CAJ | 학술논문

目的探讨正常肾上腺18F-脱氧葡萄糖(FDG) PET显像特征,为在18F-FDG PET或PET/CT显像中判断肾上腺是否有高代谢灶提供依据.方法选择行PET/CT体格检查的健康者100名.图像分析采用目测计分和测定标准摄取值(SUV)2种方法.目测计分法以肝为对照,肾上腺未显影为0分,放射性摄取低于肝放射性为1分,等于肝放射性为2分,高于肝放射性为3分;SUV由图像横断面测量,依据CT所显示的肾上腺和肝,手动勾画感兴趣区(ROI),获得左右两侧肾上腺、肝的SUV平均值(SUVmax)、SUV最大值(SUVmax),再计算肾上腺与肝SUV的比值.结果 (1)目测分析:左、右侧正常肾上腺放射性摄取分别有94%和91%等于或低于肝.(2)左、右侧正常肾上腺95%可信区间(CI)上限,SUVmax分别为1.39和1.65, SUVmax分别为1.98和2.19.(3)左、右侧正常肾上腺/肝比值的95%CI上限,SUVmax分别为0.65和0.75, SUVmax分别为0.76和0.83.(4)左、右侧肾上腺对18F-FDG摄取有一定差异,右侧肾上腺SUVmax和SUVmax均高于左侧.(5)除右侧SUVmax男性高于女性外,余各组性别差异无统计学意义.(6)正常肾上腺对18F-FDG摄取在＜60岁组和≥60岁组的差异无统计学意义.结论正常肾上腺18F-FDG生理性摄取程度的主要表现为低于肝.
목적 탐토정상신상선18F-탈양포도당(FDG) PET현상특정,위재18F-FDG PET혹PET/CT현상중판단신상선시부유고대사조제공의거.방법 선택행PET/CT체격검사적건강자100명.도상분석채용목측계분화측정표준섭취치(SUV)2충방법.목측계분법이간위대조,신상선미현영위0분,방사성섭취저우간방사성위1분,등우간방사성위2분,고우간방사성위3분;SUV유도상횡단면측량,의거CT소현시적신상선화간,수동구화감흥취구(ROI),획득좌우량측신상선、간적SUV평균치(SUVmax)、SUV최대치(SUVmax),재계산신상선여간SUV적비치.결과 (1)목측분석:좌、우측정상신상선방사성섭취분별유94%화91%등우혹저우간.(2)좌、우측정상신상선95%가신구간(CI)상한,SUVmax분별위1.39화1.65, SUVmax분별위1.98화2.19.(3)좌、우측정상신상선/간비치적95%CI상한,SUVmax분별위0.65화0.75, SUVmax분별위0.76화0.83.(4)좌、우측신상선대18F-FDG섭취유일정차이,우측신상선SUVmax화SUVmax균고우좌측.(5)제우측SUVmax남성고우녀성외,여각조성별차이무통계학의의.(6)정상신상선대18F-FDG섭취재＜60세조화≥60세조적차이무통계학의의.결론 정상신상선18F-FDG생이성섭취정도적주요표현위저우간.
Objective The purpose of this study was to obtain the 18F-fluorodeoxyglucose (FDG) uptake characteristics in normal adrenal gland as the criteria to diagnose abnormal glucose metabolism in adrenal gland by 18F-FDG PET or PET/CT imaging. Methods One hundred healthy persons underwent 18F-FDG PET/CT imaging in this study. The images were reviewed by visual judgement and measured by standardized uptake value (SUV). With reference to normal liver, the uptake of adrenal gland was scored from 0 to 3, namely, 0=no uptake, 1=less than the uptake of normal liver, 2=equal to the uptake of normal liver. 3=more than the uptake of normal liver. SUV was measured on the trans-axial images. The regions of interest (ROIs) of adrenal glands and livers were manually drawn based on the CT images. Both average SUV (SUVmax) and maximum SUV (SUVmax) were calculated. Results (1) By visual judgment, 94% and 91% of left and right normal adrenal glands had uptake intensity less than that of livers. (2) The SUVmax of left and right adrenal glands were 1.39 and 1.65, and the SUVmax 1.98 and 2.19, respectively with the upper limit of 95% confidence interval (CI). (3) The ratios of left and right adrenal glands SUVmax to livers SUVmax were 0.65 and 0.75 and left and right adrenal glands SUVmax to livers SUVmax were 0.76 and 0.83 respectively with the upper limit of 95% CI. (4) The uptake of right adrenal gland was higher than that of the left. (5) There was no significant difference of the SUVs between men and women, except that right adrenal gland SUVmax of men was higher than that of women. (6) There was no significant difference in 18F-FDG uptake between persons younger and elder than 60 years old. Conclusion The physiological FDG uptake of the adrenal gland in normal healthy individuals is generally lower than that of liver.