CAJ | 학술논문

近年来,随着核酸及核酸类似物、聚乙二醇干扰素α等抗病毒药物的问世,使得慢性乙型肝炎临床抗病毒治疗取得了明显发展,同时对乙型病毒肝炎的实验室检测也提出了新的要求,促进了实验室诊断技术的发展.本研究着重讨论临床抗病毒治疗中乙型肝炎病毒DNA定量检测的应用和重要性,指出HBV DNA的定量检测病毒学应答对于判定抗病毒疗效、调整临床抗病毒治疗方案、停药后随访及预测预后等有重要意义.
근년래,수착핵산급핵산유사물、취을이순간우소α등항병독약물적문세,사득만성을형간염림상항병독치료취득료명현발전,동시대을형병독간염적실험실검측야제출료신적요구,촉진료실험실진단기술적발전.본연구착중토론림상항병독치료중을형간염병독DNA정량검측적응용화중요성,지출HBV DNA적정량검측병독학응답대우판정항병독료효、조정림상항병독치료방안、정약후수방급예측예후등유중요의의.
In recent years,antiviral therapy for chronic hepatitis B infected patients has achieved great development along with the invention of nucleos (t) ide,nucleos (t) ide analogues,interferon α and pegylated interferon α.The development of antiviral medicine also proposes new demands for the clinical diagnosis and therefore promotes the development of laboratory diagnostic techniques in the detection of chronic hepatitis B.In this review,we focused on the clinical application in the quantitive detection of HBV DNA,and its significance on clinical evaluation,treatment options,follow-up and prognosis in antiviral therapy.