CAJ | 학술논문

目的探讨Ⅲa期非小细胞肺癌的有效治疗方法.方法将53例Ⅲa期非小细胞肺癌患者分为观察组(26例)和对照组(27例).观察组术中用吡柔比星(THP)10 mg、环磷酰胺(CTX)200 mg、卡铂(CBP)50 mg置入清扫淋巴结处,以及术后行胸腔灌注吡柔比星50 mg、环磷酰胺600 mg、卡铂水针300 mg、α-干扰素500万U.两组均于手术后第3周采用紫杉醇(PTX)+THP+CBP/顺铂(DDP)或吉西他滨(GEM)+CBP/DDP及PTX+奥沙利铂(L-OHP)或异长春花碱(NVB)+L-OHP等多种方案交替静脉联合化疗,4周为一疗程,共4-6个疗程.随访3年进行疗效比较.结果观察组1、2、3年生存率分别为88.4%、76.9%和46.1%,对照组依次为77.8%、44.4%和33.3%.结论 Ⅲa期非小细胞肺癌手术并术中置药术后胸腔灌注,辅以早期联合静脉化疗,可提高患者生活质量及生存率.
목적 탐토Ⅲa기비소세포폐암적유효치료방법.방법 장53례Ⅲa기비소세포폐암환자분위관찰조(26례)화대조조(27례).관찰조술중용필유비성(THP)10 mg、배린선알(CTX)200 mg、잡박(CBP)50 mg치입청소림파결처,이급술후행흉강관주필유비성50 mg、배린선알600 mg、잡박수침300 mg、α-간우소500만U.량조균우수술후제3주채용자삼순(PTX)+THP+CBP/순박(DDP)혹길서타빈(GEM)+CBP/DDP급PTX+오사리박(L-OHP)혹이장춘화감(NVB)+L-OHP등다충방안교체정맥연합화료,4주위일료정,공4-6개료정.수방3년진행료효비교.결과 관찰조1、2、3년생존솔분별위88.4%、76.9%화46.1%,대조조의차위77.8%、44.4%화33.3%.결론 Ⅲa기비소세포폐암수술병술중치약술후흉강관주,보이조기연합정맥화료,가제고환자생활질량급생존솔.
Objective To investigate an effective approach for stage Ⅲ a non- small cell lung cancer. Methods The stage Ⅲ a non-small cell lung cancer were divided into observation group (26 cases) and control group(27 cases). The observation were set THP 10 mg, CTX 200 mg, CBP 50 mg on lymph during the operation and were given THP 50 mg, CTX 600 mg, CBP 300 mg, IFN-α thoracic infusion chemotherapy after surgery. All of two groups(53 cases)received alternate intravenous chemotherapy of PTX + THP + CBP/DDP or GEM + CBP/DDP or PTX + L-OHP or NVB + L-OHP regimens in 3weeks after surgery and repeat every 4 weeks. The patients had 4 to 6 therapeutic course. The follow-up survery was compared after the treatment between the two groups. Results 1,2,3 years survival rates were 88.4% ,76. 9% and 46.1% in the observation group as compared with 77.8% ,44.4% and 25.9% in the control grouup respectively. Conclusions Operation set chemicals in surgery and given thoracic infusion chemotherapy after surgery and combined chemotherapy is an effective way for treatment of stage Ⅲ a non -small cell lung cancer. It can improve the life quality and survival rates of the patients.