CAJ | 학술논문

目的观察他汀类药物对血脂正常的老年单纯收缩期高血压(ISH)患者脉压及动脉弹性的影响.方法随机将68例ISH患者分成治疗组及对照组,对照组给予贝那普利口服,每次10 mg,1次/d;治疗组在对照组治疗基础上加用洛伐他汀,20 mg/次,每晚1次,观察两组患者治疗前后收缩压(SBP)、舒张压(DBP)、脉压(PP)、颈动脉-挠动脉脉博波速度(C-RPWV)及颈动脉-股动脉脉搏波速度(C-FPWV)的变化.结果治疗后两组SBP、PP、C-RPW及CFPWV均有所下降,随着治疗时间的延长,治疗组较对照组PP、C-RPWV及C-FPWV显著降低(P<0.01).结论他汀类与血管紧张素转换酶抑制剂合用,有益于控制患者的脉压及脉搏波速度,改善动脉弹性.
목적 관찰타정류약물대혈지정상적노년단순수축기고혈압(ISH)환자맥압급동맥탄성적영향.방법 수궤장68례ISH환자분성치료조급대조조,대조조급여패나보리구복,매차10 mg,1차/d;치료조재대조조치료기출상가용락벌타정,20 mg/차,매만1차,관찰량조환자치료전후수축압(SBP)、서장압(DBP)、맥압(PP)、경동맥-뇨동맥맥박파속도(C-RPWV)급경동맥-고동맥맥박파속도(C-FPWV)적변화.결과 치료후량조SBP、PP、C-RPW급CFPWV균유소하강,수착치료시간적연장,치료조교대조조PP、C-RPWV급C-FPWV현저강저(P<0.01).결론타정류여혈관긴장소전환매억제제합용,유익우공제환자적맥압급맥박파속도,개선동맥탄성.
Objective To observe the effects of the statin drugs on pulse pressure and arterial flexibil-ity in elderly isolated systolic hypertension(ISH) patients with normal blood lipids. Methods 68 ISH patients were randomly divided into treatment group and control group, patients in the control group were given benazepril 10 mg/d,once ,while the ones in the treatment group, based on the control group's therapy, were additionally used lovastatin,20 mg in every evening. Observe the chang of their, systolic blood pressure (SBP), diastolic blood pressure (DBP), pulse pressure (PP), carotid-radial pulse wave velocity (C-RPWV) and carotid-femoral pulse wave velocity(C-FPWV) from the twe groups before and after treatment. Results After treatment,in both groups, SBP, PP, C-RPW and C-FPWV has all declined, with the treatment time going, a significantly decline in patients'PP,C-RPWV and C-FPWV can be easily obtained,when compared with the control(P<0.01). Con-clusion The combination of statins and angiotensin-converting enzyme inhibitor is beneficial control patients' pulse pressure and pulse wave velocity as well as improve arterial flexibility.