食品与药品
食品與藥品
식품여약품
FOOD AND DRUG
2009年
3期
46-48
,共3页
杨桂兰%张天亮%郭学平%曲保恩%宋永民
楊桂蘭%張天亮%郭學平%麯保恩%宋永民
양계란%장천량%곽학평%곡보은%송영민
透明质酸钙%毒理学%毒性试验%小鼠%大鼠
透明質痠鈣%毒理學%毒性試驗%小鼠%大鼠
투명질산개%독이학%독성시험%소서%대서
calcium hyaluronate%toxicology%toxicity test%mices%rat
目的 研究透明质酸钙的毒理学特性.方法 分别进行小鼠急性毒性实验和大鼠30 d喂养实验.结果 样品对小鼠的急性毒性LD50大于5 g/kg;实验期内大鼠生长发育良好,血常规及血生化各项指标均在正常范围,病理组织学检查各脏器均未见有意义的病理改变.结论 根据人体最大可能摄入量(100 mg/d)和急性毒性分级标准,透明质酸钙为无毒物质,对人体无毒害及副作用.
目的 研究透明質痠鈣的毒理學特性.方法 分彆進行小鼠急性毒性實驗和大鼠30 d餵養實驗.結果 樣品對小鼠的急性毒性LD50大于5 g/kg;實驗期內大鼠生長髮育良好,血常規及血生化各項指標均在正常範圍,病理組織學檢查各髒器均未見有意義的病理改變.結論 根據人體最大可能攝入量(100 mg/d)和急性毒性分級標準,透明質痠鈣為無毒物質,對人體無毒害及副作用.
목적 연구투명질산개적독이학특성.방법 분별진행소서급성독성실험화대서30 d위양실험.결과 양품대소서적급성독성LD50대우5 g/kg;실험기내대서생장발육량호,혈상규급혈생화각항지표균재정상범위,병리조직학검사각장기균미견유의의적병리개변.결론 근거인체최대가능섭입량(100 mg/d)화급성독성분급표준,투명질산개위무독물질,대인체무독해급부작용.
Objective To study the toxicity of calcium hyaluronate. Methods The toxicological characteristic of calcium hyaluronate is studied by mice acute toxicity test and 30 days feeding test in rats. Results LD50 of the sample was more than 5 g/kg·bw. The rata had fine growth during the whole test period, the indexes of blood rou-tine and blood biochemistry were all within normal limits and histopathological examination of the organs did not find significant pathological changes. Conclusion According to human maximum possible intake amount(100 mg/person ·day)and grade standard of acute toxicity, the calcium hyaluronate is in the non-toxic range and has no toxicity and side effect to human.
