CAJ | 학술논문

目的研究飞行员血液同型半胱氨酸(homocysteine,Hcy)水平变化,预测飞行员心血管事件的发生. 方法将163例飞行员和60例男性健康地面工作人员(对照组)按年龄分别设21～30岁、31～40岁和41～50岁组;同时按飞行时间将飞行员分别设≤1000 h、1001～2000 h、2001～3000 h和3001～4000 h组;采用全自动生化分析仪测定Hcy浓度. 结果飞行员组血液Hcy浓度为(9.86±4.45)μmol/L,对照组为(7.10±1.77)μmol/L.两组比较显示飞行员组血液Hcy明显高于对照组(t=4.67,P＜0.01);在不同年龄组血液Hcy测定中,对照组21～30岁组与41～50岁组差异显著(P＜0.05),飞行员不同年龄组之间差异均显著(P＜0.05或P＜0.01);在不同飞行时间血液Hcy测定中,1001～2000 h组、2001～3000 h组均与≤1000 h组差异显著(P＜0.01).同一年龄组中,飞行员血液Hcy浓度均高于对照组(t=3.893、6.221、3.193,P＜0.01). 结论测定血液Hcy可预测飞行员心血管事件发生的危险性,应针对飞行员血液Hcy升高采取强有力的干预措施,从而有效预防飞行员冠心病的发生.
목적 연구비행원혈액동형반광안산(homocysteine,Hcy)수평변화,예측비행원심혈관사건적발생. 방법 장163례비행원화60례남성건강지면공작인원(대조조)안년령분별설21～30세、31～40세화41～50세조;동시안비행시간장비행원분별설≤1000 h、1001～2000 h、2001～3000 h화3001～4000 h조;채용전자동생화분석의측정Hcy농도. 결과 비행원조혈액Hcy농도위(9.86±4.45)μmol/L,대조조위(7.10±1.77)μmol/L.량조비교현시비행원조혈액Hcy명현고우대조조(t=4.67,P＜0.01);재불동년령조혈액Hcy측정중,대조조21～30세조여41～50세조차이현저(P＜0.05),비행원불동년령조지간차이균현저(P＜0.05혹P＜0.01);재불동비행시간혈액Hcy측정중,1001～2000 h조、2001～3000 h조균여≤1000 h조차이현저(P＜0.01).동일년령조중,비행원혈액Hcy농도균고우대조조(t=3.893、6.221、3.193,P＜0.01). 결론 측정혈액Hcy가예측비행원심혈관사건발생적위험성,응침대비행원혈액Hcy승고채취강유력적간예조시,종이유효예방비행원관심병적발생.
Objective To study the change of homocysteine (Hcy) concerntration in pilot's blood and to predict the occurrence of cardiovascular events of pilots. Methods One hundred and sixty-three pilots and 60 male health ground service personnel were selected as pilot and control groups and respectively divided by age as 21-30, 31-40 and 41-50 yrs sub-groups. Pilots were also grouped into ≤ 1000 h, 1001-2000 h, 2001-3000 h and 3001-4000 h sub-groups by flying hours. The concentration of Hcy were detected by using automatic biochemical analyzer. Results The Hcy concentration in pilot group was (9.86±4.45) μmol/L comparing to (7.10±1.77) μmol/L in control group and the difference between groups was significant (t=4.67, P＜0.01). For the Hcy change by age, significant differences were between sub-group 21-30 yrs and 41-50 yrs in control group (P＜0.05), and between each two sub-groups in pilot group (P＜0. 05 or P＜0. 01). For the Hcy detection by flying hours, sub-group 1001-2000 h and 2001-3000 h respectively showed significant difference to ≤ 1000 h sub-group (P ＜ 0.01). Between the same age sub-groups, the Hcy concentration in pilots is higher than that in control groups (t=3. 893, 6. 221, 3. 193, P＜0.01).Conclusions Detecting the Hcy concentration in blood can be used to predict the risk of cardiovascular events of pilot. Taking powerful intervention measure to restrict the elevation of Hcy level can effectively prevent coronary heart disease of pilot.