CAJ | 학술논문

目的通过对比分析两个不同时期肺癌患者合并下呼吸道感染的致病菌和对抗生素的敏感性,为临床合理使用抗生素提供依据.方法以1991年372例和2001年572例我院肺癌住院病人为研究对象进行回顾性研究.结果 1991年组革兰氏阳性菌(GPC)占26.8%,革兰氏阴性菌(GNB)占625%,2001年组GPC占 38.5%,GNB占50%;1991年组主要病原菌为克雷伯杆菌(26.8%)、金葡茵(16.1%)、肠杆菌( 14.3%)、绿脓杆菌(12.5%),2001年组主要为肠杆菌(17.3%)、肺炎链球菌(13.5%)、霉菌(11.5%)、流感嗜血杆菌( 9.6%)和表皮葡萄球菌(9.6%).结论两组致病菌均以革兰氏阴性菌为主,但2001年主要致病菌的分布发生了变迁,革兰氏阳性菌和条件致病菌、霉菌所占比例增高.药敏分析显示2001年来多种抗生素的敏感性较1991年有所下降,但现常用抗生素仍然有效.
목적통과대비분석량개불동시기폐암환자합병하호흡도감염적치병균화대항생소적민감성,위림상합리사용항생소제공의거.방법이1991년372례화2001년572례아원폐암주원병인위연구대상진행회고성연구.결과 1991년조혁란씨양성균(GPC)점26.8%,혁란씨음성균(GNB)점625%,2001년조GPC점 38.5%,GNB점50%;1991년조주요병원균위극뢰백간균(26.8%)、금포인(16.1%)、장간균( 14.3%)、록농간균(12.5%),2001년조주요위장간균(17.3%)、폐염련구균(13.5%)、매균(11.5%)、류감기혈간균( 9.6%)화표피포도구균(9.6%).결론량조치병균균이혁란씨음성균위주,단2001년주요치병균적분포발생료변천,혁란씨양성균화조건치병균、매균소점비례증고.약민분석현시2001년래다충항생소적민감성교1991년유소하강,단현상용항생소잉연유효.
Objective:For the reasonable use of antibiotics, pathogens for lower-respiratory-tract infection and their drug sensibility were contrastively analyzedin lung cancer patients during two different periods.Methods:The medical records of 372 patients in 1991 and 572 patients in 2001 were retrospectively studied.Results: The gram-positive cocci(GPC) ccounted for 26.8% and the Gram-negative bacilli(GNB) for 62.5% in 1991;GPC in 2001 accounted for 38.5% and GNB for 50% in 2001.The predominant bacteria were in the following order:Klebsiella(26.8%),Staphylococcus aureus(16.1%), Enteric bacilli(14.3%),Pseudomonas(12.5 %) in 1991;and Enteric bacilli(17.3 %),Pneumococcal(13.5 %),Mold(11.5 %),Heamophilus(9.6 %),Staphylococcus epidermis(9.6 %).Conclusions:The predominant bacteria in the two groups were both Gram-negative bacilli,however,the ratio of gram-positive cocci, conditioned pathogens and mold was higher in 2001 than in 1991.The sensibility of many drugs in 2001 fell in various degrees compared with that in 1999,but croutine antibiotics are still effective now.