CAJ | 학술논문

目的研究吲达帕胺对雌性和雄性大鼠替米沙坦药代动力学的影响.方法 Wistar大鼠随机分为替米沙坦单用和替米沙坦与吲哒帕胺联用组,雌雄各半,分别单次ig给予替米沙坦3.6 mg·kg-1或替米沙坦3.6 mg·kg-1+吲达帕胺0.135 mg·kg-1.96 h内定时取血后,采用反相高效液相色谱-荧光检测法测定血浆中替米沙坦浓度.结果无论雄性雌性大鼠,与替米沙坦单用组相比,联用吲达帕胺后替米沙坦的主要药代动力学参数无显著性改变;而不同性别大鼠替米沙坦的药代动力学有显著差异,无论替米沙坦单用或联用吲达帕胺组,雌性大鼠替米沙坦的主要药代动力学参数AUC和cmax值均显著高于雄性,而血浆清除率显著低于雄性.结论替米沙坦与吲达帕胺联用对大鼠替米沙坦的药代动力学无明显影响; 而无论替米沙坦单用或联用吲达帕胺,雌性和雄性大鼠替米沙坦的药代动力学存在显著的性别差异.
목적 연구신체파알대자성화웅성대서체미사탄약대동역학적영향.방법 Wistar대서수궤분위체미사탄단용화체미사탄여신달파알련용조,자웅각반,분별단차ig급여체미사탄3.6 mg·kg-1혹체미사탄3.6 mg·kg-1+신체파알0.135 mg·kg-1.96 h내정시취혈후,채용반상고효액상색보-형광검측법측정혈장중체미사탄농도.결과 무론웅성자성대서,여체미사탄단용조상비,련용신체파알후체미사탄적주요약대동역학삼수무현저성개변;이불동성별대서체미사탄적약대동역학유현저차이,무론체미사탄단용혹련용신체파알조,자성대서체미사탄적주요약대동역학삼수AUC화cmax치균현저고우웅성,이혈장청제솔현저저우웅성.결론 체미사탄여신체파알련용대대서체미사탄적약대동역학무명현영향; 이무론체미사탄단용혹련용신체파알,자성화웅성대서체미사탄적약대동역학존재현저적성별차이.
AIM To study the influence of indapamide(Ind) on pharmacokinetics of telmisartan(Tel) and observe the difference between male and female rats. METHODS Wistar rats were divided into Tel and Tel+Ind groups, each group containing 8 female and 8 male rats, and were ig administered a single dose of either Tel 3.6 mg·kg-1 or Tel 3.6 mg·kg-1+Ind 0.135 mg·kg-1, respectively. Blood samples were collected at intervals over 96 h after administration. The Tel concentrations in plasma were determined by high performance liquid chromatography with fluorescence detector. The Tel concentration-time curves were simulated by 3p97 software and the pharmacokinetic parameters were calculated. RESULTS Whatever in female or male rats, there were no significant differences in the main pharmacokinetic parameters of Tel between Tel and Tel+Ind groups. However, females had higher values for area under the concentration-time curve and maximum plasma concentration than males, but lower values for total clearance in both Tel and Tel+Ind groups. CONCLUSION Ind has no significant influences on the pharmacokinetics of Tel. However, pharmacokinetics of Tel is significant different between male and female rats.