CAJ | 학술논문

目的:了解胰腺癌患者乙型肝炎病毒表面抗原(HBsAg)的发生情况,初步论证胰腺癌与乙型肝炎病毒(HBV)感染是否存在相关性,为胰腺癌早期诊断提供证据.方法:采用回顾性研究,分析本院2003年1月～2009年3月胰腺癌、肺癌和糖尿病患者HBsAg阳性率,并与全国普通人群对比.总体与样本率的比较采用Z检验;样本间率的比较采用χ~2检验.P＜0.05有统计学意义.结果:3701例患者符合纳入标准,其中胰腺癌组230例,HBsAg阳性率为16.1%;肺癌组1188例,HBsAg阳性率10.7%;糖尿病组2283例,HBsAg阳性率为11.6%.肺癌组患者与全国普通人群HBsAg阳性率差异无统计学意义(Z=1.104,P=0.163).糖尿病组患者与普通人群HBsAg阳性率差异有统计学意义(Z=2.98,P=0.002).胰腺癌患者HBsAg阳性率高于肺癌患者,OR=1.60,95% CI:1.077～2.382,χ~2=5.487,P=0.019.胰腺癌患者HBsAg阳性率高于糖尿病患者,OR=1.46,95% CI:1.004～2.123,χ~2=3.965,P=0.046.结论:胰腺癌可能有较高HBsAg阳性率,推测HBV感染与胰腺癌的发生可能存在一定的相关性.
목적:료해이선암환자을형간염병독표면항원(HBsAg)적발생정황,초보론증이선암여을형간염병독(HBV)감염시부존재상관성,위이선암조기진단제공증거.방법:채용회고성연구,분석본원2003년1월～2009년3월이선암、폐암화당뇨병환자HBsAg양성솔,병여전국보통인군대비.총체여양본솔적비교채용Z검험;양본간솔적비교채용χ~2검험.P＜0.05유통계학의의.결과:3701례환자부합납입표준,기중이선암조230례,HBsAg양성솔위16.1%;폐암조1188례,HBsAg양성솔10.7%;당뇨병조2283례,HBsAg양성솔위11.6%.폐암조환자여전국보통인군HBsAg양성솔차이무통계학의의(Z=1.104,P=0.163).당뇨병조환자여보통인군HBsAg양성솔차이유통계학의의(Z=2.98,P=0.002).이선암환자HBsAg양성솔고우폐암환자,OR=1.60,95% CI:1.077～2.382,χ~2=5.487,P=0.019.이선암환자HBsAg양성솔고우당뇨병환자,OR=1.46,95% CI:1.004～2.123,χ~2=3.965,P=0.046.결론:이선암가능유교고HBsAg양성솔,추측HBV감염여이선암적발생가능존재일정적상관성.
Objective: To analyze the association between hepatitis B virus (HBV) infection and pancreatic cancer. Methods: Retrospective analysis was performed to explore the positive rate of serum hepatitis B virus surface antigen (HBsAg) in patients with pancreatic cancer, lung cancer, diabetes mellitus and general population. Z test was used to compare the rate of HBV infection between the samples and general population. The rates among the samples were compared by Chi-square test. Results: A total of 3,701 registered patients seen in our hospital between January 1st 2003 and March 31st 2009 were collected. There were 230 pancreatic cancer patients with a positive rate of serum HBsAg of 16.1%, 1,188 lung cancer patients with a positive rate of serum HBsAg of 10.7%, and 2,283 patients with diabetes mellitus with a positive rate of serum HBsAg of 11.6%. There was no statistical significance in Z-test results between lung cancer patients and general population (Z=1.104, P=0.163), but the Z-test results between patients with diabetes mellitus and general population showed a statistical significance (Z=2.98, P=0.002). The positive rate of HBsAg was higher in pancreatic cancer patients than that in lung cancer patients (OR=1.60, 95% Cl: 1.077-2.382, r=5.487, P=0.019). Similar results were found between pancreatic cancer patients and diabetic patients (OR=1.46, 95% CI: 1.004-2.123, r=3.965, P=0.046). Conclusion: The positive rate of HBsAg is high in pancreatic cancer patients. There might be an association between HBV infection and pancreatic cancer.