CAJ | 학술논문

缺氧诱导因子(HIF)是调节机体氧稳态的主要转录因子.在缺氧环境下,HIF调节许多目的基冈的表达,这些基因表达的蛋白产物在血管再生、能量代谢、炎症反应和细胞存活方面起了重要作用.无论是在生理还是病理生理的情况下,肺部都可能出现局部或全肺的缺氧,此外,实验和临床数据均表明HIF与诸如肺损伤、肺动脉高压、肺肿瘤等肺疾病的发病机制有关.因此,研究HIF在肺疾病中的作用有非常重大的意义.
결양유도인자(HIF)시조절궤체양은태적주요전록인자.재결양배경하,HIF조절허다목적기강적표체,저사기인표체적단백산물재혈관재생、능량대사、염증반응화세포존활방면기료중요작용.무론시재생리환시병리생리적정황하,폐부도가능출현국부혹전폐적결양,차외,실험화림상수거균표명HIF여제여폐손상、폐동맥고압、폐종류등폐질병적발병궤제유관.인차,연구HIF재폐질병중적작용유비상중대적의의.
Hypoxia-inducible factor (HIF) is a transcription factor that functions as a master regulator of oxygen homeostasis. Under hypoxic condition, HIF has been shown to regulate the expression of dozens of target genes,the protein products of which play important roles in angiogenesis,energy metabolism,inflammation,and cell survival.There are numerous instance,in both physiologic and pathophysiologic conditions,during which the lung experiences localized or global hypoxia. In addition,HIF has been implicated in the pathogenesis of lung diseases such as lung injury,pulmonary hypertention and lung cancer based on both experimental and clinical data.Therefore,aualyzing the role of HIF in lung diseases is of momentous significance.