CAJ | 학술논문

目的探讨慢性荨麻疹患者食物过敏原检测的意义.方法对502例慢性荨麻疹患者进行食物过敏原特异性IgE与IgG检测,并进行统计学分析；同时对花生、黄豆、牛奶等过敏原的特异性IgE与IgG不同结果组进行双盲安慰剂食物激发试验.结果 188例患者食物过敏原特异性IgE阳性,阳性检出率为37.4％,其中腰果、花生黄豆阳性率较高；362例患者至少对1种食物过敏,IgG阳性检出率为72.1％,牛奶、鸡蛋、虾蟹为主要过敏原.双盲安慰剂食物激发试验证实,两种抗体检测都有假阳性与假阴性.结论临床医生应在慢性荨麻疹的治疗中注意筛查食物过敏原,特别是IgG介导的过敏反应.
목적 탐토만성담마진환자식물과민원검측적의의.방법 대502례만성담마진환자진행식물과민원특이성IgE여IgG검측,병진행통계학분석；동시대화생、황두、우내등과민원적특이성IgE여IgG불동결과조진행쌍맹안위제식물격발시험.결과 188례환자식물과민원특이성IgE양성,양성검출솔위37.4％,기중요과、화생황두양성솔교고；362례환자지소대1충식물과민,IgG양성검출솔위72.1％,우내、계단、하해위주요과민원.쌍맹안위제식물격발시험증실,량충항체검측도유가양성여가음성.결론 림상의생응재만성담마진적치료중주의사사식물과민원,특별시IgG개도적과민반응.
Objective To evaluate the roles of food allergen detection in patients with chronic urticaria.Methods Food allergen-specific IgE and IgG were detected in 502 patients with chronic urticaria and 100 normal human controls.Double-blind,placebo-controlled food challenge (DBPCFC) test was performed in patients who were proved to be positive or negative for food-specific IgG or IgE.Results Food-specific IgE was detected in 37.45％ (188/502) of the patients,with cashew,peanuts and soybeans as the most common allergens.The detection rate of food-specific IgG was 72.11％ (361/502),with the major allergens being milk,egg,shrimp and crab.DBPCFC revealed false positivity and negativity in the detection of food-specific IgG and IgE.Conclusions Clinicians should pay attention to food allergen detection in the treatment of chronic urticaria,especially in the treatment of allergy mediated by IgG antibodies.