肿瘤研究与临床
腫瘤研究與臨床
종류연구여림상
CANCER RESEARCH AND CLINIC
2007年
z1期
51-52
,共2页
食管肿瘤%放射疗法%药物疗法
食管腫瘤%放射療法%藥物療法
식관종류%방사요법%약물요법
Esophageal neoplasms%Radio therapy%Drug therapy
目的 观察对中晚期食管癌患者同步放化疗,疗效及毒副作用.方法 中晚期食管癌120例,随机分放化疗组60例(简称放化组)和单纯放疗组60例(简称单放组).放疗采用常规分割,DT40 Gy后缩小照射野,避开脊髓斜野照射,加量DT20～30 Gy,6～7周完成.放化组放疗1、4周后应用顺铂(DDP)20 mg/d、亚叶酸钙(CF)0.1 g/d,CF静脉滴注1/2量时5-氟尿嘧啶(5-Fu)500 mg/d静脉滴注,连续5 d为1个周期,化疗当天进行放疗.结果 放化组与单放组1、2、3年生存率分别为67%、46%、34%和52%、38%、24%;放射性肺炎分别为14例和12例;外周血细胞下降分别为26例和17例;胃肠道反应分别为25例和9例;死亡分别为38例和48例.两组治疗效果比较差异有统计学意义(P＜0.05).结论 放疗同步PLF方案化疗治疗中晚期食管癌生存率高,毒副作用及不良反应低.
目的 觀察對中晚期食管癌患者同步放化療,療效及毒副作用.方法 中晚期食管癌120例,隨機分放化療組60例(簡稱放化組)和單純放療組60例(簡稱單放組).放療採用常規分割,DT40 Gy後縮小照射野,避開脊髓斜野照射,加量DT20～30 Gy,6～7週完成.放化組放療1、4週後應用順鉑(DDP)20 mg/d、亞葉痠鈣(CF)0.1 g/d,CF靜脈滴註1/2量時5-氟尿嘧啶(5-Fu)500 mg/d靜脈滴註,連續5 d為1箇週期,化療噹天進行放療.結果 放化組與單放組1、2、3年生存率分彆為67%、46%、34%和52%、38%、24%;放射性肺炎分彆為14例和12例;外週血細胞下降分彆為26例和17例;胃腸道反應分彆為25例和9例;死亡分彆為38例和48例.兩組治療效果比較差異有統計學意義(P＜0.05).結論 放療同步PLF方案化療治療中晚期食管癌生存率高,毒副作用及不良反應低.
목적 관찰대중만기식관암환자동보방화료,료효급독부작용.방법 중만기식관암120례,수궤분방화료조60례(간칭방화조)화단순방료조60례(간칭단방조).방료채용상규분할,DT40 Gy후축소조사야,피개척수사야조사,가량DT20～30 Gy,6～7주완성.방화조방료1、4주후응용순박(DDP)20 mg/d、아협산개(CF)0.1 g/d,CF정맥적주1/2량시5-불뇨밀정(5-Fu)500 mg/d정맥적주,련속5 d위1개주기,화료당천진행방료.결과 방화조여단방조1、2、3년생존솔분별위67%、46%、34%화52%、38%、24%;방사성폐염분별위14례화12례;외주혈세포하강분별위26례화17례;위장도반응분별위25례화9례;사망분별위38례화48례.량조치료효과비교차이유통계학의의(P＜0.05).결론 방료동보PLF방안화료치료중만기식관암생존솔고,독부작용급불량반응저.
Objective To patient who suffer from middle and late period carcinoma of esophagus radiation therapy and chemotherapy. Observe the effects and the side effects of radiation therapy and chemotherapy.Methods Radiation therapy and chemotherapy 60 examples and radiation therapy 60 examples,radiation use usually divide,DT 40 Gy reduce area of radiation therapy,aroid medulla,add DT 20～30 Gy,its finished after 6～7 weeks.radiation therapy and chemotherapy after 1 and 4 week,DDP 20 mg/d is used.CF 0.1/d ivgtt CF ivgtt 1/2 is used use 5-fu 500 mg/d.iv five days in a routine,every day use radiation therapy and chemotherapy.Results Radiation therapy and chemotherapy 1,2,3 year alive rate are 67%,46%,34%,radiation therapy 1,2,3 year alive rate are 52%,38%,24%,pneumonia of radiation therapy is 14 examples and 12 examples,leukocyte in blood reaction is 26 examples and 17 examples,gastrointestinal effective is 25examples and 9 examples,death is 38 examples and 48 examples,treatment routine is better than compare routine (P＜0.05).Conclusion Radiation with PCF plan chemotherapy treat middle and late period carcinoma of esophagus have hish alive rate side effects and bad effects are low.
