종류혈관발생시일충전신적항종류치료책략,목전연구최다적시심조유효항혈관내피생장인자(VEGF)신호통로적약물.연이VEGF억제제병불시대소유종류유효,인차,유필요진일보탐색혈관발생적기타신호통로.목전,Dll4-Notch신호통로피인위시항종류혈관발생적신파점,이차VEGF화Dll4-Notch신호통로재다방면상호작용,재조공혈관발생과정중발휘중요작용,대저량조통로적탐색화연구,장회사치료종류적수단경위봉부.
Anti-angiogenesis therapies have emerged as new treatment strategies for several types of tumors. To date, the most studied programs are to find out effective medicines to block the vascular endothelial growth factor (VEGF) signaling pathway. However, VEGF inhibitors are not effective to all kinds of tumors.Thus there is a need to explore other angiogenesis signaling pathways. Recently, the Dll4-Notch pathway was identified as a new target in tumor angiogenesis. Moreover, an important feature in angiogenesis is the manifold ways in which the VEGF and Dll4-Notch pathways interact each other, which play critical roles in tumor angiogenesis. Therefore, the further exploration of these two pathways will provide more therapies for clinic to treat tumors.
