CAJ | 학술논문

目的探讨烧伤后增生性瘢痕患者不同时期血清中Ⅲ型前胶原氨基端肽(PⅢNP)浓度变化及其临床意义.方法选择2007年8月-2009年8月收治住院的烧伤后增生性瘢痕患者共74例,临床上分属增生性瘢痕各个时期,根据瘢痕增生时段分组,应用放免法检测患者血清中PⅢNP的浓度变化,并比较PⅢNP的血清含量与瘢痕增生时段之间的关系.结果烧伤后增生性瘢痕患者血清中PⅢNP含最和瘢痕增生时段关系密切,早期瘢痕增生患者血清中PⅢNP含量开始增加,随着增生性瘢痕的发展,其血清含量进一步的增加,到4～6个月的增生性瘢痕中,PⅢNP含量达到了高峰.伴随瘢痕的成熟,PⅢNP浓度又逐渐下降.结论烧伤后增生性患者血清中PⅢNP的含量可较好地反映增生性瘢痕组织中的胶原代谢活跃程度,是增生性瘢痕增生活跃程度较为敏感的标志物,可以用做临床来指导临床瘢痕治疗.
목적 탐토소상후증생성반흔환자불동시기혈청중Ⅲ형전효원안기단태(PⅢNP)농도변화급기림상의의.방법 선택2007년8월-2009년8월수치주원적소상후증생성반흔환자공74례,림상상분속증생성반흔각개시기,근거반흔증생시단분조,응용방면법검측환자혈청중PⅢNP적농도변화,병비교PⅢNP적혈청함량여반흔증생시단지간적관계.결과 소상후증생성반흔환자혈청중PⅢNP함최화반흔증생시단관계밀절,조기반흔증생환자혈청중PⅢNP함량개시증가,수착증생성반흔적발전,기혈청함량진일보적증가,도4～6개월적증생성반흔중,PⅢNP함량체도료고봉.반수반흔적성숙,PⅢNP농도우축점하강.결론 소상후증생성환자혈청중PⅢNP적함량가교호지반영증생성반흔조직중적효원대사활약정도,시증생성반흔증생활약정도교위민감적표지물,가이용주림상래지도림상반흔치료.
Objective To explore the level and the significance of amino-terminal propeptide of procollagen type Ⅲ(P Ⅲ NP)in the serum of hypertrophic scar patients at excessive stages.Methods The serum samples of 74 inpatients admmitted in Affiliated Fosham Hospital of Sun Yat-sen University from August 2007 to August 2009 suffering from long-persisting post-burn hypertrophic scar at various stages were collected.Serum samples of 12 were normal persons were also collected and used as control group.Hypertrophic scar group were divided into 4 subgroups according to the phase of scar and the serum concentrations of P Ⅲ NP were detected using the sensitive RIA method.Results The level of PⅢ NP increases gradually during the process of immature hypertrophic scar to mature scar before it peaking in 4 to 6 months scar subgroup.The concentration of PⅢ NP degreased gradually with the maturation of hypertrophic scar.Conclusions The high concentration of PⅢNP can reflect the high level of the synthesis of type Ⅲ collagen in the tissue of post-burn hypertrophic scar.The level of P Ⅲ NP is synonymous with the ongoing process of hypertrophic scar.PⅢ NP may be a satisfactory marker in discerning the growth and development of post-burn hypertrophic scar.