CAJ | 학술논문

为观察雷公藤有效成份之一雷公藤红素单体对犬异体肾移植抗排斥的疗效,制作标准的犬异体肾移植模型.术后受体随机分成6组:1个对照组,5个治疗组,雷公藤红素的用量分别为0.05rag·kg-1/d、0.1mg·kg-1/d、0.5mg·kg-1/d、1.Omg·kg-1/d和0.2mg·kg-1/d.结果各治疗组受体的存活期与对照组相似,绝大多数犬在术后第8～12天死亡,仅0.1mg·kg-1/d组有1只犬存活29天.认为雷公藤红素对杂种狗间的异体肾移植的排斥无抑制作用.
위관찰뢰공등유효성빈지일뢰공등홍소단체대견이체신이식항배척적료효,제작표준적견이체신이식모형.술후수체수궤분성6조:1개대조조,5개치료조,뢰공등홍소적용량분별위0.05rag·kg-1/d、0.1mg·kg-1/d、0.5mg·kg-1/d、1.Omg·kg-1/d화0.2mg·kg-1/d.결과각치료조수체적존활기여대조조상사,절대다수견재술후제8～12천사망,부0.1mg·kg-1/d조유1지견존활29천.인위뢰공등홍소대잡충구간적이체신이식적배척무억제작용.
The immunosuppresive effect of Tripterine monomer on renal transplant mongerl dogs was studied.The recipient dogs with standard renal allografts were divided into six groups:The control group and the experimental group I～V treated by Tripterine in the doses of 0.05,the experimental groups was found.Most of the recipients died within 8～12 days postoperately,only one dog in groupⅡ(0.1 mg/kg)survived as long as 20 days.The resultes showed that Tripterine has no significant immunosuppressive effect on renal transplant mongrel dogs.