中国医师杂志
中國醫師雜誌
중국의사잡지
JOURNAL OF CHINESE PHYSICIAN
2011年
2期
167-169
,共3页
张克莹%曹鹏%都健%于轶楠%李赟%罗红飞
張剋瑩%曹鵬%都健%于軼楠%李赟%囉紅飛
장극형%조붕%도건%우질남%리빈%라홍비
糖尿病,2型/代谢%血红蛋白A,糖基化/代谢%白蛋白类/代谢%脂类代谢%肝/酶学
糖尿病,2型/代謝%血紅蛋白A,糖基化/代謝%白蛋白類/代謝%脂類代謝%肝/酶學
당뇨병,2형/대사%혈홍단백A,당기화/대사%백단백류/대사%지류대사%간/매학
Diabetes mellitus,type 2/ME%Hemoglobin A,glycosylated/ME%Albumins/ME%Lipid metabolism%Liver/EN
目的 探讨2型糖尿病患者HbA1c是否达标对尿蛋白、血脂及肝酶的影响.方法 采用多阶段分层整群抽样方法 回顾性分析457例已确诊2型糖尿病患者的资料,根据HbA1c结果 判定分为未达标组与达标组,采集患者一般资料及实验室相关指标等进行比较.结果 两组患者的尿微量白蛋白、血清甘油三酯及肝酶学指标(谷氨酰转肽酶、碱性磷酸酶、谷草转氨酶)结果 差异有统计学意义[(189.8±235.3)mg/dl vs(38.9±85.5)mg/dl、(2.64±2.99)mmol/L vs(2.02±1.50)mmol/L、(41.7±52.9)U/L vs(29.7±24.9)U/L、(83.6±28.6)U/L vs(74.3±25.8)U/L、(26.7±19.1)U/L vs(22.0±10.5)U/L,P＜0.05].HbA1c与尿微量白蛋白、谷氨酰转肽酶、碱性磷酸酶呈正相关(r=0.209、0.115、0.11,P＜0.01).尿微量白蛋白是影响2型糖尿病患者HbA1c达标的独立危险因素(OR=1.009,P＜0.05).结论 HbA1c达标与否对血糖外多种因素均有影响.
目的 探討2型糖尿病患者HbA1c是否達標對尿蛋白、血脂及肝酶的影響.方法 採用多階段分層整群抽樣方法 迴顧性分析457例已確診2型糖尿病患者的資料,根據HbA1c結果 判定分為未達標組與達標組,採集患者一般資料及實驗室相關指標等進行比較.結果 兩組患者的尿微量白蛋白、血清甘油三酯及肝酶學指標(穀氨酰轉肽酶、堿性燐痠酶、穀草轉氨酶)結果 差異有統計學意義[(189.8±235.3)mg/dl vs(38.9±85.5)mg/dl、(2.64±2.99)mmol/L vs(2.02±1.50)mmol/L、(41.7±52.9)U/L vs(29.7±24.9)U/L、(83.6±28.6)U/L vs(74.3±25.8)U/L、(26.7±19.1)U/L vs(22.0±10.5)U/L,P＜0.05].HbA1c與尿微量白蛋白、穀氨酰轉肽酶、堿性燐痠酶呈正相關(r=0.209、0.115、0.11,P＜0.01).尿微量白蛋白是影響2型糖尿病患者HbA1c達標的獨立危險因素(OR=1.009,P＜0.05).結論 HbA1c達標與否對血糖外多種因素均有影響.
목적 탐토2형당뇨병환자HbA1c시부체표대뇨단백、혈지급간매적영향.방법 채용다계단분층정군추양방법 회고성분석457례이학진2형당뇨병환자적자료,근거HbA1c결과 판정분위미체표조여체표조,채집환자일반자료급실험실상관지표등진행비교.결과 량조환자적뇨미량백단백、혈청감유삼지급간매학지표(곡안선전태매、감성린산매、곡초전안매)결과 차이유통계학의의[(189.8±235.3)mg/dl vs(38.9±85.5)mg/dl、(2.64±2.99)mmol/L vs(2.02±1.50)mmol/L、(41.7±52.9)U/L vs(29.7±24.9)U/L、(83.6±28.6)U/L vs(74.3±25.8)U/L、(26.7±19.1)U/L vs(22.0±10.5)U/L,P＜0.05].HbA1c여뇨미량백단백、곡안선전태매、감성린산매정정상관(r=0.209、0.115、0.11,P＜0.01).뇨미량백단백시영향2형당뇨병환자HbA1c체표적독립위험인소(OR=1.009,P＜0.05).결론 HbA1c체표여부대혈당외다충인소균유영향.
Objective To investigate the effect of HbA1c meeting the standard or not on microalbuminuria,blood lipids and liver enzymes in patients with type 2 diabetes.Methods A retrospective analysis was performed on 457 subjects who had type 2 diabetes.They were divided into substandard group and standard group according to HbA1c result.The general information and relevant laboratory indicators of patients were.collected and compared between two groups.Results The microalbuminuria,serum triglyceride and liver enzymes (glutamyl transpeptidase,alkaline phosphatase,aspertate aminotransferase) were significantly different between two groups [ (189.8 ± 235.3) mg/dl vs (38.9 ± 85.5) mg/dl,(2.64 ± 2.99) mmol/L vs (2.02 ± 1.50)mmol/L,(41.7 ±52.9)U/L vs (29.7 ±24.9)U/L,(83.6 ±28.6) U/L vs (74.3 ±25.8)U/L,(26.7 ±19.1)U/L vs (22.0 ±10.5) U/L,P ＜0.05].HbA1c level was positively correlated with microalbuminuria,glutamyl transpeptidase and alkaline phosphatase (r =0.209,0.115,0.11,P ＜0.01).The microalbuminuria was an independent risk factor of affecting HbA1c to reach the standard (OR = 1.009,P ＜0.05).Conclusions HbA1c meeting the standard or not can influence many factors except blood glucose.
