中国医师杂志
中國醫師雜誌
중국의사잡지
JOURNAL OF CHINESE PHYSICIAN
2011年
11期
1476-1480
,共5页
杨腾舜%肖扬%姚岚%李兴%钟慧%唐炜立%刘石平%周鹏程%徐爱民%周智广
楊騰舜%肖颺%姚嵐%李興%鐘慧%唐煒立%劉石平%週鵬程%徐愛民%週智廣
양등순%초양%요람%리흥%종혜%당위립%류석평%주붕정%서애민%주지엄
肥胖症/代谢%糖尿病,2型/代谢%脂细胞/代谢%脂肪酸结合蛋白质类/代谢
肥胖癥/代謝%糖尿病,2型/代謝%脂細胞/代謝%脂肪痠結閤蛋白質類/代謝
비반증/대사%당뇨병,2형/대사%지세포/대사%지방산결합단백질류/대사
Obesity/ME%Diabetes mellitus,type 2/ME%Adipocytes/ME%Fatty acid-binding proteins/ME
目的 探讨血浆脂肪细胞脂肪酸结合蛋白(A-FABP)水平与肥胖类型,糖、脂代谢及胰岛素敏感性的关系.方法 采用双抗体夹心ELISA法检测正常糖调节正常体重者(NW-NGR)44例,正常糖调节超重/肥胖者(OB-NGR)36例,新诊断2型糖尿病(T2DM)及其亚组2型糖尿病正常体重组( NW-T2DM )89例和2型糖尿病伴超重/肥胖组(OB-T2DM)44例空腹状态下血浆A-FABP,同时测定血脂谱、空腹胰岛素及测量体重指数( BMI)、腰围(WC)、腰臀比(WHR)和脂肪含量(Fat％)；采用HOMAIR评价胰岛素敏感性.结果 校正年龄、性别后,OB-NGR组,NW-T2DM组及OB-T2DM组血浆AFABP高于NW-NGR组[11.32(6.54-15.43)μg/L、14.60( 10.35 -20.10) μg/L、18.25(12.85 -26.65)μg/L vs 9.32(3.72 - 14.00)μg/L,P均＜0.05].OB-NGR组与NW-T2DM组间血浆A-FABP差异无统计学意义[11.32(6.54-15.43)vs 14.60(10.35-20.10)μg/L,P＞0.05],但OB-NGR组与NW-T2DM组均低于OB-T2DM组[11.32(6.54 - 15.43)μg/L、14.60( 10.35 -20.10 )μg/L vs 18.25( 12.85 -26.65)μg/L,P ＜0.01].校正年龄、性别及BMI后,血浆A-FABP与WC、WHR、FPG、TG、FINS、HOMA-IR均呈正相关(r =0.416、0.341、0.344、0.196、0.306、0.312,P＜0.01).多元逐步回归分析示,HOMA-IR、性别、WC和年龄是血浆A-FABP主要的影响因素(P均＜0.05).结论 血浆A-FABP与腹型肥胖和胰岛素抵抗密切相关,可作为反映肥胖,特别是腹型肥胖的代谢标志物.
目的 探討血漿脂肪細胞脂肪痠結閤蛋白(A-FABP)水平與肥胖類型,糖、脂代謝及胰島素敏感性的關繫.方法 採用雙抗體夾心ELISA法檢測正常糖調節正常體重者(NW-NGR)44例,正常糖調節超重/肥胖者(OB-NGR)36例,新診斷2型糖尿病(T2DM)及其亞組2型糖尿病正常體重組( NW-T2DM )89例和2型糖尿病伴超重/肥胖組(OB-T2DM)44例空腹狀態下血漿A-FABP,同時測定血脂譜、空腹胰島素及測量體重指數( BMI)、腰圍(WC)、腰臀比(WHR)和脂肪含量(Fat％)；採用HOMAIR評價胰島素敏感性.結果 校正年齡、性彆後,OB-NGR組,NW-T2DM組及OB-T2DM組血漿AFABP高于NW-NGR組[11.32(6.54-15.43)μg/L、14.60( 10.35 -20.10) μg/L、18.25(12.85 -26.65)μg/L vs 9.32(3.72 - 14.00)μg/L,P均＜0.05].OB-NGR組與NW-T2DM組間血漿A-FABP差異無統計學意義[11.32(6.54-15.43)vs 14.60(10.35-20.10)μg/L,P＞0.05],但OB-NGR組與NW-T2DM組均低于OB-T2DM組[11.32(6.54 - 15.43)μg/L、14.60( 10.35 -20.10 )μg/L vs 18.25( 12.85 -26.65)μg/L,P ＜0.01].校正年齡、性彆及BMI後,血漿A-FABP與WC、WHR、FPG、TG、FINS、HOMA-IR均呈正相關(r =0.416、0.341、0.344、0.196、0.306、0.312,P＜0.01).多元逐步迴歸分析示,HOMA-IR、性彆、WC和年齡是血漿A-FABP主要的影響因素(P均＜0.05).結論 血漿A-FABP與腹型肥胖和胰島素牴抗密切相關,可作為反映肥胖,特彆是腹型肥胖的代謝標誌物.
