中国综合临床
中國綜閤臨床
중국종합림상
CLINICAL MEDICINE OF CHINA
2012年
8期
789-793
,共5页
卵巢肿瘤%组织型转谷氨酰胺酶%血管内皮生长因子
卵巢腫瘤%組織型轉穀氨酰胺酶%血管內皮生長因子
란소종류%조직형전곡안선알매%혈관내피생장인자
Ovarian neoplasms%Tissue transglutaminase%Vascular endothelial growth factor
目的 探讨组织型转谷氨酰胺酶(tTG)和血管内皮生长因子(VEGF)在上皮性卵巢癌中的表达及其与卵巢癌侵袭、转移的相关性.方法 应用免疫组化SP法对55例上皮性卵巢癌组织(卵巢癌组)、21例良性卵巢肿瘤组织(卵巢良性肿瘤组)中tTG、VEGF的表达情况进行检测,并分析其与临床病理指征的关系及二者表达的相关性.结果 tTG、VEGF在上皮性卵巢癌组织和卵巢良性肿瘤中的阳性表达率分别为92.7%(51/55)、38.1%(8/21)及90.9%(50/55)、47.6%(10/21),上皮性卵巢癌中的表达明显高于卵巢良性肿瘤组织,差异有统计学意义(x2值分别为32.620、19.570,P均<0.01).tTG在上皮性卵巢癌组织中的表达与临床分期(x2=13.286,P<0.01)、有无腹水(x2=17.247,P<0.01)有关;与病理学类型、组织学分级及淋巴结转移无关(P均>0.05).VEGF在上皮性卵巢癌组织中的表达与临床分期(x2=17.542,P<0.01)、组织学分级(x2=18.720,P<0.01)及有无腹水(x2=22.037,P<0.01)有关;与病理学类型、淋巴结转移无关(P均>0.05).tTG在上皮性卵巢癌基质细胞中的表达亦与临床分期(x2 =11.250,P<0.01)、有无腹水(x2=12.406,P<0.01)有关;与病理学类型、组织学分级及淋巴结转移无关(P均>0.05).VEGF在上皮性卵巢癌基质细胞中的表达与各项临床病理指标均无关(P均>0.05).上皮性卵巢癌组织中tTG蛋白表达与VEGF阳性表达呈显著相关(r=0.8856,x3=43.14,P<0.01).结论 tTG、VEGF共同表达在上皮性卵巢癌的发生、发展中起重要作用,二者的相互协同作用可能是促进卵巢癌发生、浸润和转移的重要因素.
目的 探討組織型轉穀氨酰胺酶(tTG)和血管內皮生長因子(VEGF)在上皮性卵巢癌中的錶達及其與卵巢癌侵襲、轉移的相關性.方法 應用免疫組化SP法對55例上皮性卵巢癌組織(卵巢癌組)、21例良性卵巢腫瘤組織(卵巢良性腫瘤組)中tTG、VEGF的錶達情況進行檢測,併分析其與臨床病理指徵的關繫及二者錶達的相關性.結果 tTG、VEGF在上皮性卵巢癌組織和卵巢良性腫瘤中的暘性錶達率分彆為92.7%(51/55)、38.1%(8/21)及90.9%(50/55)、47.6%(10/21),上皮性卵巢癌中的錶達明顯高于卵巢良性腫瘤組織,差異有統計學意義(x2值分彆為32.620、19.570,P均<0.01).tTG在上皮性卵巢癌組織中的錶達與臨床分期(x2=13.286,P<0.01)、有無腹水(x2=17.247,P<0.01)有關;與病理學類型、組織學分級及淋巴結轉移無關(P均>0.05).VEGF在上皮性卵巢癌組織中的錶達與臨床分期(x2=17.542,P<0.01)、組織學分級(x2=18.720,P<0.01)及有無腹水(x2=22.037,P<0.01)有關;與病理學類型、淋巴結轉移無關(P均>0.05).tTG在上皮性卵巢癌基質細胞中的錶達亦與臨床分期(x2 =11.250,P<0.01)、有無腹水(x2=12.406,P<0.01)有關;與病理學類型、組織學分級及淋巴結轉移無關(P均>0.05).VEGF在上皮性卵巢癌基質細胞中的錶達與各項臨床病理指標均無關(P均>0.05).上皮性卵巢癌組織中tTG蛋白錶達與VEGF暘性錶達呈顯著相關(r=0.8856,x3=43.14,P<0.01).結論 tTG、VEGF共同錶達在上皮性卵巢癌的髮生、髮展中起重要作用,二者的相互協同作用可能是促進卵巢癌髮生、浸潤和轉移的重要因素.
