中华内分泌外科杂志
中華內分泌外科雜誌
중화내분비외과잡지
CHINESE JOURNAL OF ENDOCRINE SURGERY
2010年
2期
73-75
,共3页
蔚青%金晓龙%叶蕾%朱延波%吴华成%崔斌%王卫庆%杨小妹%王华枫%高亚博%肖家诚
蔚青%金曉龍%葉蕾%硃延波%吳華成%崔斌%王衛慶%楊小妹%王華楓%高亞博%肖傢誠
위청%금효룡%협뢰%주연파%오화성%최빈%왕위경%양소매%왕화풍%고아박%초가성
甲状腺%白介素13%趋化因子受体
甲狀腺%白介素13%趨化因子受體
갑상선%백개소13%추화인자수체
Thyroid%IL-13%CXCR4
目的 通过检测白介素13(IL-13)和趋化因子受体(CXCR4)在甲状腺乳头状癌(PTC)和结节性甲状腺肿(NG)中的表达,研究诊断PTC的辅助指标,并阐明两者关系.方法 选取2007年至2008年上海交通大学医学院附属瑞金医院临床和病理资料完整的甲状腺手术标本160例(其中PTC 80例,NG80例).采用免疫组织化学技术,检测PTC及NG中IL-13和CXCR4的表达情况.结果 IL-13在PTC中表达率为93.75%,明显高于NG组的表达(8.75%),两组间差异有统计学意义(P<0.05).CXCR4在PTC中表达率为82.50%,明显高于NG组的表达(15.00%),两组间差异有统计学意义(P<0.05).在PTC中,IL-13和CXCR4的表达呈正相关(P<0.05).结论 IL-13和CXCR4可做为PTC的预判指标,其高表达提示甲状腺结节恶性倾向.
目的 通過檢測白介素13(IL-13)和趨化因子受體(CXCR4)在甲狀腺乳頭狀癌(PTC)和結節性甲狀腺腫(NG)中的錶達,研究診斷PTC的輔助指標,併闡明兩者關繫.方法 選取2007年至2008年上海交通大學醫學院附屬瑞金醫院臨床和病理資料完整的甲狀腺手術標本160例(其中PTC 80例,NG80例).採用免疫組織化學技術,檢測PTC及NG中IL-13和CXCR4的錶達情況.結果 IL-13在PTC中錶達率為93.75%,明顯高于NG組的錶達(8.75%),兩組間差異有統計學意義(P<0.05).CXCR4在PTC中錶達率為82.50%,明顯高于NG組的錶達(15.00%),兩組間差異有統計學意義(P<0.05).在PTC中,IL-13和CXCR4的錶達呈正相關(P<0.05).結論 IL-13和CXCR4可做為PTC的預判指標,其高錶達提示甲狀腺結節噁性傾嚮.
목적 통과검측백개소13(IL-13)화추화인자수체(CXCR4)재갑상선유두상암(PTC)화결절성갑상선종(NG)중적표체,연구진단PTC적보조지표,병천명량자관계.방법 선취2007년지2008년상해교통대학의학원부속서금의원림상화병리자료완정적갑상선수술표본160례(기중PTC 80례,NG80례).채용면역조직화학기술,검측PTC급NG중IL-13화CXCR4적표체정황.결과 IL-13재PTC중표체솔위93.75%,명현고우NG조적표체(8.75%),량조간차이유통계학의의(P<0.05).CXCR4재PTC중표체솔위82.50%,명현고우NG조적표체(15.00%),량조간차이유통계학의의(P<0.05).재PTC중,IL-13화CXCR4적표체정정상관(P<0.05).결론 IL-13화CXCR4가주위PTC적예판지표,기고표체제시갑상선결절악성경향.
Objective To detect the expression of interleukin 13(IL-13)and chemokine receptor(CXCR4)in papillary thyroid carcinoma.(PTC)and nodular goiter(NG)for screening the useful biomarkers to help the diagnosis of PTC and to investigate the relationship between the expression of IL-13 and CXCR4 in PTC.Methods 160 surgical specimens,including 80 PTC and 80 NG,Were collected in Ruijin hospital affiliated to Shanghai Jiantong university school of medicine during the period of 2007 to 2008.The clinicopathological data of all cases were also collected.The expression of IL-13 and CXCR4 in all 160 samples was detected by immanohistochemical staining.Results IL-13 expression in PTC was significantly higher than in NG(93.75% vs8.75%).There was statistically significant difference between samples of PTC and NG(P<0.05).CXCR4 expression was significantly higher in PTC than in NG(82.50%vs 15.00%).There was statistically significant difference between PTC and NG(P<0.05).Positive correlation was revealed between IL-13 and CXCR4 expression in PTC samples.Conclusions IL-13 and CXCR4 can be used as the biomarkers for PTC.The high expression of the two markers is commonly associated with malignant behavior.
