中国行为医学科学
中國行為醫學科學
중국행위의학과학
2008年
3期
227-228
,共2页
董存岩%皮兰敢%唐爱国%罗昔波%敖翔
董存巖%皮蘭敢%唐愛國%囉昔波%敖翔
동존암%피란감%당애국%라석파%오상
高效液相色谱法%犬尿喹啉酸%色氨酸%精神分裂症
高效液相色譜法%犬尿喹啉痠%色氨痠%精神分裂癥
고효액상색보법%견뇨규람산%색안산%정신분렬증
High performance liquid chromatography%Kynurenic acid%Tryptophan%Schizophrenia
目的 初步探讨血清犬尿喹啉酸(KYNA)含量及犬尿喹啉酸/色氨酸(TRP) 比值(KA/T)在精神分裂症患者抗精神药物治疗中的意义.方法 测定并比较了健康对照组、初始发病未用药SCH患者(SCH I组)、坚持用药SCH患者(SCH II组)血清KYNA、TRP含量及KA/T值.结果 与健康对照组血清KYNA (23.30±8.31)μmol/L、TRP(47.59±10.43)μmol/L比较,SCH I组患者血清KYNA(29.47±12.01)μmol/L和TRP(54.50±9.56)μmol/L含量均升高; SCH II组血清KYNA含量及KA/T比值下降.结论 抗精神药物治疗可能使血清KYNA含量和KA/T比值降低.
目的 初步探討血清犬尿喹啉痠(KYNA)含量及犬尿喹啉痠/色氨痠(TRP) 比值(KA/T)在精神分裂癥患者抗精神藥物治療中的意義.方法 測定併比較瞭健康對照組、初始髮病未用藥SCH患者(SCH I組)、堅持用藥SCH患者(SCH II組)血清KYNA、TRP含量及KA/T值.結果 與健康對照組血清KYNA (23.30±8.31)μmol/L、TRP(47.59±10.43)μmol/L比較,SCH I組患者血清KYNA(29.47±12.01)μmol/L和TRP(54.50±9.56)μmol/L含量均升高; SCH II組血清KYNA含量及KA/T比值下降.結論 抗精神藥物治療可能使血清KYNA含量和KA/T比值降低.
목적 초보탐토혈청견뇨규람산(KYNA)함량급견뇨규람산/색안산(TRP) 비치(KA/T)재정신분렬증환자항정신약물치료중적의의.방법 측정병비교료건강대조조、초시발병미용약SCH환자(SCH I조)、견지용약SCH환자(SCH II조)혈청KYNA、TRP함량급KA/T치.결과 여건강대조조혈청KYNA (23.30±8.31)μmol/L、TRP(47.59±10.43)μmol/L비교,SCH I조환자혈청KYNA(29.47±12.01)μmol/L화TRP(54.50±9.56)μmol/L함량균승고; SCH II조혈청KYNA함량급KA/T비치하강.결론 항정신약물치료가능사혈청KYNA함량화KA/T비치강저.
Objective To explore the clinical significance of serum value of kynurenic acid(KYNA) and KYNA/tryptophan (TRP) ratio (KA/T) in patients with schizophrenia(SCH). Methods The SCH patients (n=73) were divided into two groups (drug-naive, first episode patients, patients undergoing antipsychotic treatment) and the concentrations of serum KYNA, TRP in the Sch and health control(n=108) were measured. Results Compared with healthy control, there were significantly increased concentrations of serum KYNA and TRP in the drug-naive, first episode patients, and the serum KYNA and KA/T ratio were significantly decreased in patients undergoing antipsychotic treatment. Conclusion It showed that antipsychotic treatment may decrease the concentration of KYNA and value of KA/T.
