中国综合临床
中國綜閤臨床
중국종합림상
CLINICAL MEDICINE OF CHINA
2012年
10期
1031-1033
,共3页
叶励超%蔡若蔚%黄玉婷%洪志林%钱加强
葉勵超%蔡若蔚%黃玉婷%洪誌林%錢加彊
협려초%채약위%황옥정%홍지림%전가강
多发性硬化%不宁腿综合征
多髮性硬化%不寧腿綜閤徵
다발성경화%불저퇴종합정
Multiple sclerosis%Restless legs syndrome
目的 探讨多发性硬化(MS)患者合并不宁腿综合征(RLS)的临床特点,且进一步研究MS患者合并RLS的相关因素.方法 选取确诊的70例MS患者,根据是否合并RLS分为伴RLS组和单纯MS组,比较两组患者的MS发病年龄、病程及神经功能损害严重程度(EDSS评分)等临床资料;分析RLS症状严重程度与EDSS的关系.结果 70例MS患者中12例合并RIS,发生率为17.1％(12/70).伴RLS组患者发病年龄为(47.6±10.0)岁,单纯MS组为(40.1 ±10.4)岁,两组比较差异有统计学意义(=2.29,P=0.030);病程分别为(12.6±6.8)、(8.2±6.6)年,两组比较差异有统计学意义(t =2.10,P=0.039);EDSS评分分别为(4.5±2.5)、(2.5±2.0)分,两组比较差异有统计学意义(t=3.02,P=0.004).RLS严重程度评分与EDSS评分无相关性(r=0.45,P=0.15).结论 RLS在MS患者中发病率较高,MS发病年龄越大,病程越长,神经功能损害越严重,发生RLS的可能性越大.
目的 探討多髮性硬化(MS)患者閤併不寧腿綜閤徵(RLS)的臨床特點,且進一步研究MS患者閤併RLS的相關因素.方法 選取確診的70例MS患者,根據是否閤併RLS分為伴RLS組和單純MS組,比較兩組患者的MS髮病年齡、病程及神經功能損害嚴重程度(EDSS評分)等臨床資料;分析RLS癥狀嚴重程度與EDSS的關繫.結果 70例MS患者中12例閤併RIS,髮生率為17.1％(12/70).伴RLS組患者髮病年齡為(47.6±10.0)歲,單純MS組為(40.1 ±10.4)歲,兩組比較差異有統計學意義(=2.29,P=0.030);病程分彆為(12.6±6.8)、(8.2±6.6)年,兩組比較差異有統計學意義(t =2.10,P=0.039);EDSS評分分彆為(4.5±2.5)、(2.5±2.0)分,兩組比較差異有統計學意義(t=3.02,P=0.004).RLS嚴重程度評分與EDSS評分無相關性(r=0.45,P=0.15).結論 RLS在MS患者中髮病率較高,MS髮病年齡越大,病程越長,神經功能損害越嚴重,髮生RLS的可能性越大.
목적 탐토다발성경화(MS)환자합병불저퇴종합정(RLS)적림상특점,차진일보연구MS환자합병RLS적상관인소.방법 선취학진적70례MS환자,근거시부합병RLS분위반RLS조화단순MS조,비교량조환자적MS발병년령、병정급신경공능손해엄중정도(EDSS평분)등림상자료;분석RLS증상엄중정도여EDSS적관계.결과 70례MS환자중12례합병RIS,발생솔위17.1％(12/70).반RLS조환자발병년령위(47.6±10.0)세,단순MS조위(40.1 ±10.4)세,량조비교차이유통계학의의(=2.29,P=0.030);병정분별위(12.6±6.8)、(8.2±6.6)년,량조비교차이유통계학의의(t =2.10,P=0.039);EDSS평분분별위(4.5±2.5)、(2.5±2.0)분,량조비교차이유통계학의의(t=3.02,P=0.004).RLS엄중정도평분여EDSS평분무상관성(r=0.45,P=0.15).결론 RLS재MS환자중발병솔교고,MS발병년령월대,병정월장,신경공능손해월엄중,발생RLS적가능성월대.
Objective To investigate the clinical features of patients with multiple sclerosis (MS) and restless legs syndrome (RLS) and to further examine relevant factors that may contribute to the co-occurrence of MS and RLS.Methods Seventy MS patients were recruited in the present study.The RLS screen was further performed in MS patients based on the diagnostic criteria for RLS.MS patients with RLS were designated as the case group and MS patients without RLS served as the control group.The clinical data including age of MS onset,MS duration and clinical disability by the expanded disability status scale (EDSS) were analyzed.Results There were 12 MS patients with RLS in total 70 MS patients and the incidence rate was 17.1％.The average age of MS onset in the RLS group was (47.6 ± 10.0) years,and (40.1 ± 10.4 ) years in the control group.The difference of average age of MS onset was found to be significant (t =2.29,P =0.030).The average history of MS in the RLS group was ( 12.6 ± 6.8 ) years,and ( 8.2 ± 6.6) years in the control group ( t =2.10,P =0.039).The average EDSS of the RLS group was 4.5 ±2.5,and 2.5 ±2.0 in the control group (t =3.02,P =0.004).There was no significant association between RLSRS and EDSS in MS patients with RLS (P =0.15).Conclusion The incidence rate of RLS in MS patients was high.Among patients with MS,RLS was associated with older age,longer MS duration,and more severe disability.
