猪急性心肌梗死后骨髓干细胞自体移植对左心室重构的影响
저급성심기경사후골수간세포자체이식대좌심실중구적영향
Effects of bone marrow stem cells autologous transplantation on ventricular remodeling after acute myocardial infarction
  • 万方数据
    中国医师杂志 중국의사잡지
    JOURNAL OF CHINESE PHYSICIAN
    2008年 12期 1623-1625 ,共3页

    曾建平%周胜华%刘平%黄河%孙智山%吴名星%刘利华%孙建平%吴礼源%彭忮柳%刘颖%刘原%黄浩波

    증건평%주성화%류평%황하%손지산%오명성%류리화%손건평%오례원%팽기류%류영%류원%황호파

    心肌梗塞%干细胞移植%骨髓移植%心室重构%心室功能,左 心肌梗塞%榦細胞移植%骨髓移植%心室重構%心室功能,左
    심기경새%간세포이식%골수이식%심실중구%심실공능,좌
    Myocardial infarction%Stem cell transplantation%Bone marrow transplantation%Ventricular remodeling%Ventricularfunction,left
    目的 观察猪心肌梗死(心梗)后冠脉内注射移植骨髓干细胞时心室重_构的影响.方法 前降支球囊封堵法成功建立10头猪急性心肌梗死动物模型,随机均分为安慰刺组和移植组.造模1周后,移植组冠脉内注自体骨髓干细胞,安慰剂组注射1640培养基作为对照.造模前、造模后1周、造模后3月分别行心脏超声和SPECT检查,对比观察骨髓干细胞自体移植对急性心梗后左室重构的影响.结果与安慰剂组相比,移植组造模后3月时左室舒张内径更小,心尖室壁厚度更大,左室舒张末期容积更小,射血分数更高.结论 骨髓干细胞自体移植能有效减轻急性心肌梗死后左室重构.
    목적 관찰저심기경사(심경)후관맥내주사이식골수간세포시심실중_구적영향.방법 전강지구낭봉도법성공건립10두저급성심기경사동물모형,수궤균분위안위자조화이식조.조모1주후,이식조관맥내주자체골수간세포,안위제조주사1640배양기작위대조.조모전、조모후1주、조모후3월분별행심장초성화SPECT검사,대비관찰골수간세포자체이식대급성심경후좌실중구적영향.결과여안위제조상비,이식조조모후3월시좌실서장내경경소,심첨실벽후도경대,좌실서장말기용적경소,사혈분수경고.결론 골수간세포자체이식능유효감경급성심기경사후좌실중구.
    Objective To investigate the effects of bone marrow stem cells autologous transplantation on left ventricular remodeling after acute myocardial infarction. Methods Acute myocardial infarction models were successfully established in 10 swines, which were ran-dom divided into two groups, placebo group and trasplantation group. One week after operation, bone marrow stem cells autologous transplan-tation was performed, and control group was administrated with placebo. B-ultrasound and emission computed tomography aexaminations were performed to assess the left ventrieular end diastolic dimension, left ventricular tip wall thickness, left ventricular end diastolic volume and left ventricula ejection fraction before operation, one week, three months after acute myocardial infarction. Results Compared with that of control group, three months after acute myocardial infarction, transplantation group witnessed smaller left ventricular end diastolic dimension, thicker left ventricular tip wall, smaller left ventricular end diastolic volume and higher left ventricular ejection fraction. Conclusions Bone marrow autologous transplantation after acute myocardial infarction can alleviate left ventricular remodeling.
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