中国组织工程研究与临床康复
中國組織工程研究與臨床康複
중국조직공정연구여림상강복
JOURNAL OF CLINICAL REHABILITATIVE TISSUE ENGINEERING RESEARCH
2007年
34期
6905-6907
,共3页
杨波%刘坤%冯晓迎%时向民%马楚云%陈彬%徐勇%陈练
楊波%劉坤%馮曉迎%時嚮民%馬楚雲%陳彬%徐勇%陳練
양파%류곤%풍효영%시향민%마초운%진빈%서용%진련
急性高原病%肥胖%发病率
急性高原病%肥胖%髮病率
급성고원병%비반%발병솔
背景:急性高原病的发生及严重程度取决于进入高原的速度、高原的海拔、季节等多种因素,而关于肥胖与高原病关系尚需进一步研究.目的:分析肥胖与急进高原者产生高原反应的关系.设计:对比观察.单位:解放军总医院心内科;解放军西藏军区总医院心内科.对象:于2006-08在西藏军区总医院心内科完成.从修筑青藏铁路的男性工人及其管理者中筛选参试者82名,年龄28～45 岁.均为急进高原者此前均未上过高原;均来自河北省(海拔0 m);均对检测项目知情同意.方法:①所有参试者需在平原地区、进入高原后12和24 h完成高原反应自我评价表.表中项目包括:头痛、胃肠道反应、乏力、头晕、失眠或入睡困难.上述5项症状评分为0～3 分,0为无症状,1轻度,2中度,3重度;总分为15分;评分达到4分以上可定义为急性高原病.②测量身高、体质量,计算体质量指数;以体质量指数≥28 kg/m2为肥胖组[n=39,平均年龄(35±8) 岁],体质量指数18.5～23.9 kg/m2为体质量正常组[n=43,平均年龄(35±8) 岁].③在平原和进入高原后24 h分别抽动脉血测定氧饱和度、氧分压、二氧化碳分压.④计量资料差异比较采用t检验.主要观察指标:肥胖与非肥胖者体质量指数、肺活量、动脉血氧饱和度、氧分压、二氧化碳分压比较.结果:肥胖者39名和非肥胖者43名均进入结果分析.①高原反应自我评价表评分:在平原地区参试者均无症状(评分0).但进入高原后12和24 h,肥胖组高原反应自我评价表评分分别为(1.7±1.1),(4.9±1.8)分,高于体质量正常组[(1.1±0.8),(2.8±2.2)分,t=2.843 2,4.701 6,P＜0.01].②血气分析结果:在平原地区肥胖与非肥胖组氧饱和度、氧分压、二氧化碳分压差异不明显(P＞0.05).进入高原后24 h,肥胖组的动脉血氧饱和度和氧分压分别为(83.5±3.2)%,(11.73±0.25) kPa,低于体质量正常组[(88.2±4.1)%,(11.98±0.28)kPa,t=5.744 7,4.280 2,P＜0.01],二氧化碳分压为(5.56±0.49) kPa,高于体质量正常组[(5.21±0.39)kPa,t=3.558 5,P＜0.01].结论:肥胖较体质量正常男性对高原缺氧更敏感,是发生急性高原病的重要危险因素.
揹景:急性高原病的髮生及嚴重程度取決于進入高原的速度、高原的海拔、季節等多種因素,而關于肥胖與高原病關繫尚需進一步研究.目的:分析肥胖與急進高原者產生高原反應的關繫.設計:對比觀察.單位:解放軍總醫院心內科;解放軍西藏軍區總醫院心內科.對象:于2006-08在西藏軍區總醫院心內科完成.從脩築青藏鐵路的男性工人及其管理者中篩選參試者82名,年齡28～45 歲.均為急進高原者此前均未上過高原;均來自河北省(海拔0 m);均對檢測項目知情同意.方法:①所有參試者需在平原地區、進入高原後12和24 h完成高原反應自我評價錶.錶中項目包括:頭痛、胃腸道反應、乏力、頭暈、失眠或入睡睏難.上述5項癥狀評分為0～3 分,0為無癥狀,1輕度,2中度,3重度;總分為15分;評分達到4分以上可定義為急性高原病.②測量身高、體質量,計算體質量指數;以體質量指數≥28 kg/m2為肥胖組[n=39,平均年齡(35±8) 歲],體質量指數18.5～23.9 kg/m2為體質量正常組[n=43,平均年齡(35±8) 歲].③在平原和進入高原後24 h分彆抽動脈血測定氧飽和度、氧分壓、二氧化碳分壓.④計量資料差異比較採用t檢驗.主要觀察指標:肥胖與非肥胖者體質量指數、肺活量、動脈血氧飽和度、氧分壓、二氧化碳分壓比較.結果:肥胖者39名和非肥胖者43名均進入結果分析.①高原反應自我評價錶評分:在平原地區參試者均無癥狀(評分0).但進入高原後12和24 h,肥胖組高原反應自我評價錶評分分彆為(1.7±1.1),(4.9±1.8)分,高于體質量正常組[(1.1±0.8),(2.8±2.2)分,t=2.843 2,4.701 6,P＜0.01].②血氣分析結果:在平原地區肥胖與非肥胖組氧飽和度、氧分壓、二氧化碳分壓差異不明顯(P＞0.05).進入高原後24 h,肥胖組的動脈血氧飽和度和氧分壓分彆為(83.5±3.2)%,(11.73±0.25) kPa,低于體質量正常組[(88.2±4.1)%,(11.98±0.28)kPa,t=5.744 7,4.280 2,P＜0.01],二氧化碳分壓為(5.56±0.49) kPa,高于體質量正常組[(5.21±0.39)kPa,t=3.558 5,P＜0.01].結論:肥胖較體質量正常男性對高原缺氧更敏感,是髮生急性高原病的重要危險因素.
