CAJ | 학술논문

目的探讨二甲双胍联合氯米芬-促性腺激素在多囊卵巢综合征(PCOS)患者治疗中的临床疗效观察.方法 60例PCOS患者,试验组应用二甲双胍联合氯米芬-促性腺激素,对照组只应用CC-hMG/hCG促排卵,具体使用方法同观察组.两组各治疗一个周期.结果两组治疗情况比较,观察组30例中,2例口服二甲双胍期间妊娠,28例促排卵治疗,有效27例,且均使用hCG诱发排卵,无反应1例;对照组促排卵治疗有效25例,1例因卵巢轻度刺激放弃hCG诱发排卵,无反应5例.有效病例中使用HMG治疗天数及用药剂量观察组分别(3.84±0.6)天和(7.84±1.8)支,对照组分别为(4.84±1.6)天和(9.34±2.7)支.两组比较差异有显著性(P<0.01).结论二甲双胍联合氯米芬可有效地改善PCOS患者的胰岛素抵抗,降低血雄激素水平,诱导排卵,并恢复生育功能.
목적 탐토이갑쌍고연합록미분-촉성선격소재다낭란소종합정(PCOS)환자치료중적림상료효관찰.방법 60례PCOS환자,시험조응용이갑쌍고연합록미분-촉성선격소,대조조지응용CC-hMG/hCG촉배란,구체사용방법동관찰조.량조각치료일개주기.결과 량조치료정황비교,관찰조30례중,2례구복이갑쌍고기간임신,28례촉배란치료,유효27례,차균사용hCG유발배란,무반응1례;대조조촉배란치료유효25례,1례인란소경도자격방기hCG유발배란,무반응5례.유효병례중사용HMG치료천수급용약제량관찰조분별(3.84±0.6)천화(7.84±1.8)지,대조조분별위(4.84±1.6)천화(9.34±2.7)지.량조비교차이유현저성(P<0.01).결론 이갑쌍고연합록미분가유효지개선PCOS환자적이도소저항,강저혈웅격소수평,유도배란,병회복생육공능.
Objective To investigate the clinical effects of metformin combined ovulation therapy on women with polycystie ovary syndrome(PCOS).Methods sixty-patients with PCOS were classified into 2 groups, the test group were treat by dimethyl biguanide and clomiphene and CC-hMG/hCG, the control group only used CC-hMG/hCG, all of them were be treated one cycle.Results there were 2 case had pregnancy during taking dimethyl biguanide orally. Effective case were 27, that is 27/28, and the time and the dose of use the CC-hMG/ hCG were (3.84±0.6)days and(7.84±1.8) rami individually, only one case were inefficacious.the control group had 25 effective case, and the time and the dose of use the CC-hMG/hCG were (4.84±1.6) days and (9.34±2.7) rami individually, there were significant difference between the two groups(P<0.05).Conclusion Metformin may effectively improve insulin resistance, reduce serum androgen level, and recover ovulation function in women with PCOS.