中国药物依赖性杂志
中國藥物依賴性雜誌
중국약물의뢰성잡지
CHINESE JOURNAL OF DRUG DEPENDENCE
2009年
6期
474-477
,共4页
张尧%徐再锋%张昌勇%田艳%汤珺
張堯%徐再鋒%張昌勇%田豔%湯珺
장요%서재봉%장창용%전염%탕군
苯丙胺类相关性障碍%事件相关电位P_(300)%行为症状%精神病性症状
苯丙胺類相關性障礙%事件相關電位P_(300)%行為癥狀%精神病性癥狀
분병알류상관성장애%사건상관전위P_(300)%행위증상%정신병성증상
amphetamine-related disorders%event-related potential P_(300)%behavioral symptoms%psychiatric symptom
目的:探讨苯丙胺类中枢兴奋剂(ATS)依赖者事件相关电位P_(300)主要指标的变化特点及其与临床精神症状的相互关系.方法:对40例ATS依赖病例(研究组)和30例本院职工或家属(对照组)进行事件相关电位P_(300)的检测,并使用症状自评量表对研究组进行评定.结果:ATS依赖者靶刺激N_2潜伏期(245.74 ms±s 12.60 ms)、P_3潜伏期(318.46 ms±s 18.77 ms)、P_2-N_2峰间潜伏期(69.13 ms±s 10.76 ms)较正常对照组(238.81 ms±s 13.70 ms,310.27 ms±s 11.41 ms,65.23 ms±s 11.58 ms)延长,均P<0.05,P_3波幅(5.31 ms±s 2.39 ms)低于正常对照组(9.50 ms±s 1.58 ms),P<0.01;伴有精神病性症状的ATS依赖者P_3波幅(4.64 uv±s 2.96 uv)低于不伴有精神病性症状的依赖者波幅(5.73 uv±s 3.66 uv),P_3潜伏期(320.36 ms±s 19.23 ms)较不伴有精神病性症状的依赖者(312.73 ms±s 18.19 ms)延长,P<0.05;N_2潜伏期与焦虑分(r=-0.366)、偏执分呈负相关(r=-0.386);P_3潜伏期与精神病性症状分(r=-0.430)、躯体化分呈负相关(r=-0.397);P_3波幅与精神病性症状分呈负相关(r=-0.486).结论:ATS依赖者存在明显的认知功能损害,其中N_2潜伏期、P_3潜伏期及P_3波幅与ATS依赖者的多种临床症状呈相关性.
目的:探討苯丙胺類中樞興奮劑(ATS)依賴者事件相關電位P_(300)主要指標的變化特點及其與臨床精神癥狀的相互關繫.方法:對40例ATS依賴病例(研究組)和30例本院職工或傢屬(對照組)進行事件相關電位P_(300)的檢測,併使用癥狀自評量錶對研究組進行評定.結果:ATS依賴者靶刺激N_2潛伏期(245.74 ms±s 12.60 ms)、P_3潛伏期(318.46 ms±s 18.77 ms)、P_2-N_2峰間潛伏期(69.13 ms±s 10.76 ms)較正常對照組(238.81 ms±s 13.70 ms,310.27 ms±s 11.41 ms,65.23 ms±s 11.58 ms)延長,均P<0.05,P_3波幅(5.31 ms±s 2.39 ms)低于正常對照組(9.50 ms±s 1.58 ms),P<0.01;伴有精神病性癥狀的ATS依賴者P_3波幅(4.64 uv±s 2.96 uv)低于不伴有精神病性癥狀的依賴者波幅(5.73 uv±s 3.66 uv),P_3潛伏期(320.36 ms±s 19.23 ms)較不伴有精神病性癥狀的依賴者(312.73 ms±s 18.19 ms)延長,P<0.05;N_2潛伏期與焦慮分(r=-0.366)、偏執分呈負相關(r=-0.386);P_3潛伏期與精神病性癥狀分(r=-0.430)、軀體化分呈負相關(r=-0.397);P_3波幅與精神病性癥狀分呈負相關(r=-0.486).結論:ATS依賴者存在明顯的認知功能損害,其中N_2潛伏期、P_3潛伏期及P_3波幅與ATS依賴者的多種臨床癥狀呈相關性.
목적:탐토분병알류중추흥강제(ATS)의뢰자사건상관전위P_(300)주요지표적변화특점급기여림상정신증상적상호관계.방법:대40례ATS의뢰병례(연구조)화30례본원직공혹가속(대조조)진행사건상관전위P_(300)적검측,병사용증상자평량표대연구조진행평정.결과:ATS의뢰자파자격N_2잠복기(245.74 ms±s 12.60 ms)、P_3잠복기(318.46 ms±s 18.77 ms)、P_2-N_2봉간잠복기(69.13 ms±s 10.76 ms)교정상대조조(238.81 ms±s 13.70 ms,310.27 ms±s 11.41 ms,65.23 ms±s 11.58 ms)연장,균P<0.05,P_3파폭(5.31 ms±s 2.39 ms)저우정상대조조(9.50 ms±s 1.58 ms),P<0.01;반유정신병성증상적ATS의뢰자P_3파폭(4.64 uv±s 2.96 uv)저우불반유정신병성증상적의뢰자파폭(5.73 uv±s 3.66 uv),P_3잠복기(320.36 ms±s 19.23 ms)교불반유정신병성증상적의뢰자(312.73 ms±s 18.19 ms)연장,P<0.05;N_2잠복기여초필분(r=-0.366)、편집분정부상관(r=-0.386);P_3잠복기여정신병성증상분(r=-0.430)、구체화분정부상관(r=-0.397);P_3파폭여정신병성증상분정부상관(r=-0.486).결론:ATS의뢰자존재명현적인지공능손해,기중N_2잠복기、P_3잠복기급P_3파폭여ATS의뢰자적다충림상증상정상관성.
Objective:To explore the variability feature of P_(300),and the correlation between P_(300) and clinical manifestation in patients with amphetamine type stimulants(ATS)dependence.Methods:Forty ATS dependent patients and 30 normal controls were assessed by auditory event-related potential P_(300) with Galileo Sirius 32 channels digital evoked potential systems and SCL-90.Results:In comparison with normal controls(N_2 238.81±s 13.70 ms,P_3 310.27 ms±s 11.41 ms,P_2-N_2(65.23 ms±s 11.58 ms,P_3 9.5 0 ms±s 1.58 ms),ATS dependent patients had longer latency of N_2(245.74 ms±s 12.60 ms),P_3(318.46 ms±s 18.77 ms)and inter-peak latency of P_2-N_2(69.13 ms±s 10.76 ms),P<0.05,and lower amplitude of P_3(5.31 ms±s 2.39 ms),P<0.01.ATS dependent patients with psychotic symptoms had lower amplitude of P_3(4.64 uv±s 2.96 uv)and longer latency of P_3(320.36 ms±s 19.23 ms) than those without psychotic symptoms(5.73 uv±s 3.66 uv,312.73 ms±s 18.19 ms),P<0.05; latency of N_2 was inversely correlated to anxiety(r=-0.366)and paranoia(r=-0.386);latency of P_3 was inversely correlated to psychiatric symptoms(r=-0.430),somatization(r=-0.397),amplitude of P_3 was inversely correlated to psychiatric symptom(r=-0.486).Conclusion:ATS dependent patients suffer from cognitive dysfunction.Latency of N_2,P_3 and amplitude of P_3 have different correlations with many psychotic symptoms.
