中国实用医刊
中國實用醫刊
중국실용의간
CENTRAL PLAINS MEDICAL JOURNAL
2011年
15期
30-32
,共3页
代谢综合征%冠状动脉疾病%氧化修饰型低密度脂蛋白%胰岛素抵抗
代謝綜閤徵%冠狀動脈疾病%氧化脩飾型低密度脂蛋白%胰島素牴抗
대사종합정%관상동맥질병%양화수식형저밀도지단백%이도소저항
Metabolic syndrome%Coronary artery disease%Oxidized low density lipoprotein%Insulin resistance
目的 探讨代谢综合征(MS)及合并冠心病(CHD)患者氧化修饰型低密度脂蛋白(ox-LDL)水平与胰岛素抵抗及MS其他指标的关系.方法 用酶联免疫吸附法(ELISA)测定单纯MS组(17例)、MS合并CHD组(40例)和正常对照组(19例)ox-LDL水平和空腹血浆真胰岛素水平,并收集MS的其他有关数据:腰围、体质量指数、空腹血糖和血脂,计算胰岛素敏感指数(ISI).结果 ①ox-LDL水平在正常对照组为(6±5)μg/L,MS组为(25±12)μg/L,MS合并CHD组为(41±36)μg/L,三组比较差异有统计学意义(F=11.48,P<0.05);②ox-LDL水平与ISI呈负相关(r=-0.472,P<0.05),与体质量指数、腰围、低密度脂蛋白胆固醇、空腹真胰岛素无明显相关性;③以ox-LDL水平为应变量的多元逐步回归分析提示,胰岛素敏感指数(r2=0.224)与ox-LDL具有相关性,体质量指数、腰围、低密度脂蛋白胆固醇、空腹真胰岛素与氧化低密度脂蛋白无明显相关性.结论 MS患者的ox-LDL水平增加,合并CHD的MS患者更为明显,并与胰岛素抵抗相关,可能在MS发展为CHD中起一定作用.
目的 探討代謝綜閤徵(MS)及閤併冠心病(CHD)患者氧化脩飾型低密度脂蛋白(ox-LDL)水平與胰島素牴抗及MS其他指標的關繫.方法 用酶聯免疫吸附法(ELISA)測定單純MS組(17例)、MS閤併CHD組(40例)和正常對照組(19例)ox-LDL水平和空腹血漿真胰島素水平,併收集MS的其他有關數據:腰圍、體質量指數、空腹血糖和血脂,計算胰島素敏感指數(ISI).結果 ①ox-LDL水平在正常對照組為(6±5)μg/L,MS組為(25±12)μg/L,MS閤併CHD組為(41±36)μg/L,三組比較差異有統計學意義(F=11.48,P<0.05);②ox-LDL水平與ISI呈負相關(r=-0.472,P<0.05),與體質量指數、腰圍、低密度脂蛋白膽固醇、空腹真胰島素無明顯相關性;③以ox-LDL水平為應變量的多元逐步迴歸分析提示,胰島素敏感指數(r2=0.224)與ox-LDL具有相關性,體質量指數、腰圍、低密度脂蛋白膽固醇、空腹真胰島素與氧化低密度脂蛋白無明顯相關性.結論 MS患者的ox-LDL水平增加,閤併CHD的MS患者更為明顯,併與胰島素牴抗相關,可能在MS髮展為CHD中起一定作用.
목적 탐토대사종합정(MS)급합병관심병(CHD)환자양화수식형저밀도지단백(ox-LDL)수평여이도소저항급MS기타지표적관계.방법 용매련면역흡부법(ELISA)측정단순MS조(17례)、MS합병CHD조(40례)화정상대조조(19례)ox-LDL수평화공복혈장진이도소수평,병수집MS적기타유관수거:요위、체질량지수、공복혈당화혈지,계산이도소민감지수(ISI).결과 ①ox-LDL수평재정상대조조위(6±5)μg/L,MS조위(25±12)μg/L,MS합병CHD조위(41±36)μg/L,삼조비교차이유통계학의의(F=11.48,P<0.05);②ox-LDL수평여ISI정부상관(r=-0.472,P<0.05),여체질량지수、요위、저밀도지단백담고순、공복진이도소무명현상관성;③이ox-LDL수평위응변량적다원축보회귀분석제시,이도소민감지수(r2=0.224)여ox-LDL구유상관성,체질량지수、요위、저밀도지단백담고순、공복진이도소여양화저밀도지단백무명현상관성.결론 MS환자적ox-LDL수평증가,합병CHD적MS환자경위명현,병여이도소저항상관,가능재MS발전위CHD중기일정작용.
Objective To investigate the relationship between oxidized low density lipoprotein and insulin resistance,the metabolic parameters in patients with metabolic syndrome(MS) or MS complicated with coronary heart disease(MS+CHD).Methods Oxidized low density lipoprotein level and fasting plasma insulin levels were measured by enzyme linked immunosorbent assay method in 17 MS patients , 40 MS+CHD patients and 19 healthy controls. Other information on conventional clinical features of MS, such as waist, BMI, fasting blood glucose and blood fat were collected and the insulin sensitivity index(ISI)were calculated.Results ①There was significant difference in oxidized low density lipoprotein concentrations between controls [(6±5)μg/L] , patients with MS[(25±12)μg/L] and patients with MS+CHD[(41±36)μg/L].② Correlation analysis results suggested that the oxidized low density lipoprotein concentration was related to insulin sensitivity index(r=-0.472,P<0.05),there was no obvious relationship between oxidized low density lipoprotein concentration and the metabolic parameters including body mass index, waist, low density lipoprotein cholesterol and fasting insulin. ③Logistic regression analysis indicated a statistically significant relationship between oxidized low density lipoprotein concentration and ISI ( r 2 = 0. 224, P < 0. 05 ) , the metabolic parameters including body mass index, waist, low density lipoprotein cholesterol, fasting insulin were not correlated with oxidized low density lipoprotein. Conclusions The oxidized low density lipoprotein concentration is highest in patients with MS + CHD, and increased in patients with MS, which were significantly correlated with insulin resistance. This may contribute to the development to coronary heart disease from metabolic syndrome.
