中国临床实用医学
中國臨床實用醫學
중국림상실용의학
CHINA CLINICAL PRACTICAL MEDICINE
2010年
5期
42-44
,共3页
王宝宏%刘秀香%张海鸿%张鑫雨
王寶宏%劉秀香%張海鴻%張鑫雨
왕보굉%류수향%장해홍%장흠우
尿激活素A%新生儿%缺氧缺血%诊断%病情判断
尿激活素A%新生兒%缺氧缺血%診斷%病情判斷
뇨격활소A%신생인%결양결혈%진단%병정판단
Urinary activin A%Newborn%Hypoxia-ischemia%Diagnosis%Condition to determine
目的 观察窒息新生儿尿激活素A含量的变化,探讨尿激活素A与新生儿缺氧缺血性脑病(hypoxic-ischemic encephalopathy;HIE)的关系,为HIE的诊断及病情判断提供重要依据.方法 选择50例窒息足月新生儿为观察组,随机选择48例同期出生正常足月新生儿为正常对照组.生后7 d内根据新生儿缺氧缺血性脑病诊断标准和临床分度,将50例窒息新生儿分成轻度HIE组30例、中重度HIE组20例.采用ELISA方法检测两组新生儿生后不同时间(2、12、24、48、72h)尿激活素A的含量.结果 中重度HIE组尿激活素A含量显著高于正常对照组(P＜0.01)和轻度HIE组(P＜0.01);正常对照组和轻度HIE组尿激活素A含量无显著性差异(P＞0.05).以尿激活素A含量＞70 ng/L为临界值判断中重度HIE发生,2 h尿激活素A含量的敏感度为82%、特异度为99%;12～72 h尿激活素A含量的敏感度为100%、特异度为98%.结论 尿激活素A含量与HIE病情程度呈正相关,对判断中重度HIE的发生有高度的敏感性及特异性,为诊断中重度HIE提供重要依据.
目的 觀察窒息新生兒尿激活素A含量的變化,探討尿激活素A與新生兒缺氧缺血性腦病(hypoxic-ischemic encephalopathy;HIE)的關繫,為HIE的診斷及病情判斷提供重要依據.方法 選擇50例窒息足月新生兒為觀察組,隨機選擇48例同期齣生正常足月新生兒為正常對照組.生後7 d內根據新生兒缺氧缺血性腦病診斷標準和臨床分度,將50例窒息新生兒分成輕度HIE組30例、中重度HIE組20例.採用ELISA方法檢測兩組新生兒生後不同時間(2、12、24、48、72h)尿激活素A的含量.結果 中重度HIE組尿激活素A含量顯著高于正常對照組(P＜0.01)和輕度HIE組(P＜0.01);正常對照組和輕度HIE組尿激活素A含量無顯著性差異(P＞0.05).以尿激活素A含量＞70 ng/L為臨界值判斷中重度HIE髮生,2 h尿激活素A含量的敏感度為82%、特異度為99%;12～72 h尿激活素A含量的敏感度為100%、特異度為98%.結論 尿激活素A含量與HIE病情程度呈正相關,對判斷中重度HIE的髮生有高度的敏感性及特異性,為診斷中重度HIE提供重要依據.
목적 관찰질식신생인뇨격활소A함량적변화,탐토뇨격활소A여신생인결양결혈성뇌병(hypoxic-ischemic encephalopathy;HIE)적관계,위HIE적진단급병정판단제공중요의거.방법 선택50례질식족월신생인위관찰조,수궤선택48례동기출생정상족월신생인위정상대조조.생후7 d내근거신생인결양결혈성뇌병진단표준화림상분도,장50례질식신생인분성경도HIE조30례、중중도HIE조20례.채용ELISA방법검측량조신생인생후불동시간(2、12、24、48、72h)뇨격활소A적함량.결과 중중도HIE조뇨격활소A함량현저고우정상대조조(P＜0.01)화경도HIE조(P＜0.01);정상대조조화경도HIE조뇨격활소A함량무현저성차이(P＞0.05).이뇨격활소A함량＞70 ng/L위림계치판단중중도HIE발생,2 h뇨격활소A함량적민감도위82%、특이도위99%;12～72 h뇨격활소A함량적민감도위100%、특이도위98%.결론 뇨격활소A함량여HIE병정정도정정상관,대판단중중도HIE적발생유고도적민감성급특이성,위진단중중도HIE제공중요의거.
Objective To explore the relationship between urinary activin A and neonatal hypoxic-ischemic encephalopathy(HIE)by observing the change of urinary activin A in neonates with asphyxia,Provides the important basis for the HIE diagnosis and the condition judgment.Methods 50 cases of neonatal asphyxia term were the observation group ,48 cases of normal full-term newborns born in the same period were stochastically the normal control group.Within 7 days after birth,50 cases of neonatal asphyxia were divided into the group of 30 patients with mild HIE and the group of 20 patients with moderate and severe HIE,according to diagnostic criteria and clinical grading of neonatal hypoxic-ischemic encephalopathy.the levels of urinary activin A in two groups after birth different time(2,12,24,48,72 h) were determined by using ELISA method.Results The levels of urinary activin A in moderate and severe HIE group was significantly higher than the normal control group (P ＜ 0.01)and mild HIE group (P ＜ 0.01); The levels of urinary activin A in the normal control group and mild HIE group showed no significant differences (P ＞ 0.05).Urinary activin A levels ＞ 70 ng/L for the critical value to determine the occurrence of moderate and severe HIE,the sensitivity and specificity of 2 h urinary activin A levels were separately 82% and 99% ;the sensitivity and specificity of 12-72 h urinary activin A levels were separately 100%and 98%.Conclusion The correlation between the levels of urinary activin A and the severity of HIE was positive,the levels of urinary activin A had a high degree of sensitivity and specificity for determine the incidence of moderate and severe HIE,it provided an important basis for diagnosis of moderate and severe HIE.
