中华创伤杂志
中華創傷雜誌
중화창상잡지
Chinese Journal of Traumatology
2011年
8期
737-741
,共5页
马佳滨%周磊%闫景龙%昌广平%潘华兴%奚春阳%祖佳宁%姬烨%李燕京%关智慧
馬佳濱%週磊%閆景龍%昌廣平%潘華興%奚春暘%祖佳寧%姬燁%李燕京%關智慧
마가빈%주뢰%염경룡%창엄평%반화흥%해춘양%조가저%희엽%리연경%관지혜
磷酸钙类%骨移植%骨替用物%磷酸钙骨水泥
燐痠鈣類%骨移植%骨替用物%燐痠鈣骨水泥
린산개류%골이식%골체용물%린산개골수니
Calcium phosphates%Bone transplantation%Bone substitutes%Calcium phosphate bone cement
目的 探讨不同纤维配比的复合人工骨修复兔桡骨缺损的成骨效果。方法 选用新西兰大白兔36只,完全随机化设计分为A、B、C、D四组,将其双侧桡骨制备成骨缺损模型,取其自体髂骨制成直径为300 - 500 μm的微小颗粒骨,将磷酸钙骨水泥(calcium phosphate cement,CPC)/颗粒骨与聚磷酸钙纤维(calcium polyphosphate fiber,CPPF)均匀混合成CPC/CPPF复合材料,按照CPPF占CPC/CPPF复合材料重量的0、10%、30%、50%分为四组,将上述四组CPC/CPPF复合材料与微小颗粒骨以6:4固定比例混合均匀,分别植入A、B、C、D四组兔桡骨缺损处,在4,8周分别行大体、X线片和组织学观察,8周时行力学测试。结果 当CPPF占CPC/CPPF复合材料的30%时,最大抗压负荷及抗弯负荷均优于其他组(p<0.05),组织学显示人工复合材料与骨组织界面结合最为紧密,材料降解速率与组织成骨速率最接近,成骨性最佳,比例最优。结论 通过向CPC/CPPF中加入一定比例颗粒骨来调节复合材料降解速率,使之与兔桡骨成骨速率相适应,以获得修复兔桡骨缺损的最佳复合人工骨。
目的 探討不同纖維配比的複閤人工骨脩複兔橈骨缺損的成骨效果。方法 選用新西蘭大白兔36隻,完全隨機化設計分為A、B、C、D四組,將其雙側橈骨製備成骨缺損模型,取其自體髂骨製成直徑為300 - 500 μm的微小顆粒骨,將燐痠鈣骨水泥(calcium phosphate cement,CPC)/顆粒骨與聚燐痠鈣纖維(calcium polyphosphate fiber,CPPF)均勻混閤成CPC/CPPF複閤材料,按照CPPF佔CPC/CPPF複閤材料重量的0、10%、30%、50%分為四組,將上述四組CPC/CPPF複閤材料與微小顆粒骨以6:4固定比例混閤均勻,分彆植入A、B、C、D四組兔橈骨缺損處,在4,8週分彆行大體、X線片和組織學觀察,8週時行力學測試。結果 噹CPPF佔CPC/CPPF複閤材料的30%時,最大抗壓負荷及抗彎負荷均優于其他組(p<0.05),組織學顯示人工複閤材料與骨組織界麵結閤最為緊密,材料降解速率與組織成骨速率最接近,成骨性最佳,比例最優。結論 通過嚮CPC/CPPF中加入一定比例顆粒骨來調節複閤材料降解速率,使之與兔橈骨成骨速率相適應,以穫得脩複兔橈骨缺損的最佳複閤人工骨。
목적 탐토불동섬유배비적복합인공골수복토뇨골결손적성골효과。방법 선용신서란대백토36지,완전수궤화설계분위A、B、C、D사조,장기쌍측뇨골제비성골결손모형,취기자체가골제성직경위300 - 500 μm적미소과립골,장린산개골수니(calcium phosphate cement,CPC)/과립골여취린산개섬유(calcium polyphosphate fiber,CPPF)균균혼합성CPC/CPPF복합재료,안조CPPF점CPC/CPPF복합재료중량적0、10%、30%、50%분위사조,장상술사조CPC/CPPF복합재료여미소과립골이6:4고정비례혼합균균,분별식입A、B、C、D사조토뇨골결손처,재4,8주분별행대체、X선편화조직학관찰,8주시행역학측시。결과 당CPPF점CPC/CPPF복합재료적30%시,최대항압부하급항만부하균우우기타조(p<0.05),조직학현시인공복합재료여골조직계면결합최위긴밀,재료강해속솔여조직성골속솔최접근,성골성최가,비례최우。결론 통과향CPC/CPPF중가입일정비례과립골래조절복합재료강해속솔,사지여토뇨골성골속솔상괄응,이획득수복토뇨골결손적최가복합인공골。
Objective To explore the effect of the calcium phosphate cement (CPC) /calcium polyphosphate fiber (CPPF) composites mixed with different proportion of minimal morselized bone on repair of bone defect in vivo. Methods A total of 36 New Zealand white rabbits were completely randomly designed into A, B, C, D groups and their bilateral radial bone defect model was prepared. The minimal morselized bone (300-500 μm in diameter) was made from the iliac of those rats. The CPPF and CPC were evenly mixed into CPC/CPPF composites which were divided into four groups in accordance with the CPPF weight O, 10%, 30% and 50% in CPC/CPPF composite. The CPC/CPPF composites of the four groups was mixed with the minimal morselized bone with ratio of 6:4 and then the mixture was implanted the bone defect of the rabbits in four groups. The gross, X-ray and histological observations were done at four and eight weeks. The biomechanical test was performed at eight weeks. Results When CPPF occupies 30% of the CPC/CPPF composite, the maximum compressive load and bending loads were better than those in the other groups ( P < 0.05 ), when the histological observation showed the most tight link between the artificial composite and the bone interface and the closest similarity between material degradation rate and the ossification rate, with the best osteogenesis and the optimal ratio.Conclusion The repair of bone defect can attain the optimal outcome through adding a certain ratio of minimal morselized bone into the CPC/CPPF to adjust the degradation rate of composites.