CAJ | 학술논문

目的探讨孟鲁司特钠辅治儿童支气管哮喘的临床疗效.方法将80例儿童支气管哮喘患儿随机分为治疗组与对照组,对照组按哮喘常规治疗,治疗组在此基础上加用孟鲁司特钠,比较两组治疗前后临床症状改善情况、急性期用药情况及肺功能等方面的变化.结果治疗12周后,治疗组临床总有效率达95.55％,优于对照组的80％,差异有显著性(P＜0.05);在减少吸人表面皮质激素的用量和急性期用药等方面治疗组亦优于对照组(P＜0.05);两组在嗜酸性细胞计数及肺功能测定方面有极显著差异(P＜0.01).结论孟鲁司特钠可作为儿童支气管哮喘GINA方案的重要辅助治疗措施,值得推广应用.
목적 탐토맹로사특납보치인동지기관효천적림상료효.방법 장80례인동지기관효천환인수궤분위치료조여대조조,대조조안효천상규치료,치료조재차기출상가용맹로사특납,비교량조치료전후림상증상개선정황、급성기용약정황급폐공능등방면적변화.결과 치료12주후,치료조림상총유효솔체95.55％,우우대조조적80％,차이유현저성(P＜0.05);재감소흡인표면피질격소적용량화급성기용약등방면치료조역우우대조조(P＜0.05);량조재기산성세포계수급폐공능측정방면유겁현저차이(P＜0.01).결론 맹로사특납가작위인동지기관효천GINA방안적중요보조치료조시,치득추엄응용.
Objective To investigate the clinical efficacy of Montelukast Sodium in adjunctive therapy of childhood bronchial asthma.Methods 80 cases of childhood bronchial asthma patients were randomly divided into experimental group(45 cases) and control group(35 cases).The control group was treated normally,while Montelukast Sodium was added in the experimental group.Afterwards,the conditions of bronchial asthma,the statistics of medicines taken in acute stage,lung function of two groups were compared.Results After 12 weeks' treatment,the clinical effective rate of the experimental group was as high as 95.55％,which was better than 80％ of the control group,the difference was significant(P＜ 0.05).The same occurred in the aspects of the reducing amount of the inhalation of Surface cortical hormone and drug use in acute stage(P＜ 0.05).In addition,the difference of the amount of the eosinophilia and estimation of lung function between experimental group and control group was significant(P＜ 0.01).Conclusions Montelukast Sodium is applicable as important adjunctive therapy of childhood bronchial asthma in GINA,which is worthy to be promoted.