CAJ | 학술논문

目的探讨40岁以下青年非小细胞肺癌(NSCLC)患者的生存状况,分析其预后影响因素.方法回顾性分析148例青年NSCLC患者的临床病理资料,采用Kaplan-Meier法和Cox回归法分析各因素对预后的影响.结果随访6 ～ 148个月,随访率为100％.全组死亡122例,生存26例.全组患者的1、3、5年生存率分别为54.7％、10.4％和5.6％,中位生存时间为14.7个月.单因素分析结果显示,KPS评分、临床分期、治疗方式和血清癌胚抗原(CEA)水平与青年NSCLC患者的预后有关(均P＜0.05).Cox多因素分析结果显示,KPS评分、临床分期、治疗方式以及血清CEA水平均是影响青年NSCLC患者预后的独立因素(均P＜0.05).结论 KPS评分、临床分期、治疗方式以及血清CEA水平是影响青年NSCLC患者预后的独立因素.
목적 탐토40세이하청년비소세포폐암(NSCLC)환자적생존상황,분석기예후영향인소.방법 회고성분석148례청년NSCLC환자적림상병리자료,채용Kaplan-Meier법화Cox회귀법분석각인소대예후적영향.결과 수방6 ～ 148개월,수방솔위100％.전조사망122례,생존26례.전조환자적1、3、5년생존솔분별위54.7％、10.4％화5.6％,중위생존시간위14.7개월.단인소분석결과현시,KPS평분、림상분기、치료방식화혈청암배항원(CEA)수평여청년NSCLC환자적예후유관(균P＜0.05).Cox다인소분석결과현시,KPS평분、림상분기、치료방식이급혈청CEA수평균시영향청년NSCLC환자예후적독립인소(균P＜0.05).결론 KPS평분、림상분기、치료방식이급혈청CEA수평시영향청년NSCLC환자예후적독립인소.
Objective To investigate the prognostic factors for non-small ccll lung cancer(NSCLC)in patients under 40 years of age.Methods The clinicopathological data of 148 young patients with NSCLC were retrospectively analyzed.Kaplan-Meier and Cox regression analyses were used to analyze the relationship between prognostic factors and survival time.Results The patients were followed-up for 6-148 months,and the follow-up rate was 100％.In the whole group,122 patients died and 26 cases were surviving.The 1-,3-and 5-year survival rates were 54.7％,10.4％ and 5.6％,respectively.The median survival time (MST) was 14.7 months.Kaplan-Meier analysis showed that Karnofsky performance status (KPS),clinical stage,treatment modality and serum CEA were related with prognosis (P ＜ 0.05).Multivariate analysis indicated that KPS,clinical stage,treatment modality and serum CEA were independent prognostic factors (P ＜ 0.05).Conclusions KPS,CEA,clinical stage and treatment modalities are independent prognostic factors in young NSCLC patients.