CAJ | 학술논문

目的评定胶原聚合物为主体的ICL在动物体内的生物相容性。方法分别应用胶原材料进行以下生物学测试：(1)细胞毒性试验（细胞增殖度法）；(2)致敏试验；(3)热原试验；(4)皮下植入试验。实验数据根据标准进行分析和评估。结果细胞毒性试验、过敏试验和皮下植入试验，胶原试品反应均为0～1级。热原试验中胶原试品个体升温均在0.6℃以下，升温总值在1.4℃以下。结论材料生物学测试结果显示胶原聚合物具有高度生物相容性，是设计制造ICL的理想材料。
목적 평정효원취합물위주체적ICL재동물체내적생물상용성。방법 분별응용효원재료진행이하생물학측시：(1)세포독성시험（세포증식도법）；(2)치민시험；(3)열원시험；(4)피하식입시험。실험수거근거표준진행분석화평고。결과 세포독성시험、과민시험화피하식입시험，효원시품반응균위0～1급。열원시험중효원시품개체승온균재0.6℃이하，승온총치재1.4℃이하。결론 재료생물학측시결과현시효원취합물구유고도생물상용성，시설계제조ICL적이상재료。
Objective To evaluate compatibility of ICL made of collagen inanimal bodies.Methods Collagen was used to perform the following biological tests:(1)cytotoxicity test; (2)anaphylaxis test; (3)pyrogenic reactions test; (4)subcutaneous implant test. The data were analyzed and evaluated by criterion.Results Reaction scales of collagen in cytotoxicity, anaphylaxis and subcutaneous implant tests were 0 to 1 level. In pyrogenic reactions, the value of each rabbit's increasing temperature in collagen group was below 0.6℃ and the total value was below 1.4℃.Conclusion Results of material biological evaluation tests demonstrate that this copolymer is of high biocompatibility and can become an ideal material for ICL.