목적 탐토조직형전곡안선알매(tTG)화혈관내피생장인자(VEGF)재상피성란소암중적표체급기여란소암침습、전이적상관성.방법 응용면역조화SP법대55례상피성란소암조직(란소암조)、21례량성란소종류조직(란소량성종류조)중tTG、VEGF적표체정황진행검측,병분석기여림상병리지정적관계급이자표체적상관성.결과 tTG、VEGF재상피성란소암조직화란소량성종류중적양성표체솔분별위92.7%(51/55)、38.1%(8/21)급90.9%(50/55)、47.6%(10/21),상피성란소암중적표체명현고우란소량성종류조직,차이유통계학의의(x2치분별위32.620、19.570,P균<0.01).tTG재상피성란소암조직중적표체여림상분기(x2=13.286,P<0.01)、유무복수(x2=17.247,P<0.01)유관;여병이학류형、조직학분급급림파결전이무관(P균>0.05).VEGF재상피성란소암조직중적표체여림상분기(x2=17.542,P<0.01)、조직학분급(x2=18.720,P<0.01)급유무복수(x2=22.037,P<0.01)유관;여병이학류형、림파결전이무관(P균>0.05).tTG재상피성란소암기질세포중적표체역여림상분기(x2 =11.250,P<0.01)、유무복수(x2=12.406,P<0.01)유관;여병이학류형、조직학분급급림파결전이무관(P균>0.05).VEGF재상피성란소암기질세포중적표체여각항림상병리지표균무관(P균>0.05).상피성란소암조직중tTG단백표체여VEGF양성표체정현저상관(r=0.8856,x3=43.14,P<0.01).결론 tTG、VEGF공동표체재상피성란소암적발생、발전중기중요작용,이자적상호협동작용가능시촉진란소암발생、침윤화전이적중요인소.
Objective To investigate the expression of tissue transglutaminase(tTG) and vascular endothelial growth factor(VEGF) in epithelial ovarian carcinoma and the relationship of invasion and metastance in ovarian carcinoma.Methods The expression of tTG and VEGF was detected in 55 malignant and 21 benign ovarian neoplasms by immunohistochemical SP method.The clinical significance of tTG and VEGF and their relationship were analyzed.Results The expression rates of tTG and VEGF in malignant epithelial ovarian tumors were significantly higher than in benign epithelial ovarian tumors(tTG:92.7% vs.38.1%,x2 =32.620,P <0.01 ;VEGF:90.9% vs.47.6%,x2 =19.570,P <0.01).In ovarian cancer,the expression of tTG in tumor cells and stromal cells was significantly related to clinical phases and the presence of ascites.The expression of VEGF in tumor cells had a significant revelance to clinical phases,pathological grades and ascites.The expression of tTG in ovarian cancer cells was positively correlated with VEGF(r =0.8856,x2 =43.14,P <0.01).Conclusion Tissue transglutaminase and VEGF were detected not only in tumor cells,but also instromal cells.High expression of tTG and VEGF may play an importaant role in the pathogenesis of ovarian cancer and their synergistic effect may act as an important factor in promoting the invasion and metastasis of this cancer.