배경:급성고원병적발생급엄중정도취결우진입고원적속도、고원적해발、계절등다충인소,이관우비반여고원병관계상수진일보연구.목적:분석비반여급진고원자산생고원반응적관계.설계:대비관찰.단위:해방군총의원심내과;해방군서장군구총의원심내과.대상:우2006-08재서장군구총의원심내과완성.종수축청장철로적남성공인급기관리자중사선삼시자82명,년령28～45 세.균위급진고원자차전균미상과고원;균래자하북성(해발0 m);균대검측항목지정동의.방법:①소유삼시자수재평원지구、진입고원후12화24 h완성고원반응자아평개표.표중항목포괄:두통、위장도반응、핍력、두훈、실면혹입수곤난.상술5항증상평분위0～3 분,0위무증상,1경도,2중도,3중도;총분위15분;평분체도4분이상가정의위급성고원병.②측량신고、체질량,계산체질량지수;이체질량지수≥28 kg/m2위비반조[n=39,평균년령(35±8) 세],체질량지수18.5～23.9 kg/m2위체질량정상조[n=43,평균년령(35±8) 세].③재평원화진입고원후24 h분별추동맥혈측정양포화도、양분압、이양화탄분압.④계량자료차이비교채용t검험.주요관찰지표:비반여비비반자체질량지수、폐활량、동맥혈양포화도、양분압、이양화탄분압비교.결과:비반자39명화비비반자43명균진입결과분석.①고원반응자아평개표평분:재평원지구삼시자균무증상(평분0).단진입고원후12화24 h,비반조고원반응자아평개표평분분별위(1.7±1.1),(4.9±1.8)분,고우체질량정상조[(1.1±0.8),(2.8±2.2)분,t=2.843 2,4.701 6,P＜0.01].②혈기분석결과:재평원지구비반여비비반조양포화도、양분압、이양화탄분압차이불명현(P＞0.05).진입고원후24 h,비반조적동맥혈양포화도화양분압분별위(83.5±3.2)%,(11.73±0.25) kPa,저우체질량정상조[(88.2±4.1)%,(11.98±0.28)kPa,t=5.744 7,4.280 2,P＜0.01],이양화탄분압위(5.56±0.49) kPa,고우체질량정상조[(5.21±0.39)kPa,t=3.558 5,P＜0.01].결론:비반교체질량정상남성대고원결양경민감,시발생급성고원병적중요위험인소.
BACKGROUND: The occurrence and severity of acute high-altitude disease(AHAD) are determined by the speed entering the highland, the altitude of highland and seasons. The association between obesity and AHAD has not been fully investigated.OBJECTIVE: To investigate the association between obesity and acute high-altitude in people exposed rapidly to the highland.DESIGN: Comparative observation.SETTING: Department of Cardiology, General Hospital of Chinese PLA and Department of Cardiology, Tibetan General Hospital of Chinese PLA.PARTICIPANTS: The experiment was conducted at the Department of Cardiology, General Hospital of Tibetan Military Area Command of Chinese PLA in August 2006. Totally 82 Henan subjects aged 28-45 years were selected from the male workers constructing the Qinghai-Tibet Railway and their managers with acute high-altitude exposure. They had never been to the highland before, and all agreed to the detection.METHODS: ①Every subject completed the AHAD self-report questionnaire at sea level and 12 hours and 24 hours after ascending high-altitude. The items in the questionnaire included symptoms of headache, gastrointestinal symptoms,fatigue or weakness, dizziness, and insomnia. Each symptom was graded from 0-3 with 0 as no symptoms, 1 as mild symptoms, 2 as moderate symptoms, and 3 as severe symptoms and a total score of 15. A score of 4 or more could by identified as AHAD. ②The height and body mass were measured to calculate the body mass (BMI). Those with BMI≥28 kg/m2 served as the obesity group [n =39, mean age (35±8) years], and those with BMI of 18.5-23.9 kg/m2 as the normal body mass group [n =43, mean age (35±8) years]. ③Arterial blood was taken to evaluate arterial oxygen saturation (SO2), arterial oxygen pressure (PaO2) and arterial carbon dioxide pressure (PaCO2) at baseline and 24 hours after ascending high-altitude. ④The measurement data was compared by t test.MAIN OUTCOME MEASURES: BMI, vital capacity of lungs, SO2, PaO2 and PaCO2 levels of obese and normal people.RESULTS: Totally 39 obese people and 43 normal people were involved in the result analysis. ①AHAD score: No symptom was reported at sea level in all participants (scored 0), but the AHAD scores in the obesity group were significantly higher than those in normal group 12-hour and 24-hour after ascending high-altitude. ②Blood gas analysis:At sea level, there were no statistical differences in the levels of SO2, PaO2, and PaCO2 between two groups (P ＞ 0.05).But 24 hours after ascending high-altitude, SO2 and PaO2 of the obesity group were much lower than in the normal group (P＜ 0.01), and PaCO2 was significantly higher than in the normal group (P＜ 0.01).CONCLUSION: Obese men are more vulnerable to high-altitude hypoxia than people with normal body mass. Obesity is an important risk factor for the development of acute high-altitude disease.
