CAJ | 학술논문

目的探讨重症肌无力(MG)患者血清Titin抗体及乙酰胆碱受体(AchR)抗体的检测意义.方法采用酶联免疫吸附试验(ELISA)对81例MG患者和80例对照组成员进行Titin和AchR抗体的检测.结果 Titin抗体对MG具有特异性,它在合并胸腺瘤的MG(MGT)、晚发型MG患者中有较高的阳性率(分别为80%、69.4%)和抗体水平,明显高于早发型MG患者的阳性率(25%)和抗体水平,差异均有统计学意义(P<0.05).而早发型MG患者中AchR抗体阳性率比晚发型MG患者明显增高.并且早发型MG患者的AchR抗体水平也明显高于晚发型MG和MGT患者,差异均有统计学意义(P<0.05).结论两种抗体检测为MG诊断和病因学研究提供了重要证据,联合检测可以提高MG诊断的灵敏度.
목적 탐토중증기무력(MG)환자혈청Titin항체급을선담감수체(AchR)항체적검측의의.방법 채용매련면역흡부시험(ELISA)대81례MG환자화80례대조조성원진행Titin화AchR항체적검측.결과 Titin항체대MG구유특이성,타재합병흉선류적MG(MGT)、만발형MG환자중유교고적양성솔(분별위80%、69.4%)화항체수평,명현고우조발형MG환자적양성솔(25%)화항체수평,차이균유통계학의의(P<0.05).이조발형MG환자중AchR항체양성솔비만발형MG환자명현증고.병차조발형MG환자적AchR항체수평야명현고우만발형MG화MGT환자,차이균유통계학의의(P<0.05).결론 량충항체검측위MG진단화병인학연구제공료중요증거,연합검측가이제고MG진단적령민도.
Objective To study the clinical significance of serum anti-Titin antibodies and thecorrelation between anti-Titin anbibodies and anti-acetyleholine receptor (AchR) antibodies in patientswith myasthenia gravis (MG). Methods We detected anti-Titin antibodies and anti-AchR antibodieswith enzyme linked immunosorbent assay (ELISA) in the sera from 81 cases of MG groups includingearly-onset MG, late-onset MG and MG with thymoma (MGT). The positive rates were compared amongthese groups. Results The positive rates of anti-Titin antibodies in sera of MG patients weresignificantly higher than controls (P<0.01). The mean titers and the positive rates of anti-Titin antibodieswere significantly higher in MGT (80%) and late-onset MG (69.4%) subgroups than in the early-onsetMG subgroup (25%). In contrast, the positive rates and mean titers of AchR antibodies in the early-onsetMG subgroup were higher than those in the late-onset MG subgroup. The detections of serum anti-Titinantibodies and AchR antibodies were consistent with the diagnosis of MG. Conclusion Anti-Titinantibodies are specific for MG. They often present in the sera of patients with MGT and late-onset MG.The positive rates and mean titers of AchR antibodies in early-onset MG patients sera are higher thanthose in late-onset MG patients. These features prompt fiu'ther studies on the pathogenesis of MG. Testingfor a combination of anti-Titin antibodies and AchR antibodies gives the higher sensitivity for thedetection of MG than each antibody alone.