목적 탐토혈장지방세포지방산결합단백(A-FABP)수평여비반류형,당、지대사급이도소민감성적관계.방법 채용쌍항체협심ELISA법검측정상당조절정상체중자(NW-NGR)44례,정상당조절초중/비반자(OB-NGR)36례,신진단2형당뇨병(T2DM)급기아조2형당뇨병정상체중조( NW-T2DM )89례화2형당뇨병반초중/비반조(OB-T2DM)44례공복상태하혈장A-FABP,동시측정혈지보、공복이도소급측량체중지수( BMI)、요위(WC)、요둔비(WHR)화지방함량(Fat％)；채용HOMAIR평개이도소민감성.결과 교정년령、성별후,OB-NGR조,NW-T2DM조급OB-T2DM조혈장AFABP고우NW-NGR조[11.32(6.54-15.43)μg/L、14.60( 10.35 -20.10) μg/L、18.25(12.85 -26.65)μg/L vs 9.32(3.72 - 14.00)μg/L,P균＜0.05].OB-NGR조여NW-T2DM조간혈장A-FABP차이무통계학의의[11.32(6.54-15.43)vs 14.60(10.35-20.10)μg/L,P＞0.05],단OB-NGR조여NW-T2DM조균저우OB-T2DM조[11.32(6.54 - 15.43)μg/L、14.60( 10.35 -20.10 )μg/L vs 18.25( 12.85 -26.65)μg/L,P ＜0.01].교정년령、성별급BMI후,혈장A-FABP여WC、WHR、FPG、TG、FINS、HOMA-IR균정정상관(r =0.416、0.341、0.344、0.196、0.306、0.312,P＜0.01).다원축보회귀분석시,HOMA-IR、성별、WC화년령시혈장A-FABP주요적영향인소(P균＜0.05).결론 혈장A-FABP여복형비반화이도소저항밀절상관,가작위반영비반,특별시복형비반적대사표지물.
Objective To explore the relationship between plasma A-FABP and obesity type and degree,glucose and lipid metabolism parameters and insulin sensitivity.Methods Plasma adipocyte fatty acid binding protein (A-FABP) was detected by double antibody sandwich ELISA in fasting status in subjects with normal glucose regulation and normal weight (NW-NGR,n =44),overweight or obese subjects with normal glucose regulation (OB-NGR,n =36),newly-diagnosed type 2 diabetes mellitus (T2DM) and its subgroups of T2DM with normal weight ( NW-T2DM,n =89 ) and T2D)M with overweight or obesity (OB-T2DM,n =44).And glucose,lipids,insulin levels as well as anthropometrical parameters such as body mass index ( BMI ),fat content ( Fat％ ),waist circumference (WC) and waist hip ratio (WHR) were measured.Meanwhile insulin sensitivity was assessed by HOMA-IR.Results After age and sex adjustment,plasma A-FABP levels in OB-NGR,NW-T2DM,and OB-T2DM were significantly higher than that of NW-NGR [11.32(6.54 - 15.43)μg/L,14.60(10.35 -20.10) μg/L,18.25(12.85 -26.65) μg/L vs 9.32(3.72 - 14.00) μg/L,all P ＜0.05].There was no difference in plasma A-FABP levels between OB-NGR and NW-T2DM [ 11.32 (6.54 - 15.43 ) vs 14.60 ( 10.35 -20.10) μg/L,P ＞ 0.05 ],but the plasma A-FABP levels in OB-NGR and NW-T2DM were significantly lower than that of OB-T2DM [ 11.32(6.54 - 15.43) μg/L,14.60( 10.35 -20.10) μg/L vs 18.25( 12.85 -26.65 ) μg/L,P ＜0.01 ].In a multiple stepwise regression analysis,HOMA-IR,sex,WC and age were the most significant independent determinants for plasma A-FABP concentration (all P ＜ 0.05 ).Conclusions Plasma A-FABP is strongly associated with the abdominal obesity and insulin resistance,measurement of plasma A-FABP concentrations might be useful for diagnosis of abdominal obesity and type 2 diabetics.
