CAJ | 학술논문

目的探讨影响骨恶性纤维组织细胞瘤生存率、局部复发和远处转移的危险因素.方法 1997年7月至2010年7月共有56例骨恶性纤维组织细胞瘤患者接受治疗.对年龄、性别、肿瘤部位、肿瘤大小等9项可能影响预后的因素进行回顾性单因素和多因素分析.结果 44例患者获得随访,平均随访时间33.3个月(2周～78个月).5年总体生存率为50.1%,局部复发率为40.9%,局部复发中位时间12个月(3～60个月),术后转移发生率27.5%(11/40),中位转移时间为6.5个月(2～23个月).单因素分析结果表明,性别、就诊情况(初治和复发)、肿瘤部位、外科边界以及肿瘤分期与生存率有相关性(P＜0.05),外科边界、肿瘤部位与局部复发有相关性(P＜0.05),侵犯重要血管神经(有或无)与远处转移有相关性(P＜0.05);多因素分析显示,外科边界、肿瘤分期是影响生存率的独立危险因素,外科边界是影响局部复发的独立危险因素.结论外科边界、肿瘤分期是影响生存率的独立危险因素,外科边界是影响局部复发的独立危险因素.
목적 탐토영향골악성섬유조직세포류생존솔、국부복발화원처전이적위험인소.방법 1997년7월지2010년7월공유56례골악성섬유조직세포류환자접수치료.대년령、성별、종류부위、종류대소등9항가능영향예후적인소진행회고성단인소화다인소분석.결과 44례환자획득수방,평균수방시간33.3개월(2주～78개월).5년총체생존솔위50.1%,국부복발솔위40.9%,국부복발중위시간12개월(3～60개월),술후전이발생솔27.5%(11/40),중위전이시간위6.5개월(2～23개월).단인소분석결과표명,성별、취진정황(초치화복발)、종류부위、외과변계이급종류분기여생존솔유상관성(P＜0.05),외과변계、종류부위여국부복발유상관성(P＜0.05),침범중요혈관신경(유혹무)여원처전이유상관성(P＜0.05);다인소분석현시,외과변계、종류분기시영향생존솔적독립위험인소,외과변계시영향국부복발적독립위험인소.결론 외과변계、종류분기시영향생존솔적독립위험인소,외과변계시영향국부복발적독립위험인소.
Objective To study the risk factors related to the survival rate, recurrence and metastasis of malignant fibrous histiocytoma of bone.Methods From July 1997 and July 2010, 56 patients with malignant fibrous histiocytoma of bone were treated.Univariate and multivariate analysis were performed to determine the probable risk factors including gender, age, tumor location, tumor size and so on.Results Forty-four cases were followed up ranged from 2 weeks to 78 months ( medium 33.3).The 5-year overall survival rate was 50.1%, local reccurence rate 40.9% with a median time of 12 months (3 to 60 months)and metastatic rate 27.5% (11/40)with a median time of 6.5 months (2 to 23 months).Univariate analysis indicated that gender, condition of presentation ( primary case or recurrence case), tumor location, surgical margin and surgical stage were significantly related to survival rate ( P ＜ 0.05 ), and tumor location and surgical margin were related to local recurrence rate (P ＜ 0.05 ), and important vessel or nerve invasion was related to metastatic rate(P ＜ 0.05 ).Multivariate analysis showed that surgical margin and surgical stage were independent risk factors for survival rate, of which surgical margin was the independent risk factor for recurrence rate.Conclusions Surgical margin and surgical stage are independent risk factors for survival rate, of which surgical margin is the independent risk factor for recurrence rate.