CAJ | 학술논문

目的探讨胆碱、甲硫氨酸、脱氧胸腺嘧啶核苷、乙酸盐为示踪剂的正电子发射体层显像(PET)在肺部病变诊断中的应用价值.方法 2002年6月至2007年6月对100例肺部占位病变的患者行PET检查.其中~(11)C-胆碱(CH)-PET检查58例,~(11)C-甲硫氨酸(MET)-PET检查16例,~(18)F-脱氧胸腺嘧啶核苷(FLT)-PET检查22例,~(11)C-乙酸盐(AC)-PET检查4例.结果采用目测法判读,半定量分析法测量病变标准摄取值,结果与病理诊断及随访结果对照.结果CH-PET定性诊断灵敏度、特异度、符合率分别为84.2%(32/38)、57.9%(11/19)、75.4%(43/57).MET-PET定性诊断灵敏度、特异度、符合率分别为6/7、6/9、75.0%(12/16).FLT-PET检查定性诊断灵敏度、特异度、符合率分别为85.7%(12/14)、2/8、63.6%(14/22).CH.PET、MET-PET及FLT-PET中肿瘤标准摄取值与肿瘤大小、患者年龄不相关.AC.PET检查仅1例透明细胞癌肺转移显影,2例鳞状细胞癌、1例腺癌没有显影.结论这些示踪剂PET对肺部病变的定性诊断有帮助,但存在假阳性和假阴性结果.
목적 탐토담감、갑류안산、탈양흉선밀정핵감、을산염위시종제적정전자발사체층현상(PET)재폐부병변진단중적응용개치.방법 2002년6월지2007년6월대100례폐부점위병변적환자행PET검사.기중~(11)C-담감(CH)-PET검사58례,~(11)C-갑류안산(MET)-PET검사16례,~(18)F-탈양흉선밀정핵감(FLT)-PET검사22례,~(11)C-을산염(AC)-PET검사4례.결과 채용목측법판독,반정량분석법측량병변표준섭취치,결과여병리진단급수방결과대조.결과CH-PET정성진단령민도、특이도、부합솔분별위84.2%(32/38)、57.9%(11/19)、75.4%(43/57).MET-PET정성진단령민도、특이도、부합솔분별위6/7、6/9、75.0%(12/16).FLT-PET검사정성진단령민도、특이도、부합솔분별위85.7%(12/14)、2/8、63.6%(14/22).CH.PET、MET-PET급FLT-PET중종류표준섭취치여종류대소、환자년령불상관.AC.PET검사부1례투명세포암폐전이현영,2례린상세포암、1례선암몰유현영.결론 저사시종제PET대폐부병변적정성진단유방조,단존재가양성화가음성결과.
Objective To assess the value of positron emission tomography (PET) with ~(11)C-choline(CH), ~(11)C-methionine ( MET),~(18)F-fluorothymidine ( FLT), and ~(11)C-acetate (AC) in diagnosis of pulmonary abnormalities and the features of pulmonary abnormalities in PET. Methods From June 2002 to June 2007, 100 patients with pulmonary nodules or masses confirmed by CT scans received PET with special tracers. Fifty-eight patients received CH-PET, 16 patients received MET-PET, 22 patients received FLT-PET, 4 patients received AC-PET. PET data was analyzed by visual method and semiquantitative method with standard uptake value (SUV). Diagnoses were compared with pathology and follow-up survey. Results For identification of pulmonary neoplasms with CH-PET, the sensitivity, specificity and accuracy were 84. 2% (32/38), 57. 9% (11/19) and 75.4% (43/57). In cancer cases, SUV had no correlation with tumor size or age. For identification of pulmonary neoplasms with MET-PET, the sensitivity, specificity and accuracy were 6/7, 6/9 and 75.0% (12/16). In cancer cases, SUV had not correlation with tumor size orage. For identification of pulmonary neoplasms with FLT-PET, the sensitivity, specificity and accuracy were 85.7% (12/14), 2/8 and 63.6% (14/22). In cancer cases, SUV had not correlation with tumor size or age. In AC-PET, only 1 case of pulmonary metastasis of kidney clear cell carcinoma showed acetate avid.Two squamous cell carcinoma and 1 adenocarcinoma didn't appear abnormal in AC-PET. Conclusion CH,MET, FLT, AC are valuable in diagnosing but also lead to false positive and false negative.