CAJ | 학술논문

分析了全β类4个典型的蛋白质超家族中模体的功能,发现免疫球蛋白超家族和纤维结合蛋白类型Ⅲ超家族中的模体有相似的结构,但是它们行使不同的功能.血小板-白细胞C激酶底物的同源物结构域超家族和核酸结合超家族中的模体类型较多,虽然这些模体只是部分结构相似,然而它们却在各自的超家族中分别执行着相同的功能.文章进一步运用统计学方法研究了蛋白质超家族中保守模体的亲疏水特征、物理化学特征和结构特征.结果表明,模体差异有显著意义的残基存在于序列模体的保守位点上,相同的序列模体具有相似的二级结构.这些特征将对进一步识别超家族提供帮助.
분석료전β류4개전형적단백질초가족중모체적공능,발현면역구단백초가족화섬유결합단백류형Ⅲ초가족중적모체유상사적결구,단시타문행사불동적공능.혈소판-백세포C격매저물적동원물결구역초가족화핵산결합초가족중적모체류형교다,수연저사모체지시부분결구상사,연이타문각재각자적초가족중분별집행착상동적공능.문장진일보운용통계학방법연구료단백질초가족중보수모체적친소수특정、물이화학특정화결구특정.결과표명,모체차이유현저의의적잔기존재우서렬모체적보수위점상,상동적서렬모체구유상사적이급결구.저사특정장대진일보식별초가족제공방조.
By discussing the functional motifs of four protein superfamilies in all β class proteins, the results indicate that the similar structural motifs in Immunoglobulin and Fibronectin type Ⅲ superfamily have different functions.There are many types of sequence motifs in PH domain-like superfamily and Nucleic acid-binding proteins superfamily,but these little similar structural motifs have the same function in their respective superfamily.A statistical method is used to analyse the hydropathy,physicochemical and structural properties of motifs.The results show that the amino acid residues with significant difference are present in the conservative sites of sequence motifs and the same sequence motifs have the similar secondary structure of proteins.These correlated regularities will have some helps for the further identifying of different protein superfamilies and the related researches.