中华神经医学杂志
中華神經醫學雜誌
중화신경의학잡지
CHINESE JOURNAL OF NEUROMEDICINE
2011年
11期
1168-1171
,共4页
林彬%钱若兵%傅先明%季学兵%魏祥品%胡文富%伊涛%王昌新%牛朝诗%汪业汉
林彬%錢若兵%傅先明%季學兵%魏祥品%鬍文富%伊濤%王昌新%牛朝詩%汪業漢
림빈%전약병%부선명%계학병%위상품%호문부%이도%왕창신%우조시%왕업한
海洛因成瘾%冲动行为%风险决策%前额叶
海洛因成癮%遲動行為%風險決策%前額葉
해락인성은%충동행위%풍험결책%전액협
Heroin addiction%Impulsiveness%Risk-taking decision-making%Prefrontal cortex
目的 探讨海洛因成瘾者冲动行为与风险决策的反应模式及其意义.方法 选择自2010年7月至12月在安徽省戒毒康复中心自愿接受戒毒的海洛因成瘾者17例作为海洛因成瘾组(HA组),同期招募的志愿者18例作为健康对照组(HC组).2组被试分别执行爱荷华赌博任务(IGT)和风险决策任务(RGT),分析比较2组被试冲动行为控制和风险决策能力的差异.结果 IGT中,决策进程对HA组的净分数无明显影响,但对HC组有明显影响(P＜0.05); HA组所选低频惩罚的纸牌数目与高频惩罚纸牌相比差异无统计学意义(P＞0.05),但HC组二者数目差异有统计学意义(P＜0.05)；被试选择低频惩罚与高频惩罚的纸牌数目差值在2组之间差异有统计学意义(P＜0.05).RGT中,HC组经历惩罚后风险选择频率明显下降,与经历惩罚前比较差异有统计学意义(P＜0.05),HA组却无明显下降(P＞0.05); HA组在奖赏后和惩罚后的风险选择频率均明显高于HC组,差异有统计学意义(P＜0.05).结论 作为长期海洛因成瘾行为的表现,海洛因成瘾者存在冲动行为和风险决策障碍,这可能是成瘾行为产生和维持的原因之一.
目的 探討海洛因成癮者遲動行為與風險決策的反應模式及其意義.方法 選擇自2010年7月至12月在安徽省戒毒康複中心自願接受戒毒的海洛因成癮者17例作為海洛因成癮組(HA組),同期招募的誌願者18例作為健康對照組(HC組).2組被試分彆執行愛荷華賭博任務(IGT)和風險決策任務(RGT),分析比較2組被試遲動行為控製和風險決策能力的差異.結果 IGT中,決策進程對HA組的淨分數無明顯影響,但對HC組有明顯影響(P＜0.05); HA組所選低頻懲罰的紙牌數目與高頻懲罰紙牌相比差異無統計學意義(P＞0.05),但HC組二者數目差異有統計學意義(P＜0.05)；被試選擇低頻懲罰與高頻懲罰的紙牌數目差值在2組之間差異有統計學意義(P＜0.05).RGT中,HC組經歷懲罰後風險選擇頻率明顯下降,與經歷懲罰前比較差異有統計學意義(P＜0.05),HA組卻無明顯下降(P＞0.05); HA組在獎賞後和懲罰後的風險選擇頻率均明顯高于HC組,差異有統計學意義(P＜0.05).結論 作為長期海洛因成癮行為的錶現,海洛因成癮者存在遲動行為和風險決策障礙,這可能是成癮行為產生和維持的原因之一.
목적 탐토해락인성은자충동행위여풍험결책적반응모식급기의의.방법 선택자2010년7월지12월재안휘성계독강복중심자원접수계독적해락인성은자17례작위해락인성은조(HA조),동기초모적지원자18례작위건강대조조(HC조).2조피시분별집행애하화도박임무(IGT)화풍험결책임무(RGT),분석비교2조피시충동행위공제화풍험결책능력적차이.결과 IGT중,결책진정대HA조적정분수무명현영향,단대HC조유명현영향(P＜0.05); HA조소선저빈징벌적지패수목여고빈징벌지패상비차이무통계학의의(P＞0.05),단HC조이자수목차이유통계학의의(P＜0.05)；피시선택저빈징벌여고빈징벌적지패수목차치재2조지간차이유통계학의의(P＜0.05).RGT중,HC조경력징벌후풍험선택빈솔명현하강,여경력징벌전비교차이유통계학의의(P＜0.05),HA조각무명현하강(P＞0.05); HA조재장상후화징벌후적풍험선택빈솔균명현고우HC조,차이유통계학의의(P＜0.05).결론 작위장기해락인성은행위적표현,해락인성은자존재충동행위화풍험결책장애,저가능시성은행위산생화유지적원인지일.
Objective To explore the reaction patterns of impulsiveness and risk-taking decision-making in heroin addicts and their significance.Methods Seventeen heroin addicts(HA group)admitted to Detoxification and Rehabilitation Center of Anhui Province from July 2010 to December 2010 and 18 healthy controls(HC group)recruited at the same period were performed Iowa gambling task(IGT)and Risky-Gains task(RGT),respectively; the different capacities of impulsiveness control and risk-taking decision-making between HA group and HC group were compared.Results As for IGT,decision-making course affected the net scores remarkably in HC group,whereas contrary result was observed in HA group(P＜0.05); no statistical difference between the numbers of low-frequency punishment cards and high-frequency punishment cards which subjects selected was noted in HA group,while statistical difference was observed in HC group(P＜0.05).Furthermore,the difference between the number of low-frequency punishment cards and high-frequency punishment cards in HC group was higher than that in HA group(P＜0.05).In RGT,as compared with risky response rate before punishment,risky response rate after punishment declined notably in HC group,while no significant changes were seen in HA group; risky response rate after reward and after punishment in HA group were significantly higher than those in HC group(P＜0.05).Conclusion As evidence of chronic heroin addicts' behavior,heroin addict exsits impulsiveness and deficit in risk-taking decision-making,which may be one of the causes of generation and maintenance of heroin addiction.
