中华行为医学与脑科学杂志
中華行為醫學與腦科學雜誌
중화행위의학여뇌과학잡지
CHINESE JOURNAL OF BEHAVIORAL MEDICINE AND BRAIN SCIENCE
2012年
6期
527-529
,共3页
崔立谦%蒋莉君%邓伟%黄朝华%陈壮飞%李名立%王强%王英成%马小红%龚启勇%李涛
崔立謙%蔣莉君%鄧偉%黃朝華%陳壯飛%李名立%王彊%王英成%馬小紅%龔啟勇%李濤
최립겸%장리군%산위%황조화%진장비%리명립%왕강%왕영성%마소홍%공계용%리도
精神分裂症%额叶%海马%磁共振波谱学
精神分裂癥%額葉%海馬%磁共振波譜學
정신분렬증%액협%해마%자공진파보학
Schizophrenia%Frontal lobe%Hippocampus%Magnetic resonance spectroscopy
目的 探讨首发精神分裂症患者未患病父母额叶白质、海马氢质子磁共振质子波谱(1H-MRS)变化特点.方法 对首发精神分裂症患者未患病父亲19例、男性正常对照19例、未患病母亲24例、女性正常对照24例进行氢质子波谱扫描,检测双侧额叶白质和海马的N-乙酰天门冬氨酸(NAA)、胆碱(Cho)和肌酸(Cr),以Cr为参照物,分别计算双侧NAA/Cr、Cho/Cr比值.采用配对t检验、独立样本t检验进行统计分析.结果 未患病母亲组双侧额叶白质Cho/Cr[左侧(1.10±0.13),右侧(1.08±0.12)]均高于女性正常对照组[左侧(1.03±0.10),右侧(1.02±0.09)],差异有统计学意义(t=2.21,2.23,P＜0.05).女性正常对照组左侧额叶NAA/Cr(1.64±0.12)比右侧额叶(1.74±0.13)低,差异有统计学意义( t=3.16,P=0.004),而未患病母亲组前额白质左右侧NAA/Cr差异无统计学意义(P＞0.05).未患病父亲组额叶白质、海马双侧NAA/Cr和Cho/Cr与男性正常对照相比差异无统计学意义(P＞0.05).结论 未患病母亲组额叶白质存有代谢物水平异常和NAA/Cr非对称性的消失.
目的 探討首髮精神分裂癥患者未患病父母額葉白質、海馬氫質子磁共振質子波譜(1H-MRS)變化特點.方法 對首髮精神分裂癥患者未患病父親19例、男性正常對照19例、未患病母親24例、女性正常對照24例進行氫質子波譜掃描,檢測雙側額葉白質和海馬的N-乙酰天門鼕氨痠(NAA)、膽堿(Cho)和肌痠(Cr),以Cr為參照物,分彆計算雙側NAA/Cr、Cho/Cr比值.採用配對t檢驗、獨立樣本t檢驗進行統計分析.結果 未患病母親組雙側額葉白質Cho/Cr[左側(1.10±0.13),右側(1.08±0.12)]均高于女性正常對照組[左側(1.03±0.10),右側(1.02±0.09)],差異有統計學意義(t=2.21,2.23,P＜0.05).女性正常對照組左側額葉NAA/Cr(1.64±0.12)比右側額葉(1.74±0.13)低,差異有統計學意義( t=3.16,P=0.004),而未患病母親組前額白質左右側NAA/Cr差異無統計學意義(P＞0.05).未患病父親組額葉白質、海馬雙側NAA/Cr和Cho/Cr與男性正常對照相比差異無統計學意義(P＞0.05).結論 未患病母親組額葉白質存有代謝物水平異常和NAA/Cr非對稱性的消失.
목적 탐토수발정신분렬증환자미환병부모액협백질、해마경질자자공진질자파보(1H-MRS)변화특점.방법 대수발정신분렬증환자미환병부친19례、남성정상대조19례、미환병모친24례、녀성정상대조24례진행경질자파보소묘,검측쌍측액협백질화해마적N-을선천문동안산(NAA)、담감(Cho)화기산(Cr),이Cr위삼조물,분별계산쌍측NAA/Cr、Cho/Cr비치.채용배대t검험、독립양본t검험진행통계분석.결과 미환병모친조쌍측액협백질Cho/Cr[좌측(1.10±0.13),우측(1.08±0.12)]균고우녀성정상대조조[좌측(1.03±0.10),우측(1.02±0.09)],차이유통계학의의(t=2.21,2.23,P＜0.05).녀성정상대조조좌측액협NAA/Cr(1.64±0.12)비우측액협(1.74±0.13)저,차이유통계학의의( t=3.16,P=0.004),이미환병모친조전액백질좌우측NAA/Cr차이무통계학의의(P＞0.05).미환병부친조액협백질、해마쌍측NAA/Cr화Cho/Cr여남성정상대조상비차이무통계학의의(P＞0.05).결론 미환병모친조액협백질존유대사물수평이상화NAA/Cr비대칭성적소실.
Objective To examine biochemical characteristics of the frontal lobe and hippocampus in unaffected parents of schizophrenia prohands using proton magnetic resonance spectroscopy (1H-MRS).Method 19 unaffected fathers of schizophrenia probands with matched 19 male healthy control subjects and 24 unaffected mothers of schizophrenia probands with matched 24 female healthy control subjects were included in the study.1 H-MRS was performed in two sides of the hippocampus and frontal lobes regions.The ratios of N-Acetylaspartate ( NAA ),choline (Cho) to creatine (Cr) were measured.One-sample T test and paired-samples t test were used for statistic process.Results Unaffected mothers of schizophrenia probands had a higher Cho/Cr ratio ( left ( 1.10 ± 0.13,right ( 1.08 ± 0.12 ) ) in the frontal white matter compared with matched female health control subjects(left( 1.03 ± 0.10),right( 1.02 ± 0.09 )).The NAA/Cr ratio was significantly reduced in the left frontal white matter of female health control subjects compared to right( 1.64 ± 0.12 vs 1.74 ± 0.13 ),but this difference was not observed in unaffected mothers of schizophrenia probands.There were no significant differences in metabolites for frontal lobe and hippocampus regions between unaffected fathers of schizophrenia probands and male healthy control subjects groups( all P＞0.05 ).Conclusion The results implicate that the metabolic abnormalities and disappeared asymmetry of NAA/Cr might exist in the frontal white matter among unaffected mothers of schizophrenia probands.
